Navigation Links
Pandemic flu can infect cells deep in the lungs, says new research
Date:9/10/2009

Pandemic swine flu can infect cells deeper in the lungs than seasonal flu can, according to a new study published today in Nature Biotechnology. The researchers, from Imperial College London, say this may explain why people infected with the pandemic strain of swine-origin H1N1 influenza are more likely to suffer more severe symptoms than those infected with the seasonal strain of H1N1. They also suggest that scientists should monitor the current pandemic H1N1 influenza virus for changes in the way it infects cells that could make infections more serious.

Influenza viruses infect cells by attaching to bead-like molecules on the outside of the cell, called receptors. Different viruses attach to different receptors, and if a virus cannot find its specific receptors, it cannot get into the cell. Once inside the cell, the virus uses the cell's machinery to make thousands more viruses, which then burst out of the cell and infect neighbouring ones, establishing an infection.

Seasonal influenza viruses attach to receptors found on cells in the nose, throat and upper airway, enabling them to infect a person's respiratory tract. Today's research, which was funded by the Wellcome Trust, the Medical Research Council and the Engineering and Physical Sciences Research Council, shows that pandemic H1N1 swine flu can also attach to a receptor found on cells deep inside the lungs, which can result in a more severe lung infection.

The pandemic influenza virus's ability to stick to the additional receptors may explain why the virus replicates and spreads between cells more quickly: if a flu virus can bind to more than one type of receptor, it can attach itself to a larger area of the respiratory tract, infecting more cells and causing a more serious infection.

Professor Ten Feizi, a corresponding author of today's paper from the Division of Medicine at Imperial College London, said: "Most people infected with swine-origin flu in the
'/>"/>

Contact: Lucy Goodchild
lucy.goodchild@imperial.ac.uk
44-207-594-6702
Imperial College London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. K-State researcher, collaborators study virulence of pandemic H1N1 virus
2. 1 in 6 health workers wont report in flu pandemic -- study by Ben-Gurion U. researchers
3. Swine flu genes dissimilar to past pandemics
4. New World post-pandemic reforestation helped start Little Ice Age, say Stanford scientists
5. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
6. Rethinking who should be considered essential during a pandemic flu outbreak
7. Survivors of 1918 flu pandemic protected with a lifetime immunity to virus
8. VaxInnate to discuss seasonal and pandemic flu vaccines during BIO 2008 this week
9. NASA technology helps predict and prevent future pandemic outbreaks
10. Mounting a multi-layered attack on fungal infections
11. Single host gene may hold key to treating both ebola and anthrax infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Wake Forest Baptist ... education building for its School of Medicine. Funding for ... larger capital campaign that will be publicly launched next ... be located in the former 60 series R.J. Reynolds ... Innovation Quarter. Construction will begin immediately with plans to ...
(Date:12/5/2014)... 2014  Tute Genomics, a leader in cloud-based solutions ... A1 funding led by UK-based Eurovestech. Peak Ventures and ... investment round. "We are at a pivotal ... sequencing and seeks new approaches for the diagnosis, treatment ... MD MBA, and CEO of Tute Genomics. "One of ...
(Date:11/21/2014)... Nov. 19, 2014  Earlier this year Donald ... College, and one of the most prolific inventors in ... are transmitted from Smartphones to third party agencies. Spector ... has one of the earliest known patents in this ... in the military, child care, elder care and hospital ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... very good at what they do. But they don,t ... work in oily or dangerous environments, or in any kind ... of the fastest and most maneuverable creatures on the planet, ... to their streamlined bodies and a finely tuned muscular/sensory/control system. ...
... Rochelle, NY, September 19, 2012 Many biotech observers ... be based on the field of personalized medicine, ... ( GEN ) ( http://genengnews.com ). Although drug ... of biosamples, demand is exceeding supply, fueling the ...
... researchers at Michigan State University has documented the step-by-step process ... in the current issue of Nature , are revealed ... coli bacteria figured out how to supplement a traditional ... "It,s pretty nifty to see a new biological function evolve," ...
Cached Biology News:Robotic tuna is built by Homeland Security 2Evolution is as complicated as 1-2-3 2
(Date:12/24/2014)... , Dec. 23, 2014 China Biologic ... "Company"), a leading fully integrated plasma-based biopharmaceutical company ... that its majority-owned subsidiary, Shandong Taibang Biological Products ... certification from the China Food and Drug Administration ... facility. As previously disclosed in the Company,s public ...
(Date:12/24/2014)... and NEW YORK , Dec. 23, ... open-label pilot study of mazindol in children with attention ... Therapy in December 2014 . The ... children with attention deficit/hyperactivity disorder" ( Konofal et al, ... Dec 1;8:2321-2332. eCollection 2014 ) shows that mazindol ...
(Date:12/22/2014)... 2014 GenomeDx Biosciences today announced that a ... a genomic test for prostate cancer, was able to ... by radical prostatectomy without adjuvant therapy. Although rapid metastasis ... using tumor genomics to identify these men who have ... important advance. The study has been published online ...
(Date:12/19/2014)... Hershey, PA (PRWEB) December 19, 2014 ... a leading developer and manufacturer of needle-free injection ... an agreement with Immunomic Therapeutics, Inc. (“ITI”) for ... injection device with its LAMP™ vaccine platform. ... for an exclusive Worldwide license to the Biojector®-2000 ...
Breaking Biology Technology:China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3
... Ondine Biopharma,Corporation (TSX: OBP; AIM: OBP), a ... that a poster entitled,"Photodisinfection in the Treatment ... representatives at the American Academy of,Periodontology,s (AAP) ... being,held at the Washington State Convention and ...
... XI,AN, China, Sept. 5 /Xinhua-PRNewswire-FirstCall/ -- Huifeng Bio-,Pharmaceutical ... leading developer and producer of plant extracts and ... food production in,Xi,an, China, is pleased to announce ... arrangement with Xi,an Qinba Xintong Medical Ltd. ("Qinba").,Under ...
... MEDQ ) today announced that its board of directors has ... join the board, effective,September 4, 2008. Prior to the election ... of the board from seven to 10 members., According ... to have this opportunity to further enhance the quality and,experience ...
Cached Biology Technology:Ondine Announces Presentation of Positive Clinical Trial Results at the American Academy of Periodontology's 94th Annual Meeting 2Huifeng Bio-Pharmaceutical (HFGB) Enters into Letter of Intent with Xi'an Qinba Xintong Medical Ltd. 2MedQuist Announces Additions to Board of Directors 2MedQuist Announces Additions to Board of Directors 3