Navigation Links
Oxygen levels increase and decrease the effectiveness of anti-inflammatory therapies
Date:12/2/2013

Bethesda, MDA new research discovery published in the December 2013 issue of the Journal of Leukocyte Biology yields an important clue toward helping curb runaway inflammation. Oxygen levels play a critical role in determining the severity of the inflammatory response and ultimately the effectiveness of anti-inflammatory drugs. This research could have significant future benefits for patients with severe asthma, COPD, rheumatoid arthritis, pulmonary fibrosis and coronary artery disease.

According to John Marwick from the MRC Centre for Inflammation Research at The Queen's Medical Research Institute at the University of Edinburgh Medical School in Edinburgh, Scotland, and a researcher involved in the work, "Inflammatory diseases contribute to countless deaths and suffering of people. We hope that by understanding the processes involved in inflammation we will herald the arrival of new and targeted anti-inflammatory drugs that have fewer side effects than what is currently available."

To make this discovery, researchers isolated neutrophils, the immune cells that are responsible for acute inflammation, from the blood of healthy volunteers and incubated them in different levels of oxygen. They then added substances that are usually present at sites of inflammation in humans, both with and without anti-inflammatory glucocorticoid drugs and studied what effect these factors had on neutrophil lifespan. They found that the oxygen levels altered the effectiveness of the drugs, which suggests that these drugs may be less effective for some diseases than they are for others. Future areas of research include developing a deeper understanding of exactly how these drugs work under different conditions to ultimately help with development of new, better tolerated anti-inflammatory therapies.

"This report may shed light on why some people respond better to anti-inflammatory drugs than others, and it suggests that a one size fits all strategy to anti-inflammatory drugs may be overly simplistic. This work could be a foundation to identifying ways to tailor anti-inflammatory agents to specifically treat different diseases," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Oxygen, phosphorous and early life on Earth
2. Studies in Cell Transplantation investigate oxygens impact as a factor in transplantation
3. Low oxygen levels may decrease life-saving protein in spinal muscular atrophy
4. How bacteria change movement direction in response to oxygen: Molecular interactions unravelled
5. Scientists study the catalytic reactions used by plants to split oxygen from water
6. Diabetes Research Institute develops oxygen-generating biomaterial
7. Low levels of blood calcium in dairy cows may affect cow health and productivity, MU study finds
8. Despite menu changes, calorie and sodium levels in chain restaurant entrees remain the same overall
9. Safe levels of environmental pollution may have long-term health consequences
10. Mercury levels in Pacific fish likely to rise in coming decades
11. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2017)... , March 20, 2017 PMD Healthcare announces ... spirometer and Wellness Management System (WMS), a remote, real-time ... in 2010, PMD Healthcare is a Medical Device, Digital ... mission dedicated to creating innovative solutions that empower people ... that intent focus, PMD developed the first ever personal ...
(Date:3/7/2017)... March 7, 2017 Brandwatch , the leading social ... The Prince,s Trust to uncover insights to support its reporting, ... The UK,s leading youth charity will be using Brandwatch ... and get a better understanding of the topics and issues that ... ...
(Date:3/2/2017)... LONDON , March 2, 2017 Who ... infringement lawsuits? Download the full report: https://www.reportbuyer.com/product/4313699/ ... ON THE FINGERPRINT SENSOR FIELD? Fingerprint sensors using ... smartphones. The fingerprint sensor vendor Idex forecasts an increase ... in mobile devices and of the fingerprint sensor market ...
Breaking Biology News(10 mins):
(Date:3/22/2017)...  RXi Pharmaceuticals Corporation (NASDAQ: RXII), a clinical-stage ... unmet medical needs, today announced Alexey Eliseev ... at the 5th Annual Cancer BioPartnering & Investment ... present to and meet with thought leaders from ... as well as institutional investors. This event will ...
(Date:3/20/2017)... ... March 20, 2017 , ... ... interfere with the ability of endogenous hormones to regulate homeostasis via their ... activity (antagonists), EDCs produce adverse reproductive, neurological, proliferative, and immunological disorders. EDC ...
(Date:3/20/2017)... ... March 20, 2017 , ... Existing methods using ... in order to reduce the impact on instrumentation. ICP-MS is a robust and ... analysis. , This presentation will discuss the pros and cons of using ...
(Date:3/20/2017)... ... March 20, 2017 , ... Park Systems, a leader ... on Friday, March 24, 2017 from 5-7pm at their Santa Clara facility that ... presentation from imec Senior Researcher, Dr. Tae-Gon Kim. , Dr. Tae-Gon Kim, Senior researcher ...
Breaking Biology Technology: