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PBS-Bio works with 3 new firms to accelerate cancer drug development
Date:10/20/2010

tural control over cancer cell growth."

Although initially focused on lung and pancreatic cancer, Yarger said, "Our data supports the notion that NDC-1308 may control the growth of many kinds of aggressively growing cancers. We hope to further verify this data with PBS-Bio's technology."

Revalesio

Revalesio is targeting inflammation associated with various inflammatory mediated diseases, including cancer, through the creation of charged-stabilized nanostructures, or CSNs.

CSNs are aqueous based nano-bubble cores surrounded by an ionic scaffolding stabilized with free energy. CSNs interact with cells, specifically nave immune cells, altering the surface of the cell membrane and preventing unwanted downstream cellular activity that causes inflammation.

"We're developing a new technology that has novel anti-inflammatory effects applicable to a broad range of diseases," said Dr. Richard Watson, Director of Revalesio's Clinical Science. This technology is under development for the treatment of asthma, cardiovascular disease, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and other inflammatory mediated diseases.

"The charged-stabilized nanostructure is a platform from which we can create a variety of products as combination therapies or standalone therapeutics," Dr. Watson said. "Working with PBS-Bio, we want to see how our technology alters cell-survival in a number of different cancer lines, specifically looking at the connection of specific signaling pathways to inflammatory processes and proliferation signaling in oncology."

Unibioscreen

At hospitals in Belgium and the Netherlands, Unibioscreen has begun phase 1 clinical trials first in human tests with a drug called UNBS1450.

The drug is a hemi-synthetic derivative of a compound identified by Unibioscreen in the root bark of an African plant called Calotropis procera. Pre-clinical tests have shown t
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Contact: Dr. Edward Smith
edsmith@pbs-bio.com
602-418-9300
The Translational Genomics Research Institute
Source:Eurekalert

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