Navigation Links
Overweight? There's a vaccine for that
Date:7/8/2012

New vaccines promote weight loss. A new study, published in BioMed Central's open access journal, Journal of Animal Science and Biotechnology, assesses the effectiveness of two somatostatin vaccinations, JH17 and JH18, in reducing weight gain and increasing weight loss in mice.

Obesity and obesity-related disease is a growing health issue worldwide. Somatostatin, a peptide hormone, inhibits the action of growth hormone (GH) and insulin-like growth factor (IGF-1), both of which increase metabolism and result in weight loss. Vaccination with modified somatostatin causes the body to generate antibodies to somatostatin, effectively removing this inhibition without directly interfering with the growth hormones and subsequently increasing energy expenditure and weight loss.

Keith Haffer from Braasch Biotech LLC, tested the vaccinations in two groups of ten diet-induced obese male mice compared with a control group of ten mice which received saline injections. Mice in all groups had been fed a high fat diet for eight weeks prior to the study and continued to eat the same food for the duration of the six-week study. The vaccinations were administered twice - at the start of the study followed by a booster vaccination on day 22.

Four days after the first injection of modified somatostatin, the vaccinated mice had a 10% drop in body weight (not seen in the control mice). At the end of the study, results showed that both vaccines induced antibodies to somatostatin and significantly reduced body weight, sustaining a 10% lower body weight, without affecting normal levels of the growth hormone IGF-1, or insulin levels.

"This study demonstrates the possibility of treating obesity with vaccination", Keith explained. He continued, "Although further studies are necessary to discover the long term implications of these vaccines, treatment of human obesity with vaccination would provide physicians with a drug- and surgical- free option a
'/>"/>

Contact: Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Page: 1 2

Related biology news :

1. Overweight? New research explains how proper sleep is important for healthy weight
2. Sensitive test helps improve vaccine safety
3. Army study: DNA vaccine and duck eggs protect against hantavirus disease
4. AAPS National Biotechnology Conference to highlight innovative vaccines
5. Researchers identify Achilles heel of dengue virus, target for future vaccines
6. SFU HIV/AIDS vaccine research gets financial boost
7. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
8. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
9. Queens scientists seek vaccine for Pseudomonas infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ... of the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition ... individuals. Facial recognition system measures the overall facial ... edges, mouth, and the distance between eyes. Facial ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) ... Market in India 2015-2019" report to their ... in this market is the adoption of multimodal ... one characteristic of an individual for verification and ...
(Date:12/11/2014)... ST. PAUL, Minn. , Dec. 10, 2014 ... in wireless physiologic monitoring, has released a new ... changing needs of preclinical toxicology researchers. M series, ... to help toxicologists collect the best possible physiologic ... studies. Adding functional endpoints to toxicology ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... been trying to fully understand a particular communication pathway ... and prostate cancers. While scientists have identified elements of ... Researchers at Whitehead Institute now have discovered a missing ... with a significant new cancer target. , "We believe ...
... chromosomes with glass,needles one thousandth the diameter of a ... "stickiness" to one another during,cell division. Her uncanny surgical ... puzzle of how one cell divides into two -- ... issue of Current Biology, Leocadia Paliulis and,Bruce Nicklas report ...
... of scientists has accomplished the daunting task of evaluating ... and the outlook is troubling. , Commissioned by the ... will issue its primary report on March 30 during ... Delhi, Brasilia, Cairo, Nairobi and Rome. More than 2,000 ...
Cached Biology News:Researchers identify target for cancer drugs 2Needling Chromosomes Reveals Cell Division Secret 2Needling Chromosomes Reveals Cell Division Secret 3Scientists collaborate to assess health of global environment 2Scientists collaborate to assess health of global environment 3
(Date:12/19/2014)... , Dec. 18, 2014   ISN has ... Safety Performance Indicators publication series. With data ... activity reported in 2013 within its online contractor management ... safety key performance indicator (KPI) statistics. ... U.S. publication is available in two industry ...
(Date:12/17/2014)... “Never say, ‘I cannot do ... Department of Physics, advises young women pursuing careers ... SPIE Women in Optics 18-month planner ... ask questions.” , In the annual planner, women ... ranging from university professor and laboratory researcher to ...
(Date:12/17/2014)... Texas (PRWEB) December 17, 2014 ... on Global Quartz Tubing industry. For an overview ... definition, classification, application, industry chain structure, industry overview, ... quartz tubing industry has witnessed rapid ... a number of acquisitions. This report mentions quartz ...
(Date:12/17/2014)... 2014  Vermillion, Inc. (NASDAQ: VRML ), ... announced the next step in its expanded strategy to ... with the naming of current Chief Operating Officer, ... while current Chairman of the Board and CEO ... These changes are effective January 1, 2015. ...
Breaking Biology Technology:ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 32020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4
... 12 PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ) ... dividend to stockholders, with part of the proceeds from the ... stockholders owning shares of PDL on December 1, 2009 will ... PDL has a significant amount of convertible securities outstanding, the ...
... Regado Biosciences, a privately held company leading the development ... David Mazzo, PhD, CEO and President, will be presenting ... at the St. Regis Hotel in New York City. ... on Tuesday, November 17 and will include an overview ...
... WaferGen Biosystems, Inc. (OTC Bulletin Board: WGBS), a ... announced that the University of Texas Southwestern Medical ... SmartChip(TM) Nano-dispenser. The Nano-dispenser is used for ... use with WaferGen,s SmartChip(TM) Real-Time PCR System. The ...
Cached Biology Technology:PDL BioPharma Announces Special Dividend Payment 2Regado Biosciences to Present at the Lazard Capital Markets 6th Annual Healthcare Conference on November 17, 2009 2WaferGen Announces that University of Texas Southwestern Medical Center Demonstrates Utility of New SmartChip(TM) Nano-Dispenser with WaferGen's SmartChip(TM) High-throughput Real-Time PCR System 2WaferGen Announces that University of Texas Southwestern Medical Center Demonstrates Utility of New SmartChip(TM) Nano-Dispenser with WaferGen's SmartChip(TM) High-throughput Real-Time PCR System 3WaferGen Announces that University of Texas Southwestern Medical Center Demonstrates Utility of New SmartChip(TM) Nano-Dispenser with WaferGen's SmartChip(TM) High-throughput Real-Time PCR System 4
Mouse polyclonal antibody to PRDM2 - PR domain containing 2, with ZNF domain...
Hepatocyte Differentiation Environment...
Mouse monoclonal [M2II-12] to MRP2 ( Abpromise for all tested applications). entrezGeneID: 1244 SwissProtID: Q92887...
...
Biology Products: