Navigation Links
Parallel brainstem circuit discovery suggests new path in Parkinson's research
Date:5/19/2010

action can be a very long time.

The researchers discovered the actual brain neurotransmitter that activates muscarine receptors -- another chemical, acetylcholine -- sends a signal to these newly discovered brainstem neurons, switching them on for the lengthy minute or so durations.

Alford said the finding opens up new insights into animal locomotion.

"It's a system for turning on your locomotor system and making you walk or run in a very coordinated, straight-line fashion sustaining locomotion for a considerable time," he said. "This simply was not known to exist before we discovered it."

The role of the neurotransmitter acetylcholine may ultimately suggest new Parkinson's disease treatments. While a key Parkinson's symptom is tremor, an advanced stage symptom is the inability to start a movement, such as walking. Symptoms associated with Parkinson's can be helped by reducing acetylcholine-mediated neurotransmission in the brain, but little work has focused on brainstem muscarine receptors in this disease.

"This may be a backdoor finding into a secondary effect of Parkinson's disease that's not well studied because most research emphasis has been on dopamine and the basal ganglia, a different neurotransmitter and region of the brain," Alford said.


'/>"/>

Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Quantum weirdness, parallel worlds, dinosaur poop, and the ultimate fate of the universe...
2. Small RNA plays parallel roles in bacterial metabolism
3. Microfluidic integrated circuit could help enable home diagnostic tests
4. Tissue engineering, imaging neuronal circuits featured in Cold Spring Harbor Protocols
5. Johns Hopkins scientists discover a controller of brain circuitry
6. NTU and EDB launch S$50 million ($36 million) integrated circuit design research center
7. Understanding a cells split personality aids synthetic circuits
8. Electrical circuit runs entirely off power in trees
9. Mouse brain rewires its neural circuits to recuperate from damaged neural function after stroke
10. CSHL study finds short- and long-term memories require same gene but in different circuits
11. Abnormal brain circuits may prevent movement disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... the right time might actually help boost a species, ... in understanding animal populations, pest control and managing fish ... journal Trends in Ecology and Evolution , a ... kind of positive population effect an overall species experiences ... the size and developmental stage of the creatures that ...
(Date:11/4/2014)... – (Nov. 4, 2014) – A majority of Madagascar,s ... that could have serious consequences for the rainforests they ... shows the positive impacts lemurs can have on rainforest ... their disappearance could have on the region,s rich biodiversity. ... have fruits eaten by lemurs. Lemurs in turn ...
(Date:11/3/2014)... birth weight and preterm birth are linked to increased ... published in the American College of Rheumatology (ACR) journal, ... birth weight and pre-term babies were not at greater ... , According to the ACR, 27 million Americans ... OA. Symptoms of OA range from mild to severe ...
Breaking Biology News(10 mins):When less is more: Death in moderation boosts population density in nature 2Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3Preterm, low birth-weight babies may need new hips in adulthood 2
... long been considered a major risk factor for cardiovascular ... risk, but the mechanisms of how arteries stave off ... the Perelman School of Medicine, University of Pennsylvania, Wistar ... that the protein apolipoprotein E (apoE) plays a major ...
... the Nowgen Schools Genomics Programme website launches with a range ... genetics in schools and colleges. , Developments in genetics research ... at a cost of $3 billion to sequencing a genome ... genetics in classroom education have remained relatively static. The pace ...
... Research led by Chu Chen, PhD, Associate Professor of Neuroscience ... enzyme called Monoacylglycerol lipase (MAGL) as a new therapeutic target ... online November 1, 2012 in the Online Now section of ... that inactivation of MAGL, best known for its role in ...
Cached Biology News:Softening arteries, protecting the heart 2Softening arteries, protecting the heart 3Bridging the gap between genomics and education 2LSUHSC research identifies new therapeutic target for Alzheimer's disease 2
(Date:11/21/2014)... The California Healthcare Institute ... representing leading California academic institutions, biotechnology, medical device, ... today released a report revealing that California ... The trend shows a 4 percent increase between ... Industry Report indicates that, while biopharmaceutical and ...
(Date:11/21/2014)... 2014 Deep Research Report on Global ... and in-depth research report on the Sodium ferrocyanide ... its definition, classification, application, and industry chain structure ... the international market analysis, including China’s domestic market ... Europe, Asia, China, Japan etc. regions) industry analysis ...
(Date:11/21/2014)... , Nov. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or ... month periods ended September 30, 2014.  Biorem,s complete 2014 third quarter ... ). Financial Summary:Three-months ended September 30, , ... share data) , 2014 , 2013 ... , 5,281 , 6,715 , ...
(Date:11/18/2014)... Athena Signature Series: Turning Cancer ‘Off’ – featuring Dr. ... in the Regulatory Biology Laboratory at the Salk Institute, studies ... an “off switch” for drug resistance in cancer. , Learn ... is making a global impact in the fight against cancer. ... Cheryl K. Goodman, CEO of Social Global Mobile LLC, for ...
Breaking Biology Technology:California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3
... , COLUMBIA, Md., Sept. 8 Martek Biosciences ... of judges on the United States Court of Appeals for the ... to a patent infringement lawsuit between Martek and Lonza, Ltd., Nutrinova ... The appeals involve Lonza,s U.S. sale and use of DHA ...
... $5 Million Loan Will Leverage $15 Million ... , HARRISBURG, Pa., Sept. 8 Early-stage life ... create quality jobs with the help of a state investment in ... "The life sciences are a growth sector for Pennsylvania," ...
... Inc. (TSX: ONC, NASDAQ: ONCY ), will present ... Renshaw 11th Annual Healthcare Conference on Thursday, September 10, ... at the New York Palace Hotel from September 9 to ... will be available at: http://www.wsw.com/webcast/rrshq15/oncy or on the ...
Cached Biology Technology:Federal Circuit Rules in Martek's Favor in Appeal of Patent Infringement Case 2Federal Circuit Rules in Martek's Favor in Appeal of Patent Infringement Case 3PA Helping Life Science Companies Secure Venture Capital Needed to Expand, Gov. Rendell Says 2Media Advisory - Oncolytics Biotech Inc. to Present at Rodman Renshaw 11th Annual Healthcare Conference 2
Rat monoclonal [HK5.3] to B7 RP1 (Biotin) ( Abpromise for all tested applications). entrezGeneID: 23308 SwissProtID: O75144...
Rabbit polyclonal to ZFP200 ( Abpromise for all tested applications). Antigen: Synthetic peptide: CGKSFNHKTNLNKHER (Human) Entrez Gene ID: 7752 Swiss Protein ID: P98182...
BACE (CT) rabbit polyclonal antibody...
Rabbit polyclonal to MA2 ( Abpromise for all tested applications). entrezGeneID: 10687 SwissProtID: Q9UL42...
Biology Products: