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Overcoming anthrax bacterium's natural defenses could hold key to new treatments
Date:5/18/2010

ed by the anthrax bacterium is vital to developing medical countermeasures against it."

Anthrax most commonly occurs in wild and domestic mammals, although it has the potential to be used as a biological threat agent. Symptoms vary depending on the route of exposure; however, mild fever, fatigue and muscle aches usually begin within 4-6 days of exposure. As the bacteria multiply in the lymph nodes, toxemia progresses and the potential for widespread tissue dissemination, destruction and organ failure increases. Severe breathing difficulty, meningitis and shock can follow. Up to 90 percent of untreated cases of inhalational anthrax result in death.

"This study provides significant insight into the pathogenesis of anthrax infection, tracing the connection between B. anthracis gene expression to its effect on host response," said Colonel John P. Skvorak, commander of USAMRIID.


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Contact: Caree Vander Linden
Caree.VanderLinden@us.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
Source:Eurekalert

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