Navigation Links
Oxidative DNA damage repair
Date:12/27/2011

Oxidative stress is the cause of many serious diseases such as cancer, Alzheimer's, arteriosclerosis and diabetes. It occurs when the body is exposed to excessive amounts of electrically charged, aggressive oxygen compounds. These are normally produced during breathing and other metabolic processes, but also in the case of ongoing stress, exposure to UV light or X-rays. If the oxidative stress is too high, it overwhelms the body's natural defences. The aggressive oxygen compounds destroy genetic material, resulting in what are referred to as harmful 8-oxo-guanine base mutations in the DNA.

DNA repair mechanism decoded

Together with the University of Oxford, Enni Markkanen, a veterinarian in the working group of Prof. Ulrich Hbscher from the Institute of Veterinary Biochemistry and Molecular Biology at the University of Zurich has decoded and characterized the repair mechanism for the mutated DNA bases. This mechanism efficiently copies thousands of 8-oxo-guanines without their harmful mutations, thus normally preventing the negative consequences of 8-oxo-guanine damage. In their study, published in PNAS, the researchers outline the detailed processes involved in the local and temporal coordination of this repair mechanism.

Prof. Ulrich Hbscher hopes that this basic research can be used therapeutically. We expect that the DNA repair mechanism discovered here will lead to less invasive approaches in cancer therapy and that it will be possible to develop new clinical tests for the early detection of certain types of cancer. In cooperation with University Hospital Zurich, a study is already underway that involves examining samples of different types of cancer for the repair gene and its regulation.


'/>"/>

Contact: Prof. Ulrich Hbscher, University of Zurich, Veterinary
hubscher@vetbio.uzh.ch
41-446-355-472
University of Zurich
Source:Eurekalert

Page: 1

Related biology news :

1. Oxidative stress: Less harmful than suspected?
2. Thymoquinone induced oxidative stress targets highly aggressive prostate cancers
3. Flavonoids in orange juice suppress oxidative stress from high-fat, high-carb meal
4. New method monitors early sign of oxidative stress in cancer
5. Study of huge numbers of genetic mutations point to oxidative stress as underlying cause
6. HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
7. Understanding how oxidative stress impairs endothelial progenitor cell function
8. New international Ph.D. program on Dynamics of Gene Regulation, Epigenetics and DNA Damage Response
9. Adult stem cells use special pathways to repair damaged muscle, MU researchers find
10. Brain, repair thyself: Studies highlight brains resiliency to damage
11. Scarring a necessary evil to prevent further damage after heart attack
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/29/2017)... 2017  higi, the health IT company that operates ... America , today announced a Series B investment ... EveryMove. The new investment and acquisition accelerates higi,s strategy ... transform population health activities through the collection and workflow ... higi collects and secures data today on behalf of ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... ... May 25, 2017 , ... Throughout this webinar, participants will ... process development and economic goals were achieved in both industry and academic settings. ... system, along with techniques for scaling production of mesenchymal stem cells (MSCs) and ...
(Date:5/24/2017)... BOUNTIFUL, Utah (PRWEB) , ... May 24, 2017 ... ... announces the selection and implementation of CLEARAS Water Recovery’s Advanced Biological Nutrient Recovery ... a key component of a $24 million plant upgrade to sustainably meet current ...
(Date:5/24/2017)... May 23, 2017 As Ebola resurfaces in the ... deaths and 20 suspected cases now reported, a new analysis ... database, showed a correlation between the 2014 and 2017 outbreaks ... rose sharply in 2012-13, which preceded the 2014 outbreak. An ... Ebola gene Replikin counts in 2014-15, which again precedes the ...
(Date:5/23/2017)... ... May 23, 2017 , ... Genedata, a ... anniversary, marking the occasion with a strong presence at Bio-IT World Conference & ... further extends an invitation to all attendees to view posters on the ...
Breaking Biology Technology: