Navigation Links
Parallel brainstem circuit discovery suggests new path in Parkinson's research
Date:5/19/2010

Chicago and Montreal researchers studying the lowly lamprey eel have identified an overlooked nervous system pathway running parallel to known brainstem locomotor command circuitry in vertebrates such as birds, fishes and mammals.

The finding is reported in Nature Neuroscience, online May 16, and highlighted in the magazine's "news and views" section.

Simon Alford, University of Illinois at Chicago professor of biological sciences and the article's corresponding author, said the role of a neurotransmitter associated with this parallel pathway may also suggest new research directions for treating Parkinson's disease.

Alford, along with his former graduate student and lead author Roy Smetana, now a University of Pittsburgh resident in psychiatry, worked with Universit de Montral and Universit de Qubec Montral neurobiologist Rjean Dubuc and his post-doctoral researcher Laurent Juvin in trying to sort out how the neurotransmitter analog muscarine modifies sensory information going to the brain.

Their work determined that muscarine stimulated neural activity, leading to locomotion in the laboratory lampreys.

The group focused its attention on a collection of brainstem neurons that tell the spinal cord to generate motor output that enables walking and other locomotion.

"We started looking at this group of neurons, which in the lamprey are conveniently very large, so they're easy to plant electrodes and record from," said Alford. "We discovered the muscarinic excitation was not working on these cells, but on a previously unknown group of cells within the brainstem."

What's more, these newly discovered brainstem neurons showed what Alford called a "very odd response" to the muscarine.

"Instead of just turning on -- like a synapse turns on a neuron and makes it fire -- when you put muscarine on these cells, they turn on and stay on" for a minute or longer which he said for a neurological re
'/>"/>

Contact: Paul Francuch
francuch@uic.edu
312-996-3457
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Quantum weirdness, parallel worlds, dinosaur poop, and the ultimate fate of the universe...
2. Small RNA plays parallel roles in bacterial metabolism
3. Microfluidic integrated circuit could help enable home diagnostic tests
4. Tissue engineering, imaging neuronal circuits featured in Cold Spring Harbor Protocols
5. Johns Hopkins scientists discover a controller of brain circuitry
6. NTU and EDB launch S$50 million ($36 million) integrated circuit design research center
7. Understanding a cells split personality aids synthetic circuits
8. Electrical circuit runs entirely off power in trees
9. Mouse brain rewires its neural circuits to recuperate from damaged neural function after stroke
10. CSHL study finds short- and long-term memories require same gene but in different circuits
11. Abnormal brain circuits may prevent movement disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... NXTD and NXTDW) a biometric authentication company focused on ... Wocket™ smart wallet at CES 2015 in Las Vegas ... the "11 Hot Products at CES" in a review published in Wired.com, ... Newseveryday.com and "The top 10 gadgets from CES 2015" by Danny ...
(Date:1/22/2015)...   EyeLock, Inc. , a market leader of iris-based identity ... to the new role of Senior Vice President of ... of mobile platforms and wearable solutions for EyeLock,s technologies. Gerber ... the semiconductor industry to his role at EyeLock, with expertise ...
(Date:12/22/2014)... Holiday Season may be the brightest ever for the ... long anticipated floodgates for consumer biometrics may finally be ... tablets, and wearable mobile devices that incorporate biometrics will ... nearly 4.8 billion biometric devices by 2020.   ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2
... in biomechanics and physiology from six universities, led ... of Technologys Media Lab, refute scientific claims that ... South African bilateral amputee track athlete, provide him ... Their conclusions were based on data collected at ...
... has long been a concern for environmental scientists and ... excessive reactive nitrogen in the environment is little-known beyond ... the element cycles through the environment and negatively alters ... Two new papers by leading environmental scientists bring ...
... NY) Contrary to long-held assumptions, high-salt diets ... to investigators from the Albert Einstein College of ... after examining dietary intake among a nationally representative ... researchers actually observed a significantly increased risk of ...
Cached Biology News:Breaking news: Study revives Olympic prospects for amputee sprinter 2Breaking news: Study revives Olympic prospects for amputee sprinter 3Addressing the 'nitrogen cascade' 2Addressing the 'nitrogen cascade' 3New study casts further doubt on risk of death from higher salt intake 2
(Date:1/22/2015)... 22, 2015 Crystal Diagnostics (CDx) Xpress System, ... has received AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing ... collectively referred to as STEC or the “Big-6”) as well ... unit (cfu) per 325 g of raw ground beef and ...
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision ... tools to enable the broad use of genomic, imaging and ... the appointment of Michelle Munson , CEO of Aspera, ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 ...
(Date:12/24/2014)... Dec. 24, 2014  Vermillion, Inc. (Nasdaq:   VRML), ... announced today that the Company closed its previously ... Management, Jack W. Schuler , Birchview Fund ... $10.5 million, before offering expenses.  The proceeds will ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... the leading,management consulting firm specializing in the pharmaceutical ... practice,will be taking a leadership role at the ... by the Center for Business Intelligence,(CBI). The conference ... Crown Plaza,Valley Forge in King of Prussia, Pennsylvania. ...
... (Nasdaq:,CPHD) will present at the William Blair & ... at 10:40 a.m. ET at the New York ... Financial Officer and Dr.,David Persing, Cepheid,s Chief Medical ... The webcast, along with accompanying presentation slides, may ...
... The Netherlands and LONDON, September 26 ,Nobilon International ... business,unit of Akzo Nobel, and Protherics PLC, the ... today announced that Nobilon,has licensed Protherics, CoVaccine HT(TM) ... influenza vaccines in elderly people. More than ...
Cached Biology Technology:Campbell Alliance Managed Markets Practice to Take Leadership Role at CBI's Formulary and Reimbursement Conference 2Campbell Alliance Managed Markets Practice to Take Leadership Role at CBI's Formulary and Reimbursement Conference 3Cepheid to Present at William Blair Small-Cap Growth Stock Conference 2Protherics Licenses its CoVaccine HT Adjuvant to Nobilon for Influenza Vaccine Indications 2Protherics Licenses its CoVaccine HT Adjuvant to Nobilon for Influenza Vaccine Indications 3