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PD map: Putting together the pieces of the Parkinson's puzzle
Date:10/23/2013

Parkinson's disease continues to puzzle physicians and biologists alike - even though it is well-established that symptoms like muscle tremors, rigidity, and, during the final stages, immobility can all be traced back to the death of a certain type of brain cell called a dopaminergic neuron. The underlying cause of this cellular death is a complex web of interrelated genetic molecular processes as well as external factors, most of the details of which are well-known. But how the various factors correlate and influence each other continues to elude the scientific community. Now for the first time ever, researchers at the Luxembourg Centre for Systems Biomedicine (LCSB) at the University of Luxembourg have published an interactive picture containing the current knowledge about the underlying genetic and molecular causes of Parkinson's disease. This "Parkinson's disease map," or "PD Map" for short has been published in the scientific journal Molecular Neurobiology. It will facilitate the systematic study of PD through a newly gained clarity of the existing knowledge about the disease (DOI 10.1007/s12035-013-8489-4).

"Indeed, biomedical research continuously gives us many new insights about Parkinson's." says Dr. Marek Ostaszewski, coordinator of the LCSB PD Map project. "Each year, thousands of new scientific publications appear on the subject - yet no single individual could possibly hope to keep a detailed track of this flood of information." All of this knowledge has to be sorted, meaningfully correlated, and continually refined to ultimately benefit patients. Ever since the Centre's founding four years ago, the LCSB scientists have made it a point to develop this disease overview and put it in a useful format of an interactive map available to both researchers and clinicians. In developing the map, the LCSB scientists worked closely with their colleagues at the Systems Biology Institute (SBI) in Tokyo, Japan. The SBI researchers already creat
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Contact: Sabine Mosch
sabine.mosch@uni.lu
352-466-644-6423
University of Luxembourg
Source:Eurekalert  

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