Navigation Links
PNAS: Precise molecular surgery in the plant genome

This press release is available in German.

The new method is based on the natural repair mechanism of plants. So-called homologous recombination repairs the genome when the genome strands in the cell break. "Using an appropriate enzyme, i.e. molecular scissors, we first make a cut at the right point in the genome and then supply the necessary patch to repair this cut," says Friedrich Fauser from Karlsruhe Institute of Technology, who is the first author of the PNAS publication. "A part of this patch is the new gene piece we want to install. The rest is done by the repair service of the cell."

Due to this trick, the method that is referred to as "in planta gene targeting" (IPGT) is highly reliable and the new genetic information is incorporated in the genome precisely at the point desired. In principle, IPGT may be applied to every plant. "This is a big advantage compared to conventional methods that work for certain plants only and produce a lot of rejects," explains Professor Holger Puchta, who holds the Chair for Molecular Biology and Biochemistry of Plants at Karlsruhe Institute of Technology. "Thanks to appropriate molecular scissors and patches and the natural repair mechanism of the cell, IPGT is about 100 times more efficient than techniques used so far."

With their experiments on the model plant of thale cress (Arabidopsis thaliana), the researchers of KIT, in cooperation with the company SunGene GmbH, a subsidiary of BASF Plant Science having its office at Gatersleben, have now succeeded in furnishing evidence of the fact that IPGT works in plants. "The next step towards broader application in biotechnolgoy will be the transfer of the principle to other plants and the development of appropriate scissors and patches," says Puchta. In this way, the favorable properties of wild species can be transferred rapidly to crop plants. The long-term objective is the optimum use of natural resources for the production of food and vegetable raw materials.

Contact: Monika Landgraf
Helmholtz Association of German Research Centres

Related biology news :

1. Frost & Sullivan Recognizes Precise Biometrics as a Key Player in the Non-AFIS Fingerprint Market
2. Nano-tetherball biosensor precisely detects glucose
3. Mobile Communication Market Opens up for Biometrics - Precise Biometrics Awarded 1st Prize at GSMA World Mobile Congress
4. New theory gives more precise estimates of large-scale biodiversity
5. US Government Places 6,1 Million USD Orders Related to Precise Match-on-Card(TM) for Cyber Security Programs
6. Tool allows precise targeting of radiotherapy for cancer radiation therapy
7. Precise trace gas analysis, without the noise
8. Technique enables precise control of protein activity in living cells
9. NC State develops more precise genetic off switches
10. Researchers discover precisely how thalidomide causes birth defects
11. UBC megapixel DNA replication technology promises faster, more precise diagnostics
Post Your Comments:
Related Image:
PNAS: Precise molecular surgery in the plant genome
(Date:4/28/2016)... April 28, 2016 First quarter 2016:   ... 966% compared with the first quarter of 2015 The ... 589.1 M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) ... guidance is unchanged, SEK 7,000-8,500 M. The operating margin ...
(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf ... join the faculty of the University of North Carolina Kenan-Flagler Business School ... and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, ...
(Date:6/24/2016)... June 24, 2016  Regular discussions on a range of ... between the two entities said Poloz. Speaking at ... Ottawa , he pointed to the country,s inflation target, ... government. "In certain ... institutions have common economic goals, why not sit down and ...
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
Breaking Biology Technology: