Navigation Links
Overexpression of splicing protein in skin repair causes early changes seen in skin cancer
Date:1/19/2014

Cold Spring Harbor, NY Normally, tissue injury triggers a mechanism in cells that tries to repair damaged tissue and restore the skin to a normal, or homeostatic state. Errors in this process can give rise to various problems, such as chronic inflammation, which is a known cause of certain cancers.

"It has been noted that cancer resembles a state of chronic wound healing, in which the wound-healing program is erroneously activated and perpetuated," says Professor Adrian Krainer of Cold Spring Harbor Laboratory (CSHL). In a paper published today in Nature Structural & Molecular Biology, a team led by Dr. Krainer reports that a protein they show is normally involved in healing wounds and maintaining homeostasis in skin tissue is also, under certain conditions, a promoter of invasive and metastatic skin cancers.

The protein, called SRSF6, is what biologists call a splicing factor: it is one of many proteins involved in an essential cellular process called splicing. In splicing, an RNA "message" copied from a gene is edited so that it includes only the portions needed to instruct the cell how to produce a specific protein. The messages of most genes can be edited in multiple ways, using different splicing factors; thus, a single gene can give rise to multiple proteins, with distinct functions.

The SRSF6 protein, while normally contributing to wound healing in skin tissue, when overproduced can promote abnormal growth of skin cells and cancer, Krainer's team demonstrated in experiments in mice. Indeed, they determined the spot on a particular RNA message one that encodes the protein tenascin C where SRSF6 binds abnormally, giving rise to alternate versions of the tenascin C protein that are seen in invasive and metastatic cancers.

The CSHL team also found that overproduction of SRSF6 in mice results in the depletion of a type of stem cell called Lgr6+. These skin stem cells reside in the upper part of the hair
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Overexpression of cytoglobin gene increases neuronal hypoxic tolerance
2. OGIs investment in cytognomix contributes to the Shannon Human Splicing Pipelines success
3. Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells
4. Lariats: How RNA splicing decisions are made
5. Next-gen reappraisal of interactions within a cancer-associated protein complex
6. Researchers pursuing arthritis protein
7. Some motor proteins cooperate better than others
8. Tiny proteins have outsized influence on nerve health
9. Mass spectrometer detection of 10 protein spots after acute high-altitude HBI
10. How does Rho-associated protein kinase modulate neurite extension?
11. Activating P300 protein contributes to repair of hippocampal neuronal DNA injuries
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Overexpression of splicing protein in skin repair causes early changes seen in skin cancer
(Date:12/22/2014)... (NASDAQ: NXTD and NXTDW) ("NXT-ID" or the ... commerce market, announces it has retained famous pickpocket, entertainer and ... CES debut of the Wocket™ biometric smart wallet.  ... booth January 6th and 7 th , 2015, demonstrating some ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has ... Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report" ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition of ... feature with the iPhone 5S. It is currently the ...
(Date:12/19/2014)... 2014   LaunchKey , the first decentralized mobile authentication ... of Things era, today announced the close of $3 ... led by Metamorphic Ventures with participation from ENIAC Ventures, ... others.  LaunchKey has raised $4 million to date, and ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... have long known that people who have a close relative ... to abuse alcohol. The reason for this has not been ... Sweden, provides part of the answer. The study shows that ... react more positively to alcohol than other people. , The ...
... Laboratory studies by chemical engineers at UC Santa ... detection and diagnosis and to possible treatments ... and similar diseases. Achieving a new method of ... the membrane surrounding nerves that is compromised in patients ...
... Administration requires every drug they certify to be tested ... gold standard for this is the limulus amoebocyte lysate ... crabs, which strangely enough is blue, to test for ... by bacterial infections. But researchers at the Department ...
Cached Biology News:Heredity behind subjective effects of alcohol 2New nanoscale imaging may lead to new treatments for multiple sclerosis 2Replacing the blue bloods 2
(Date:12/25/2014)... The report “Service Quality Management and Telco Customer Experience ... Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and ... of revenues. , Browse 152 market data tables, ... on “Service Quality Management (SQM) and Telco Customer Experience ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
(Date:12/24/2014)... St. Louis, Missouri (PRWEB) December 23, 2014 ... Swiss biotechnology company, Syngenta, are in the process of being ... consolidated case is In Re: Syngenta AG MIR 162 Corn ... the District of Kansas. , Management of the Syngenta GMO ...
(Date:12/24/2014)... On Friday, December 19, 2014, President ... Continuing Resolution Appropriations Act of 2015, which for the ... funding through the Congressionally Directed Medical Research Programs (CDMRP) ... Association (HA), working in conjunction with its allies on ...
Breaking Biology Technology:Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... HONG KONG, Oct. 1 /PRNewswire-Asia/ -- Golden Meditech Company ... a leading hi-tech medical device and healthcare service corporation ... Golden Meditech Hospital Group (GMHG) has entered into an ... in 2014 with an aggregate principal amount of US$28 ...
... ... Academia to Come Together for Virtual Conference and Networking at www.BioConferenceLive.com , ... Boston, MA (PRWEB) -- PlatformQ ... LabRoots , a free social networking site serving the scientific community, today announced that ...
... DOR BioPharma, Inc. (OTC Bulletin Board: SNGX), a late-stage biotechnology ... change from DOR BioPharma, Inc. to Soligenix, Inc. (Soligenix or ... Company,s shares of common stock will immediately begin trading under ... , "We are pleased to announce the name change of ...
Cached Biology Technology:Golden Meditech Announces HK$217 Million Private Equity Financing for Hospital Subsidiary 2CEO of Burrill & Company to Speak at BioConference Live Slated for November 17th and 18th 2CEO of Burrill & Company to Speak at BioConference Live Slated for November 17th and 18th 3DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 2DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 3DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 4
Potassium Channel kv3.2...
200 μg per ml DNA in 10 SSPE, 2 Denhardt's...
MagSi uniform silica particles coated with a carboxyl group containing polymer, covalently attached to the bead surface....
MAb to Vasopressin Preservative: NaN3...
Biology Products: