Navigation Links
PTSD research: Distinct gene activity patterns from childhood abuse
Date:5/1/2013

in the patterns of which genes were turned on and off in blood cells from patients. They also looked at patterns of methylation, a DNA modification on top of the four letters of the genetic code that causes genes to be 'silenced' or made inactive.

Study participants were divided into three groups: people who experienced trauma without developing PTSD, people with PTSD who were exposed to child abuse, and people with PTSD who were not exposed to child abuse.

The researchers were surprised to find that although hundreds of genes had significant changes in activity in the PTSD with and without child abuse groups, there was very little overlap in patterns between these groups. The two groups shared similar symptoms of PTSD, which include intrusive thoughts such as nightmares and flashbacks, avoidance of trauma reminders, and symptoms of hyperarousal and hypervigilance.

The PTSD with child abuse group displayed more changes in genes linked with development of the nervous system and regulation of the immune system, while the PTSD minus child abuse group displayed more changes in genes linked with apoptosis (cell death) and growth rate regulation. In addition, changes in methylation were more frequent in the PTSD with child abuse group. The authors believe that these biological pathways may lead to different mechanisms of PTSD symptom formation within the brain.

The Max Planck/Emory scientists were probing gene activity in blood cells, rather than brain tissue. Similar results have been obtained by researchers studying the influence of child abuse on the brains of people who had committed suicide.

"Traumatic events that happen in childhood are embedded in the cells for a long time," Binder says. "Not only the disease itself, but the individual's life experience is important in the biology of PTSD, and this should be reflected in the way we treat these disorders."


'/>"/>

Contact: Kathi Baker
kobaker@emory.edu
404-727-9371
Emory Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Dartmouth research: The clocks are ticking and the climate is changing
2. Influenza research: Can dynamic mapping reveal clues about seasonality?
3. New research: Soluble corn fiber plays important role in gut health and calcium absorption
4. Research: Many programs to help diabetics manage their health do work
5. Research: Modern Portfolio Theory optimizes conservation practices
6. UC research: Saving habitat key to songbirds survival
7. MIT research: Study finds room to store CO2 underground
8. UC research: Tracking Lake Erie water snake in fight against invasive fish
9. MIT research: The power of being heard
10. Genetics defines a distinct liver disease
11. Distinct developmental patterns identified in children with autism during their first 3 years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 16, 2015  A man-made form of insulin delivered by ... capabilities in adults with mild cognitive impairment and Alzheimer,s ... researchers at Wake Forest Baptist Medical Center. ... mild cognitive impairment (MCI) or mild to moderate Alzheimer,s ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... of the "Global Wearable Technologies Market and ... Overview, Trends and Forecast 2014-2020" report to ... are smart devices that can be worn on ...
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ) ... Global Watermarking and Fingerprinting Markets" report to ... This insight provides an overview ... markets. Watermarking aims to control and monitor piracy ...
Breaking Biology News(10 mins):Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2The Global Watermarking and Fingerprinting Markets 2
... by researchers at UC Davis shows how our very short-term ... information, operates. The system retains a limited number of high-resolution ... of fuzzier impressions. Humans rarely move their eyes smoothly. ... system briefly shuts off to cut down visual "noise," said ...
... of Mount Sinai Medical Center, New York was honored ... Fellowship in Biochemical Genetics at the ACMG 2008 Annual ... of the Genzyme/ACMGF Award is to support a national ... clinicians in the field of clinical biochemical genetics and ...
... to permanent paralysis and loss of sensation below the site ... The nerve fibers or axons have the capacity to grow ... develops around the injury. Northwestern University researchers have ... of scar tissue at the injury site and enables the ...
Cached Biology News:Working memory has limited 'slots' 2Promising new nanotechnology for spinal cord injury 2
(Date:1/23/2015)... Portal Solutions , a technology consulting firm that ... 365 and SharePoint platforms , today announces its inclusion in ... of the region’s fastest-growing mid-sized companies based on a combined ... be recognized a second year in a row by SmartCEO ...
(Date:1/22/2015)... 22, 2015  Transwestern | RBJ today announces the firm brokered ... for Shire a leading biopharmaceutical company, at Two Ledgemont Center ... Robert Richards , president, and Brian Cohen , ... entire five-floor building at 95 Hayden Ave. Photo ...
(Date:1/22/2015)... (PRWEB) January 21, 2015 Cambridge Semantics, the ... technology, today announced that 2014 was a record-breaking year across ... capabilities of the Anzo Smart Data Platform and our Smart ... utilize insights from diverse data which led to record growth ...
(Date:1/22/2015)... Rootstown, OH (PRWEB) January 22, 2015 Crystal ... announced today that it has received AOAC-PTM Certifications for the ... O111, O121, and O145; collectively referred to as STEC or ... at 1 colony forming unit (cfu) per 325 g of ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... 31, 2011 International Isotopes Inc. (OTC Bulletin ... announces a conference call to discuss progress during ... planned uranium de-conversion and fluorine extraction processing facility. ... Uranium Project Update Conference CallWhen: Monday, February 7, ...
... 31, 2011 Frontier Global Sciences, a leading ... metals, announced today it has expanded its capabilities ... spectrometry (ICP-MS) instrument. The purchase of a Perkin ... offer additional ICP-MS services including standard quadropole, true ...
... Mass., Jan. 28, 2011 Virtify, Inc., a leading ... sciences industry, today announced the appointment of Craig Smith ...  A twenty-year veteran of the enterprise software industry, Smith ... exceeding revenue targets, establishing new markets and building outstanding ...
Cached Biology Technology:International Isotopes Inc. Announces a Shareholder Conference Call for February 7, 2011 2International Isotopes Inc. Announces a Shareholder Conference Call for February 7, 2011 3Content Management and Life Sciences Software Veteran Joins Virtify as Vice President of Worldwide Sales 2Content Management and Life Sciences Software Veteran Joins Virtify as Vice President of Worldwide Sales 3
... technology, the Lone Wolf valve has the ... proportional valve available on the market. This ... high-speed performance, and ensures maximum accuracy., ... system control and patient comfort. , Maintains ...
... is the smallest electronic pressure controller available ... Parker configured this unit specifically for the ... Used in carrier gas flow control, microfluidic ... and hydro-dynamic focusing, the OEM-EPC offers external ...
... (Low Flow) offers the same benefits as the ... where control is critical or flow is required ... the flow of gas in proportion to the ... or pulse width modulation; closed loop feedback delivers ...
...
Biology Products: