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P&G Beauty & Grooming presents advancements in skin care at AAD Annual Meeting
Date:3/5/2010

y subjects. In intrinsically and extrinsically aged skin, the epidermal cholesterol, fatty acid and sphingolipid synthetic pathway genes were down-regulated. Skin equivalents treated with hexamidine showed the opposite effect, with up-regulation of these pathways. Researchers concluded that the down-regulation of these pathways is consistent with previously reported global decreases in SC lipids in aging skin, and likely contributes to the decreased ability of aged skin to maintain and repair the skin barrier. By increasing the expression of genes involved in lipid biosynthetic pathways, hexamidine has the potential to increase the levels of these key lipids available for skin maintenance and repair. Thus, using hexamidine, P&G Beauty & Grooming scientists significantly increased expression of pathways essential for the production of lipids such as cholesterol, sphingolipids and fatty acids that have the potential to restore the stratum corneum and moisture content of aging skin.

Effect of Anti-Aging Products on Stratum Corneum Thickness and Barrier Integrity (P1009)

The outer layer of the skin, known as the stratum corneum (SC), helps keep the skin hydrated by absorbing moisture and preventing water evaporation. P&G Beauty & Grooming scientists used Confocal Raman Microspectrometry (CRM) and Transepidermal Water Loss (TEWL) measurements to assess the effect of three different anti-aging products on SC thickness. The products tested included a moisturizing cream containing niacinamide and hexamidine, a moisturizing serum containing niacinamide, Lys'lastine, peptides and caffeine and a lotion containing alpha lipoic acid. After four weeks of treatment, study results demonstrated that the SC thickened relative to baseline with each product. The niacinamide/hexamidine cream and niacinamide/Lys'lastine serum both produced statistically significant plumping of the SC relative to no treatment and treatment with the niacinamide/Lys'lastine serum thicke
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Contact: Megan Lustig
mlustig@spectrumscience.com
202-955-6222
Spectrum
Source:Eurekalert

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