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Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants awarded to early-career investigators
Date:3/25/2011

rous and transparent process. Importantly, in addition to receiving research funds, grant recipients are provided with career development opportunities. These include mentorships and connections with senior scientists in the field; invitations to present at scientific sessions, lead conference workshops and participate in training and educational webinars; site visits to mentor laboratories to learn new techniques and skills; involvement with pancreatic cancer survivors and their caregivers; and resources to keep them apprised of emerging developments in the field.

This year's Pathway to Leadership Grant recipients are:

  • Jennifer M. Bailey, Ph.D., postdoctoral research fellow, Johns Hopkins University School of Medicine

For the initial, mentored phase of Bailey's project, she will work in the laboratories of Steven D. Leach, M.D., and Anirban Maitra, M.D. Maitra received the 2004 AACR-Pancreatic Cancer Action Network Career Development Award, and both organizations are proud to see him now in a position to mentor another young scientist.

Bailey's project, Stop the Start: Novel Insights into PanIN Initiation and Progression, pursues sophisticated studies of the earliest events in pancreatic cancer initiation and progression.

More than 90 percent of pancreatic cancer patients have mutations in a protein called KRAS. Because the exact cell of origin for pancreatic cancer has not been defined, Bailey will develop a "next generation" mouse model of early pancreatic cancer formation, engineering different cell types in the pancreas to express mutated KRAS. Utilizing a fluorescent label attached only to cells with activated KRAS, Bailey will be able to visualize and isolate pancreas cells at various time points following KRAS activation. This way, she can study the effects of mutant KRAS activation in cells before the formation of the earliest known stage of pancreatic cancer development, the pancreatic intraepith
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Contact: Michele Sharp
Michele.Sharp@aacr.org
267-646-0622
American Association for Cancer Research
Source:Eurekalert

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