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Pairing up: How chromosomes find each other
Date:11/1/2011

play a role later in meiosis, when chromosomes separate from their partners.

"There's reason to believe that some parts of that process will be at least explorable and potentially applicable to humans," Hawley said.

The work also is notable as an example of discovery-based science, Hawley said. "We didn't actually set out to study the initiation of meiosis; we were simply interested in characterizing the basic biology of early meiosis."

But postdoctoral researcher and first author Satomi Takeo, Ph.D., noticed that centromere clustering and synaptonemal complex initiation occurred in concert, and her continued observations revealed the role of centromeres in initiating synapsis.

"I was staring with tired eyes at the cells that I was analyzing," Takeo recalls. "Somehow I started looking at the spots I had previously ignoredprobably because I thought they were just background noiseuntil I saw the connection between centromere clustering and synapsis initiation. After going through many images, I wrote an email to Scott, saying, 'This is really important, isn't it??' With that finding, everything else started to make sense."


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Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

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