Navigation Links
Oxygen levels increase and decrease the effectiveness of anti-inflammatory therapies

Bethesda, MDA new research discovery published in the December 2013 issue of the Journal of Leukocyte Biology yields an important clue toward helping curb runaway inflammation. Oxygen levels play a critical role in determining the severity of the inflammatory response and ultimately the effectiveness of anti-inflammatory drugs. This research could have significant future benefits for patients with severe asthma, COPD, rheumatoid arthritis, pulmonary fibrosis and coronary artery disease.

According to John Marwick from the MRC Centre for Inflammation Research at The Queen's Medical Research Institute at the University of Edinburgh Medical School in Edinburgh, Scotland, and a researcher involved in the work, "Inflammatory diseases contribute to countless deaths and suffering of people. We hope that by understanding the processes involved in inflammation we will herald the arrival of new and targeted anti-inflammatory drugs that have fewer side effects than what is currently available."

To make this discovery, researchers isolated neutrophils, the immune cells that are responsible for acute inflammation, from the blood of healthy volunteers and incubated them in different levels of oxygen. They then added substances that are usually present at sites of inflammation in humans, both with and without anti-inflammatory glucocorticoid drugs and studied what effect these factors had on neutrophil lifespan. They found that the oxygen levels altered the effectiveness of the drugs, which suggests that these drugs may be less effective for some diseases than they are for others. Future areas of research include developing a deeper understanding of exactly how these drugs work under different conditions to ultimately help with development of new, better tolerated anti-inflammatory therapies.

"This report may shed light on why some people respond better to anti-inflammatory drugs than others, and it suggests that a one size fits all strategy to anti-inflammatory drugs may be overly simplistic. This work could be a foundation to identifying ways to tailor anti-inflammatory agents to specifically treat different diseases," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.


Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Related biology news :

1. Oxygen, phosphorous and early life on Earth
2. Studies in Cell Transplantation investigate oxygens impact as a factor in transplantation
3. Low oxygen levels may decrease life-saving protein in spinal muscular atrophy
4. How bacteria change movement direction in response to oxygen: Molecular interactions unravelled
5. Scientists study the catalytic reactions used by plants to split oxygen from water
6. Diabetes Research Institute develops oxygen-generating biomaterial
7. Low levels of blood calcium in dairy cows may affect cow health and productivity, MU study finds
8. Despite menu changes, calorie and sodium levels in chain restaurant entrees remain the same overall
9. Safe levels of environmental pollution may have long-term health consequences
10. Mercury levels in Pacific fish likely to rise in coming decades
11. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
Post Your Comments:
(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
(Date:4/5/2017)... Today HYPR Corp. , leading innovator ... of the HYPR platform is officially FIDO® Certified ... architecture that empowers biometric authentication across Fortune 500 enterprises ... over 15 million users across the financial services industry, ... product suites and physical access represent a growing portion ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... Proscia Inc ., a data solutions ... “Pathology is going digital. Is your lab ready?” with Dr. Nicolas Cacciabeve, Managing ... how Proscia improves lab economics and realizes an increase in diagnostic confidence.* ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer ... treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and bind ...
(Date:10/10/2017)... Parks Associates announced today that Tom Kerber , Director ... , October 11 in Scottsdale, Arizona . Kerber will ... safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the introduction of ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series will ... American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population estimates ... of how to continue to feed a growing nation. At the same time, many ...
Breaking Biology Technology: