Navigation Links
Overeating and obesity triggered by lack of BDNF
Date:12/27/2007

BOSTON (December 27, 2007) According to the Centers for Disease Control and Prevention, close to one-third of the population in the United States is obese and another third is overweight. Excessive weight gain is elicited by alterations in energy balance, the finely modulated equilibrium between caloric intake and expenditure. But what are the factors that determine how much food is consumed" Part of the mystery is unfolding in the laboratory of Maribel Rios, PhD, at the Sackler School of Graduate Biomedical Sciences at Tufts University School of Medicine in Boston. Through their work, Rios and colleagues have demonstrated for the first time that a protein called brain-derived neurotrophic factor (BDNF) is critical in mediating satiety in adult mice. Their findings are published in the December 26 issue of The Journal of Neuroscience.

Mice in which the Bdnf gene was deleted in two of the primary appetite-regulating regions of the brain ate more and became significantly heavier than their counterparts. Prior to this study, we knew that the global lack of BDNF and/or its receptor during development leads to overeating and obesity in young mice. However, it remained unclear and controversial whether BDNF mediated satiety in adult animals. Our recent findings demonstrate that BDNF synthesis in the ventromedial (VMH) and dorsomedial hypothalamus (DMH) is required for normal energy balance. Additionally, because the mice examined in this study were genetically altered in adulthood, we were able to establish that BDNF acts as a satiety signal in the mature brain independently from its putative actions during development of the brain. This important distinction might help define disease mechanisms and critical periods of intervention for the treatment and prevention of obesity disorders, says Rios, corresponding author and an assistant professor of neuroscience at the Sackler School.

The obesity exhibited by BDNF-depleted mice appears to arise solely
'/>"/>

Contact: Siobhan Gallagher
siobhan.gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. Obesity and lack of exercise could enhance the risk of pancreatic cancer
3. Obesity and the central nervous system -- the state of the art
4. Obesity-related hormone is higher in children with Down syndrome
5. Australian researchers develop treatment to treat obesity
6. Study suggests link between obesity, poor bone health
7. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... to what was previously thought, newborn immune T cells ... to bacteria, according to a new study led by ... differently to that of adults, babies may still be ... study published in the journal Nature Medicine . ... different types of immune cells, including neutrophils which play ...
(Date:9/19/2014)... today by researchers from several Harvard University labs ... experienced and aspiring researchers with the intellectual raw ... made from soft, flexible materials. , With the ... other advances in manufacturing technology, soft robotics is ... drawn from conventional rigid robot design, but working ...
(Date:9/19/2014)... Imagine you are a species which over thousands of years ... exposed to a substance that makes the cold dangerous for ... Enchytraeus albidus , and the cold provoking substance, called ... cosmetics. , Nonylphenol is suspected of being a endocrine disruptor, ... It inhibits the worm,s ability to protect the cells in ...
Breaking Biology News(10 mins):Immune system of newborn babies is stronger than previously thought 2Soft robotics 'toolkit' features everything a robot-maker needs 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3
... were not the only ones with visions of sugar plums ... a new research report published in the January 2010 issue ... ), a team of scientists from the University of Texas ... compound from licorice root (glycyrrhizin from Glycyrrhiza glabra ) ...
... DALLAS Jan. 4, 2010 An experimental drug currently ... fighting the brain cancer glioblastoma and prostate cancer, researchers at ... The drug,s actions, observed in isolated human cells in ... encouraging because they attacked not only the bulk of the ...
... origin of the Devil Facial Tumour Disease (DFTD) that has ... scientists has discovered. Devil Facial Tumour Disease (DFTD) ... was first reported in 1996. It is spread by biting ... large tumours, mostly on the face and mouth, which often ...
Cached Biology News:A trip to the candy store might help ward off rare, but deadly infections 2Experimental drug shows promise against brain, prostate cancers 2Nervous culprit found for Tassie devil facial tumor disease 2
(Date:9/22/2014)... Pa. (PRWEB) September 22, 2014 ... rapid diagnostics for the food and beverage industries, ... will be distributed under a non-exclusive agreement by ... and services. , Enartis, an Esseco Group company ... to winemakers in California and other global markets ...
(Date:9/22/2014)... Sept. 22, 2014  WIRB-Copernicus Group (WCG), the ... services for clinical research, announced today that its ... been reaccredited by the Association for the Accreditation ... to improve safeguards for clinical research participants. ... Deieso , Ph.D., commented, "It is of utmost ...
(Date:9/22/2014)... 22, 2014  Spherix Incorporated (SPEX) -- an intellectual property ... property, today announced that the United States Patent & Trademark ... the month of September that is part of a standard ... is: USRE45,121 , Application number: US 13/728,867 ... Dec 27, 2012 The listed inventors of ...
(Date:9/20/2014)... and PITTSFIELD, Massachusetts, USA (PRWEB) September 20, 2014 ... for the prestigious 2015 Prism Awards for Photonics ... product inventions from the multi-billion dollar optics and photonics ... society for optics and photonics , and Photonics ... as well as the versatility of photonics, said SPIE ...
Breaking Biology Technology:Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 2Invisible Sentinel's Test for Wine-Spoilage Microbe to be Distributed by Enartis in Multiple Markets Globally 3Western IRB (WIRB) Awarded AAHRPP Reaccreditation 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3Entry deadline is 10 October for international photonics Prism Awards 2Entry deadline is 10 October for international photonics Prism Awards 3Entry deadline is 10 October for international photonics Prism Awards 4
... West Central Wisconsin Workforce Resource is inviting representatives ... Synergy Conference titled "Positioning for Economic Growth." , ,The conference ... a.m. to 5 p.m. and Sept. 21 from 8 a.m. ... Memorial Student Center . , ,Although some speakers have ...
... - Mithridion, Inc. , a biopharmaceutical startup that is ... secured $296,800 in federal grants to evaluate tests for drug ... Institute on Aging , a branch of the U.S. ... the feasibility of the tests. If successful, the company will ...
... Wis. - The recent decision by a young researcher ... some of the financial consequences of the same-sex union debate ... and nanotechnology researcher, has won $3.4 million in grants since ... year, he will take his knowledge and research with him ...
Cached Biology Technology:Conference to address small town development 2Mithridion wins grants for Alzheimer's research 2Mithridion wins grants for Alzheimer's research 3Departure of nanotech researcher stings UW 2Departure of nanotech researcher stings UW 3
Rabbit polyclonal to Shigella (HRP) ( Abpromise for all tested applications)....
... PhosphoPlus™ SAPK/JNK (Thr183/Tyr185) Antibody Kit ... (Thr183/Tyr185) Antibody, Catalog #9251, 200 ul ... 200 ul SAPK/JNK Cell Extracts, Catalog ... HRP-linked Antibody, Catalog #7074, 100 ul ...
Anti-gp120/160(SIV/mac239) Immunogen: gp120(SIV/mac239) protein (Genebank accession #M33262)...
Annexin V Binding Buffer, 10X Concentrate Buffer , 50 ml Consult technical datasheet for details....
Biology Products: