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Overeating and obesity triggered by lack of BDNF
Date:12/27/2007

pears that this signaling pathway acts, at least partly, through short-term mechanisms and that BDNF synthesis in the VMH and DMH is required for suppression of appetite.

While she notes that additional studies are needed to further pinpoint the cellular and molecular targets of BDNF action, Rios says, This work brings us closer to elucidating the brain pathways that rely on BDNF to modulate food intake. She adds that the relevance of the BDNF signaling pathway in human disease is highlighted by the obesity exhibited by certain humans carrying mutations or abnormalities in the genes coding for BDNF or its receptor. This is bound to be an important area of obesity research as more than a quarter on the American population has been estimated to carry mutations in the Bdnf gene.


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Contact: Siobhan Gallagher
siobhan.gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert

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