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Paper offers insights into network that plays crucial role in cell function and disease
Date:2/5/2014

w stathmin works. The experiments (primarily designed and performed by Kamlesh Gupta) present experimental evidence that stathmin can act directly on microtubules and it does so by binding and destabilizing segments of the assembling microtubule before they can be incorporated into the final microtubule structure. Accompanying computer simulations show that this type of molecular activity could produce the experimentally observed effects of microtubule dynamics.

"This work is significant because this disassembly process is essential for basic cell survival and because stathmin, also called oncoprotein 18, is dramatically over produced in a number of cancers," Alber said. "Understanding how the protein works is an important step towards figuring out how to inhibit it, which may provide a route for new anti-cancer drugs."


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Contact: Mark Alber
malber@nd.edu
574-631-8371
University of Notre Dame
Source:Eurekalert

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