Navigation Links
Oxidative stress and altered gene expression occurs in a metabolic liver disease model
Date:10/29/2012

A team of researchers under the direction of Dr. Jeffrey Teckman in the Department of Pediatrics at St. Louis University, have demonstrated that oxidative stress occurs in a genetic model of alpha-1-antitrypsin deficiency. This is the most common genetic liver disorder in children and can lead to cirrhosis and hepatocellular carcinoma in adults. Some cases may require liver transplantation. The report, published in the October 2012 issue of Experimental Biology and Medicine, suggests that treatment with antioxidants might be of therapeutic benefit for some individuals.

"We have evidence of oxidative stress in livers from an animal model that expresses the classical Z variant form of alpha-1-antitrypsin. The animal model recapitulates the human liver disease, in which the livers accumulate polymers of alpha-1-antitrypsin mutant Z protein, developing fibrosis and hepatocellular carcinoma with age", says Dr. Marcus. Potentially, non-invasive treatment involving long-term regulation of antioxidant levels could ameliorate the oxidative stress and retard the advancement of disease.

"This is an exciting new report which may help us understand the extreme variability between different patients with this same, single gene, metabolic liver disease. These findings may inform the pathophysiology of other liver diseases as well", says Dr. Teckman. In clinical studies, liver disease from alpha-1-antitrypsin mutant Z protein has shown considerable variability in severity and progression, suggesting that as yet undescribed genetic modifiers may influence disease development. Based on this study, certain antioxidant enzymes involved in oxidative stress defense could be useful targets for further examination. Using microarray technology, the investigators have identified a number of potential alterations in gene expression pathways that could modify the development of liver pathologies. This information could be useful in defining genetic variants that may influence individual susceptibility and in facilitating the design of appropriate treatments.

Steven R. Goodman, PhD, Editor-in-Chief of Experimental Biology and Medicine said, "Teckman and colleagues have demonstrated that oxidative stress occurs in an animal model of Alpha-1-antitrypsin deficiency. This suggests that antioxidant treatment may be beneficial in this most common genetic liver disorder in children."
'/>"/>

Contact: Dr. Nancy Marcus
nmarcus@slu.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

Related biology news :

1. Red hair is a sign of oxidative stress in wild boars, but gray is a-ok
2. Wake Forest Baptist Offers Tips on How to Avoid and Relieve Campaign Season Stress
3. Oyster genome uncover the stress adaptation and complexity of shell formation
4. Relieving plant stress could eventually help humans relax
5. UMD study shows exercise may protect against future emotional stress
6. Low ghrelin -- reducing appetite at the cost of increased stress?
7. Stress hormones: Good or bad for posttraumatic stress disorder risk?
8. Ecosystems cope with stress more effectively the greater the biodiversity
9. New method: Research team analyzes stress biology in babies
10. Acute stress alters control of gene activity
11. For young birds, getting stressed out can be a good thing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2016)... 2016 http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the ... Market 2016-2020"  report to their offering. ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the addition ...
(Date:1/21/2016)... 21, 2016 --> ... market research report "Emotion Detection and Recognition Market by Technology ... (Facial Expression, Voice Recognition and Others), Services, Application ... to 2020", published by MarketsandMarkets, the global Emotion ... USD 22.65 Billion by 2020, at a CAGR ...
(Date:1/20/2016)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce the attainment of record-setting ... result of the company,s laser focus on (and growing ... it,s comprehensive, easy-to-use and highly affordable cloud-based technology platform. ... MedNet growth achievements in 2015 include: , ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... ... 03, 2016 , ... ZeptoMetrix™ Corporation (ZMC), announced today the ... quality control of molecular assays targeting the Zika Virus. , “Our level of ... President and CEO of ZeptoMetrix, relayed to his Executive Team. “We need to ...
(Date:2/3/2016)... ... February 03, 2016 , ... Marktech Optoelectronics, ... and wafers, and InP epi wafers based in Latham, New York, offers a ... transistors, and Avalanche photodiodes–to Si and InGaAs PIN photodiodes. But it is Marktech's ...
(Date:2/2/2016)... NY (PRWEB) , ... February ... ... a business-to-business publication dedicated to delivering cutting-edge information focused on the development ... to become a premier sponsor of the 2016 BioProcess International Awards – ...
(Date:2/2/2016)... , Feb. 2, 2016 Sangamo BioSciences, ... genome editing, today announced that the company will release ... after the market closes on Tuesday, February 9, 2016. ... call at 5:00 p.m. ET, which will be open ... conference call, the company will review the quarter,s financial ...
Breaking Biology Technology: