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Paracetamol, one of most used analgesics, could slow down bone growth

In Medicine, paracetamol is used to soothe every kind of pain, from simple molar pain to pain produced by bone fractures. This medicine is one of the most used nowadays. However, research carried out at the Departamento de Enfermeria of the University of Granada showed that taking paracetamol slows down bone growth, as has been proved by in vitro studies.

Author of this work is Olga Garca Mart nez, and her analysis takes as a starting point several clinical processes in which accelerating bone growth is required. Certain anti-inflammatories such as paracetamol warns the researcher should be cautiously taken, specially in situations which require a rapid bone tissue regeneration, such as after placement of a prosthesis or dental implant. Other anti-inflammatories which have no effects on bone growth should be used instead. Results of her work can not be confirmed in humans but in vitro research shows without a question that paracetamol slows down bone regeneration.

Plasma rich in growth factors

Research of Garca Mart nez was carried out on osteoblasts (cells involved in bone regenerating processes), obtained via bone samples. Apart from the effects of paracetamol on bone cells in culture, the author also studied the effect of plasma rich in growth factors (obtained from patients' own blood and after a spinning process). Application of this plasma gel on bones accelerates their growth, without affecting other cell parameters such as the cell cycle or the antigenic profile.

It is therefore an easy technique which involves few risks for the patient, who will recover from bone defects more quickly.

Even though her work has been carried out on osteoblasts, Garca Mart nez states that it could also be used on other kinds of cells such as fibroblasts, and can therefore be used not only on bones but also on soft tissue, which would help to heal wounds and ulcers.


Contact: Dr. Olga Garca Mart nez
Universidad de Granada

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