Navigation Links
Paradigm shift in Alzheimers's research: new treatments
Date:10/15/2007

Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by extensive neuronal degeneration and the development of neuritic amyloid plaques and neurofibrillary tangles. Neuronal and synaptic losses in AD are correlated with dementia and occur in specific brain areas involved in memory processing.

Long-standing evidence shows that progressive cerebral deposition of A" plays a seminal role in the pathogenesis of AD. There is great interest, therefore, in understanding the proteolytic processing of APP, the precursor of A", and its proteases responsible for generating A". Ragged peptides with a major species beginning with phenylalanine at position 4 of Ab have been reported already in 1985 by Masters et al.1.

In 1992, Mori et al. first described the presence of A"N3(pE) using mass spectrometry of purified A" protein from AD brains, which explains the difficulties in sequencing the amino-terminus2. They reported that only 10-15% of the total A" isolated by this method begins at position 3 with A"N3(pE). Later it became clear that A"N3(pE) represents a dominant fraction of A" peptides in AD and Downs syndrome brain3-15.

N-terminal deletions in general enhance aggregation of "-amyloid peptides in vitro16. A"N3(pE) has a higher aggregation propensity17,18, and stability19, and shows an increased toxicity compared to full-length A"20. In AD only a small proportion of A" starts at position 1 with L-aspartate in plaques (~10%), and this fraction is higher in vascular amyloid (~65%). In plaques, ~50% of the amyloid starts at position 3 in the form of A"N3(pE), whereas in the vascular amyloid, this form accounts for only 11%5.

A comparison between amyloid peptides of cognitively normal elderly people and AD patients showed that soluble amyloid aggregates are different between these groups. In AD the major A" species started with N3(pE) and ended at the C-terminus at position 4211.

Neuropatholo
'/>"/>

Contact: Thomas A. Bayer
tbayer@gwdg.de
European College of Neuropsychopharmacology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Navigating the brain for sense of direction as paradigm for higher cognitive functions
2. Protein splicing upsets the DNA colinearity paradigm
3. Shift of weather patterns necessitates rethinking of reforestation methods
4. After a time-shift, mixed signals from the circadian clock
5. Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
6. Radio-tracking associated with dramatic shift in water vole sex ratio
7. Neandertal femur suggests competition with hyenas and a shift in landscape use
8. Shifty-eyed Monkeys Offer Window Into Brains Social Reflexes
9. Molecular research suggest shift needed in how some drugs are created
10. Great (taste) expectations: Study shows brain anticipates taste, shifts gears
11. Evolutionary shifts in olfactory sensitivities in fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... areas of sea ice melt in the summer and when ... thinner and more reduced. As the Arctic summers are getting ... reduced sea ice in the Arctic will remove less CO2 ... are representative, then sea ice plays a greater role than ... global CO2 budgets", says Dorte Haubjerg Sgaard, PhD Fellow, Nordic ...
(Date:9/21/2014)... of cowpea (black-eyed peas) is a fascinating example of ... fascinating is the story of the scientist behind the ... Legume of the 21st Century to serve as an ... book was recently published by the Crop Science Society ... Agriculture (IITA). , Singh has devoted his life,s work ...
(Date:9/21/2014)... and barnacles secrete very sticky proteins that help them ... by these natural adhesives, a team of MIT engineers ... repair ships or help heal wounds and surgical incisions. ... researchers engineered bacteria to produce a hybrid material that ... bacterial protein found in biofilms slimy layers formed ...
Breaking Biology News(10 mins):Arctic sea ice helps remove CO2 from the atmosphere 2Engineered proteins stick like glue -- even in water 2Engineered proteins stick like glue -- even in water 3
... R.I. [Brown University] The cactus, stalwart of the desert, ... plant communities found the world over. In a paper ... the National Academy of Sciences , Brown University biologists and ... between 5 and 10 million years ago and coincided with ...
... NEW ... in Brazil,s Pantanal and Cerrado regions can benefit both cattle and wildlife, ... , The technique, which has been adapted for a variety of ... periods of time before moving onto other pastures. The result is a ...
... Osama bin Laden,s leadership, al Qa,ida has been one ... responsible for more than 10,000 deaths and injuries in ... http://www.start.umd.edu/start/publications/br/BackgroundReport_AQAttacks.pdf > by the National Consortium for the Study ... of Maryland (START) . "Al-Qa,ida, the terrorist ...
Cached Biology News:Succulent plants waited for cool, dry Earth to make their mark 2Succulent plants waited for cool, dry Earth to make their mark 3Grazing as a conservation tool 2Bin Laden's attacks among the most lethal: UMD study 2
(Date:9/22/2014)... Texas (PRWEB) September 22, 2014 This ... state of the M-Phenylenediamine (mPDA) industry in Global ... the industry, including definitions, applications and industry chain structure. ... provided with a focus on history, developments, trends and ... international and Chinese situation is also offered. , The ...
(Date:9/22/2014)... Research and Markets has announced ... Cellulose Industry Report 2014" report to their offering. ... Industry Report 2014 is a professional and in-depth study ... industry with a focus on the Chinese situation. ... industry including definitions, classifications, applications and industry chain structure. ...
(Date:9/22/2014)... 22, 2014  WIRB-Copernicus Group (WCG), the world,s ... for clinical research, announced today that its Western ... reaccredited by the Association for the Accreditation of ... improve safeguards for clinical research participants. ... , Ph.D., commented, "It is of utmost importance ...
(Date:9/21/2014)... in Switzerland have succeeded in observing the "forbidden" ... first time. These extremely weak spectra offer perspectives ... may also contribute to the development of molecular ... in the scientific journal Nature Physics . ... matter and light, is probably the most important ...
Breaking Biology Technology:m-Phenylenediamine Industry: mPDA Global & China Trend Analysis Now Available at ReportsnReports.com 2m-Phenylenediamine Industry: mPDA Global & China Trend Analysis Now Available at ReportsnReports.com 3Global and Chinese Microcrystalline Cellulose Industry Report 2014 2Western IRB (WIRB) Awarded AAHRPP Reaccreditation 2Uncovering the forbidden side of molecules 2
... 2011 Bacterin International Holdings, Inc. (NYSE Amex: ... revolutionary bone graft material and antimicrobial coatings for medical applications, ... Healthcare Conference. The conference will be held at the Four ... Bacterin,s chairman and CEO, Guy Cook, and CFO, John ...
... NEWTOWN SQUARE, Pa., Aug. 24, 2011 Kibow Biotech, ... worldwide licensing and marketing agreement with the current licensing ... a patented, 100% natural, probiotic dietary supplement indicated for ... moderate to severe renal failure. Developed by Kibow, Azodyl™ ...
... generated stem cells from one of the most rapidly progressing ... into the condition as it will enable scientists to model ... certain nerve cells die. Scientists, funded with a 300,000 ... a patient diagnosed with one of the most progressive types ...
Cached Biology Technology:Bacterin International to Present at Stifel Nicolaus 2011 Healthcare Conference on September 8, 2011 2Kibow Biotech, Inc. Secures $2.4 Million Towards Its Human Clinical Trials by Continued Veterinary Licensing Agreement 2Stem cell study offers hope for Parkinson's patients 2
... The flexible and easy to ... to control all members of ... It features a clear and ... assay setup, user-friendly and highly ...
... Recombinant Enterokinase (rEK) is a highly ... bovine enterokinase, a serine protease which recognizes ... enzyme (AspAspAspAspLys?) and has similar enzymatic activity ... coli and purified to yield the highest ...
Roll of Mesh 5m x 25cm...
Angiotensin Converting Enzyme [Porcine Kidney, ACE, Peptidyl-dipeptidase A]...
Biology Products: