Navigation Links
PGD can permit the birth of healthy children to women carrying mitochondrial DNA disease
Date:5/30/2011

earchers studied data on 159 different disease-causing mtDNA mutations derived from 327 unrelated patients or families. They combined data on muscle mutant levels which correlate best with prenatal tissues - of affected individuals and relatives on their mothers' side who were not affected., and were able to predict that a 95% or greater chance of being unaffected was linked to a mtDNA mutant level of 18% or less.

Mitochondria have their own DNA, which is strictly inherited from the mother. Normal and mutant DNA co-exist in most disease-causing mtDNA mutations, and there is a threshold of mutant mtDNA which must be exceeded before clinical symptoms occur. The mtDNA mutation level inherited by the offspring of a female mutation carrier can vary greatly, and even in twin births, it is possible for one baby to receive considerably more of the mutant mtDNA molecules than the other.

"Being able to find the minimal level of mutant mtDNA below which the chances of passing on a disorder is low was therefore very important", said Dr. Hellebrekers. Currently, there are no effective treatments for mtDNA disorders. Although we cannot guarantee that a mutant mtDNA level of 18% or lower will result in the birth of an unaffected child, we think that the chances of having a healthy child are high enough to make using PGD in this instance morally acceptable.

"Our research enables us to give genetic counselling to women at risk with respect to their reproductive choices and to provide them, for the first time, with the opportunity to give birth to a healthy baby. The prevalence of mtDNA disorders is 1 in 5,000, which means that the families of about 146,000 patients in Europe can now have the option of having a healthy child. This is a choice that they do not currently have", she concluded.


'/>"/>

Contact: Mary Rice
mary.rice@riceconseil.eu
European Society of Human Genetics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Plasticity of hormonal response permits rapid gene expression reprogramming
2. Eminent group of scientists call for moratorium on issuance of mountaintop mining permits
3. New open-source software permits faster desktop computer simulations of molecular motion
4. Parental exposure to BPA during pregnancy associated with decreased birth weight in offspring
5. Researchers discover precisely how thalidomide causes birth defects
6. Major breakthrough in preventing premature birth announced by NIH/WSU
7. Fewer multiple births in states with insurance coverage for infertility
8. Study provides explanation for connection between low birth weight and obesity later in life
9. Compound useful for studying birth defects may also have anti-tumor properties
10. Men attend childbirth classes for partners sake
11. New research helps explain how progesterone prevents preterm birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... 4, 2014 Increased emphasis on product ... new testing and inspection technologies. The convergence of ... a range of innovative test solutions. This trend ... Y, which is generally more inclined towards communication, ... development strategies of test equipment vendors will cater ...
(Date:12/3/2014)... Dec. 2, 2014 As part of our ... Technologies is pleased to announce the release of a ... to collect the workforce data that they need. ... been left by existing readers. Many such devices have ... and modern technology. Older models force users to navigate ...
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... attaining a reliable water supply for California and ... realized until better planning can identify how trade-offs ... water is limited, says a new report from ... been ineffective in meeting these goals because management ...
... Research led by Lauren Cole, a public health graduate ... Health and Director of the Epidemiology Program at LSU ... of head and neck cancer has risen at sites ... greatest increase among middle-aged white men. At the same ...
... An international team of researchers led by the University ... discovery of a breast cancer risk gene and could assist ... Melissa Southey of the Genetic Epidemiology Laboratory, Department of Pathology ... it was a significant discovery and the first breast cancer ...
Cached Biology News:Increasing water scarcity in California's Bay-Delta will necessitate trade-offs; 'hard decisions' needed to balance various environmental risks 2Increasing water scarcity in California's Bay-Delta will necessitate trade-offs; 'hard decisions' needed to balance various environmental risks 3Increasing water scarcity in California's Bay-Delta will necessitate trade-offs; 'hard decisions' needed to balance various environmental risks 4LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men 2Breast cancer risk gene discovery fast tracked by new technology 2
(Date:12/19/2014)... Decision Resources Group finds that the Latin ... percent compound annual growth rate through 2023. This is ... the increasing adoption of dental implants. Growing aesthetic consciousness ... spur demand for dental biomaterials because they can improve ... Other key findings from Decision Resources Group,s ...
(Date:12/19/2014)... 18, 2014 Today, TiFiber, ... pilot production facility and future company headquarters in ... innovative new materials that safely and effectively control ... because of its historic, strong support for manufacturing, ... attract leading edge, technology-based companies such as TiFiber. ...
(Date:12/19/2014)... 2014 Reports from CDC ... suffer from one or more chronic health conditions - ... can address some of these diseases, but may not ... sufferers face. While implanted nerve stimulation devices today offer ... nerve, which can induce side effects. , To ...
(Date:12/19/2014)... December 19, 2014 The empty ... the rising ageing population and technological innovations in ... nutraceutical industries are catalysing the growth of the ... http://www.marketsandmarkets.com/Market-Reports/empty-capsules-market-218018190.html , Scope of Report , ... well as new entrants/smaller firms to gauge the ...
Breaking Biology Technology:Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4
... P&G,s Commitment to Sustainable Innovation., Accelerates LS9,s Entry into ... ... South San Francisco, CA (PRWEB) -- LS9, Inc., the ... Procter and Gamble (NYSE: PG), one of world,s largest consumer ...
... goBalto.com , ... San Francisco, CA ... partnering site for the pharmaceutical development and drug manufacturing industry, ... of India-based Investigator Sites and hospitals available on goBalto.com. , ...
... Reprints NRx for the Force.com AppExchange saves time for ... process from within Salesforce CRMSANTA MONICA, Calif., May 19 ... announced the availability of Reprints NRx for ... the Force.com platform, Reprints NRx for the AppExchange is ...
Cached Biology Technology:LS9 and Procter & Gamble Launch Sustainable Chemicals Partnership 2goBalto Partners with Maya Clinicals to Expand Its List of Investigator Sites 2goBalto Partners with Maya Clinicals to Expand Its List of Investigator Sites 3Reprints Desk Medical Reprint Service Now Available to Life Science Professionals on the Force.com AppExchange 2Reprints Desk Medical Reprint Service Now Available to Life Science Professionals on the Force.com AppExchange 3
Ms anti-Cyclophilin D...
... to qualitatively detect EGFR ... paraffin-embedded (FFPE) tissue sections, ... cell preparations, using Chromogenic ... Fluorescent In Situ Hybridization ...
Mouse GM CSF Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient...
Biology Products: