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PLoS Genetics 2009 maize genome collection
Date:11/19/2009

f most of the DNA in a chromosome. Although the work focuses on maize, the results are pertinent across all organisms, including humans."

Maize Centromere Structure and Evolution: Sequence Analysis of Centromeres 2 and 5 Reveals Dynamic Loci Shaped Primarily by Retrotransposons
Wolfgruber TK, Sharma A, Schneider KL, Albert PS, Koo DH, et al.

Because centromeres - the point or region on a chromosome to which the spindle attaches during mitosis and meiosis - consist of highly repetitive DNA sequences, these regions are exceedingly difficult to map and thus usually the last genomic regions to be assembled in genome projects. Using a comprehensive and general approach for mapping centromeres, Wolfgruber and colleagues precisely mapped all ten maize centromeres, constructed detailed maps of two centromeres, and determined the latter's present-day, as well as historic, boundaries. These findings that centromeres are dynamic loci that can shift over time have provided valuable insights into corn centromere evolution that may prove helpful in the design of artificial chromosomes of corn and other plants.


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Contact: Tamsin Milewicz
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Source:Eurekalert

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