This year's Pathway to Leadership Grant recipients are:
For the initial, mentored phase of Bailey's project, she will work in the laboratories of Steven D. Leach, M.D., and Anirban Maitra, M.D. Maitra received the 2004 AACR-Pancreatic Cancer Action Network Career Development Award, and both organizations are proud to see him now in a position to mentor another young scientist.
Bailey's project, Stop the Start: Novel Insights into PanIN Initiation and Progression, pursues sophisticated studies of the earliest events in pancreatic cancer initiation and progression.
More than 90 percent of pancreatic cancer patients have mutations in a protein called KRAS. Because the exact cell of origin for pancreatic cancer has not been defined, Bailey will develop a "next generation" mouse model of early pancreatic cancer formation, engineering different cell types in the pancreas to express mutated KRAS. Utilizing a fluorescent label attached only to cells with activated KRAS, Bailey will be able to visualize and isolate pancreas cells at various time points following KRAS activation. This way, she can study the effects of mutant KRAS activation in cells before the formation of the earliest known stage of pancreatic cancer development, the pancreatic intraepith
|Contact: Michele Sharp|
American Association for Cancer Research