Navigation Links
Oxidative stress: Less harmful than suspected?
Date:12/5/2011

Arterial calcification and coronary heart disease, neurodegenerative diseases such as Parkinson's and Alzheimer's, cancer and even the aging process itself are suspected to be partially caused or accelerated by oxidative stress. Oxidative stress arises in tissues when there is an excess of what are called reactive oxygen species (ROS). "However, up to now, nobody was able to directly observe oxidative changes in a living organism and certainly not how they are connected with disease processes," said Associate Professor (PD) Dr. Tobias Dick of DKFZ. "There were only fairly unspecific or indirect methods of detecting which oxidative processes are really taking place in an organism."

For the first time, Tobias Dick and his co-workers have been able to observe these processes in a living animal. Jointly with Dr. Aurelio Teleman (also of DKFZ), they introduced genes for biosensors into the genetic material of fruit flies. These biosensors are specific for various oxidants and indicate the oxidative status of each cell by emitting a light signal in realtime, in the whole organism and across the entire life span.

In the fly larvae, the investigators already discovered that oxidants are produced at very differing levels in different tissue types. Thus, blood cells produce considerably more oxidants in their energy plants, the mitochondria, than, for example, intestinal or muscle cells. In addition, the larvae's behavior is reflected in the production of oxidants in individual tissues: The researchers were able to distinguish whether the larvae were eating or moving by the oxidative status of the fat tissue.

Up to now, many scientists have assumed that the aging process is associated with a general increase in oxidants throughout the body. However, this was not confirmed by the observations made by the investigators across the entire life span of the adult animals. They were surprised that almost the only age-dependent increase in oxidants
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Thymoquinone induced oxidative stress targets highly aggressive prostate cancers
2. Flavonoids in orange juice suppress oxidative stress from high-fat, high-carb meal
3. New method monitors early sign of oxidative stress in cancer
4. Study of huge numbers of genetic mutations point to oxidative stress as underlying cause
5. HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
6. Understanding how oxidative stress impairs endothelial progenitor cell function
7. The leading edge of stress: New genomic, optogenetic and epigenetic findings
8. First study to reveal how paracetamol works could lead to less harmful pain relief medicines
9. Drinking water from plastic pipes - is it harmful?
10. Can aromatherapy produce harmful indoor air pollutants?
11. Home washing machines: Source of potentially harmful ocean microplastic pollution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... protected 100 percent of animal models against the highly ... causes an intestinal disease that kills approximately 30,000 Americans ... Infection and Immunity . , In the ... against the purified toxins produced by C. difficile ... a laboratory model that mimics the human disease, after ...
(Date:7/31/2014)... better identify and treat those with fibromuscular dysplasia (FMD). ... sized arteries in the body, which can restrict blood flow ... new report appearing in August 2014 issue of ... FMD may not be limited to the arteries as currently ... bones and joints, as well as evidence that inflammation may ...
(Date:7/31/2014)... they are an iconic symbol of tropical resorts ... landscape. Some, like Hawaii,s State Flower- Hibiscus ... relatively few botanists and Hawaiian conservation workers, however, ... related group of plants known as Hibiscadelphus ... Hibiscus species are in fact highly endangered. Until ...
Breaking Biology News(10 mins):C. difficile vaccine proves safe, 100 percent effective in animal models 2Scientists discover biochemical mechanisms contributing to fibromuscular dysplasia 2Brother of Hibiscus is found alive and well on Maui 2
... developed a slow-release anesthetic drug-delivery system that could ... surgery, and may also have a large impact ... used specially designed fat-based particles called liposomes to ... local anesthesia in rats without apparent toxicity to ...
... Climate change will cause some of Australia,s potential weeds to ... by scientists at CSIRO,s Climate Adaptation Flagship. Weeds cost ... or lost production and cause serious damage to the environment. ... GREENHOUSE 09 conference on climate change, CSIRO researcher, Dr John ...
... Fast food and soft drinks may be making children fatter ... tackling childhood obesity, by reducing children,s consumption of unhealthy food ... also actively seek to keep children happy in other ways, ... Professor Rodolfo Nayga from the University of Arkansas in the ...
Cached Biology News:Long-lasting nerve block could change pain management 2Climate change may wake up 'sleeper' weeds 2Eat, drink and be merry? 2
(Date:8/1/2014)... BCC Research ( http://www.bccresearch.com ) reveals in ... GLOBAL MARKETS , that the global market RNA interference ... nearly $38.8 billion by 2018, with a five-year compound ... category, the fastest moving segment of the market, is ... of RNAi therapeutics has shown tremendous growth and has ...
(Date:8/1/2014)... Aug. 1, 2014 Glencoe Software, ... of "Data InPress" ( http://glencoesoftware.com/data-inpress.html ), a ... multidimensional image data into on-line publications.  The ... Video Injection Service. Photo - ... http://photos.prnewswire.com/prnh/20140731/132409 The DataViewer ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Food ... are increasingly searching for food alternatives that offer ... benefits. The food ingredient market has numerous players ... such as Vital Force Technology (VFT). VFT ... than 4,000 energetic patterns, all tested to produce ...
(Date:7/31/2014)... , the leading life sciences employment and news website, launched the ... Illinois , Indiana , ... , Minnesota , Missouri , ... Wisconsin . BioMidwest is a leader in biotech and ... in this region in 2013. The life sciences sector in this area ...
Breaking Biology Technology:Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 2Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 3Glencoe Software Launches Data InPress 2Glencoe Software Launches Data InPress 3Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2Midwest Biotech Leaders Featured On BioSpace Map 2
... To validate any RNAi experiment, target mRNA , ... using a positive control siRNA that is known to be effective, , ... , Validation is also necessary ... effectiveness and potency of any siRNA sequence. Finally, , ...
... Microarrays , ... engineered to maximize yields of full-length cDNA , ... 100 ng of input RNA in a single round for GeneChip , ... cRNA synthesis powered by , MEGAscript, the best ...
... Total RNA Isolation from Formalin Fixed Paraffin Embedded (FFPE) Tissues , ... Phenol-free isolation of total RNA from , FFPE tissues , ... href="http://www.ambiondx.com/products/optimum/index.html">Optimum , ... and rapid protocol , for ...
Cached Biology Technology:Confirming RNAi Effects Is Now Easier Than Ever 2Confirming RNAi Effects Is Now Easier Than Ever 3Confirming RNAi Effects Is Now Easier Than Ever 4Confirming RNAi Effects Is Now Easier Than Ever 5Improving RNA Amplification 2Improving RNA Amplification 3Improving RNA Amplification 4Improving RNA Amplification 5Improving RNA Amplification 6Improving RNA Amplification 7Improving RNA Amplification 8Improving RNA Amplification 9Improving RNA Amplification 10Improving RNA Amplification 11Improving RNA Amplification 12Improving RNA Amplification 13Improving RNA Amplification 14Optimum FFPE RNA Isolation Kit 2Optimum FFPE RNA Isolation Kit 3Optimum FFPE RNA Isolation Kit 4
Ready for formulation or direct injection into animals Provided in convenient 100, 250, 1000 and 10,000 nmol sizes HPLC purified, salt free, sterile filtered, and endotoxin tested ...
... the premium quality siRNAs you need for ... be readily ordered online by providing either ... providing the sense and antisense siRNA sequences. ... Validated and Silencer Pre-designed siRNAs, ...
GEL FILTRATION CAL KIT HMW, 1 EA. *Category: Gel Filtration Gels....
Mouse monoclonal [6C3] to JAB1 ( Abpromise for all tested applications). entrezGeneID: 10987 SwissProtID: O15386...
Biology Products: