Navigation Links
Pandemic flu can infect cells deep in the lungs, says new research
Date:9/10/2009

current pandemic have experienced relatively mild symptoms. However, some people have had more severe lung infections, which can be worse than those caused by seasonal flu. Our new research shows how the virus does this - by attaching to receptors mostly found on cells deep in the lungs. This is something seasonal flu cannot do."

The researchers found that pandemic H1N1 influenza bound more weakly to the receptors in the lungs than to those in the upper respiratory tract. This is why most people infected with the virus have experienced mild symptoms. However, the researchers are concerned that the virus could mutate to bind more strongly to these receptors.

"If the flu virus mutates in the future, it may attach to the receptors deep inside the lungs more strongly, and this could mean that more people would experience serious symptoms. We think scientists should be on the lookout for these kinds of changes in the virus so we can try to find ways of minimising the impact of such changes," added Professor Feizi.

The researchers compared the way seasonal and pandemic H1N1 flu viruses infect cells by identifying which receptors each virus binds to. To do this, the researchers used a glass surface with 86 different receptors attached to it, called a carbohydrate microarray. When viruses were added to the glass surface, they stuck to their specific receptors and the corresponding areas on the plate 'lit up'. This meant the researchers could see which receptors the different viruses attached to.

Pandemic H1H1 influenza could bind strongly to receptors called α2-6, which are found in the nose, throat and upper airway, and it could also attach more weakly to α2-3 receptors, which are found on cells deeper inside the lungs. However, seasonal H1N1 influenza could only attach to α2-6.

"Receptor binding determines how well a virus spreads between cells and causes an infection," said Professor Feizi. "Our new study adds t
'/>"/>

Contact: Lucy Goodchild
lucy.goodchild@imperial.ac.uk
44-207-594-6702
Imperial College London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. K-State researcher, collaborators study virulence of pandemic H1N1 virus
2. 1 in 6 health workers wont report in flu pandemic -- study by Ben-Gurion U. researchers
3. Swine flu genes dissimilar to past pandemics
4. New World post-pandemic reforestation helped start Little Ice Age, say Stanford scientists
5. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
6. Rethinking who should be considered essential during a pandemic flu outbreak
7. Survivors of 1918 flu pandemic protected with a lifetime immunity to virus
8. VaxInnate to discuss seasonal and pandemic flu vaccines during BIO 2008 this week
9. NASA technology helps predict and prevent future pandemic outbreaks
10. Mounting a multi-layered attack on fungal infections
11. Single host gene may hold key to treating both ebola and anthrax infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jan. 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), ... crowdfunding campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz ... production capacity to meet customer demand. ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... technology and tech stocks, releases video from the CES 2015 ... security consultant Apollo Robbins . Apollo shows ... Wocket™ biometric smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
(Date:1/22/2015)... Infinisource has launched its new NXG series of time ... sets a higher standard for collecting attendance and labor data ... plug-and-play installation, touch screen interface and seamless connection to cloud-based ... collection solution for the small to mid-size employer. ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Infinisource's NXG series sets new time clock standard 2
... (EGFR), a so-called kinase protein, is often abnormally active ... the activated EGFR kinase have shown to be effective ... study in PLoS Medicine, researchers have catalogued and characterized ... glioblastoma, a deadly type of brain tumor. The researchers ...
... the New York-based Wildlife Conservation Society (WCS) working in ... Positioning System) collars on eight saiga antelope in an ... ?and endangered ?large mammals. , Standing just under two ... the most striking feature of the saiga is its ...
... of one-letter characters in the human genome sequence lies ... this level of architecture, scientists have developed powerful new ... (CNVs)--defined as large deletions and duplications of DNA segments. ... Research --were used to create the first comprehensive map ...
Cached Biology News:Asia's odd-ball antelope gets collared 2New technology used to construct the first map of structural variation in the human genome 2
(Date:1/22/2015)... (PRWEB) January 21, 2015 Cambridge Semantics, the ... technology, today announced that 2014 was a record-breaking year across ... capabilities of the Anzo Smart Data Platform and our Smart ... utilize insights from diverse data which led to record growth ...
(Date:1/22/2015)... Boston, MA (PRWEB) January 22, 2015 ... systems, is pleased to announce an exciting product from a ... of motion analysis solutions over the past 15 years, with ... industries. Most recently, their 3D IMU system (inertial measurement unit), ...
(Date:1/22/2015)... NEW BRUNSWICK , Nueva Jersey , 22 ... Award for Biomedical Research abre hoy su llamada ... las personas cuya investigación científica ha hecho, o tiene ... de la salud humana. Las nominaciones se aceptarán hasta ...
(Date:12/25/2014)... 25, 2014 The report “Service Quality ... Type & Provider Type - Global Advancements, Worldwide Forecasts ... an in-depth analysis and forecasting of revenues. , ... 221 pages and in-depth TOC on “Service Quality Management ...
Breaking Biology Technology:Cambridge Semantics Announces Record Results for 2014 23D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... Biopharma Inc., a Canadian,biopharmaceutical company, announced that ... first contracts with customers in biopharmaceutical development ... 30 minutes from Toronto,s Pearson,International Airport, Therapure ... development and manufacture of complex biological,products. Leveraging ...
... Sept. 3 Wyeth (NYSE: WYE ),today ... to Vice,President, Corporate Communications. Reporting to Timothy P. ... be responsible for all,internal and external communications for ... consumer health care and animal health,-- around the ...
... held September 24 to 26 in Kansas City. , ... ... (USP) Convention’s 2008 Annual Scientific Meeting (ASM) will be held in ... opportunity to interact with the USP experts responsible for establishing internationally ...
Cached Biology Technology:Therapure Biopharma Inc. opens for business with first client contracts 2Wyeth Names Daniel J. McIntyre Vice President, Corporate Communications 2USP's 2008 Annual Scientific Meeting to Convene Scientific Experts from Around the World 2USP's 2008 Annual Scientific Meeting to Convene Scientific Experts from Around the World 3
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
...
Normal Hamster Serum...
Biology Products: