Navigation Links
Overcoming anthrax bacterium's natural defenses could hold key to new treatments
Date:5/18/2010

Army scientists have discovered a way to "trick" the bacterium that causes anthrax into shedding its protective covering, making it easier for the body's immune system to mount a defense. The study, which appears in this month's issue of the journal MICROBIOLOGY, could lead to new approaches for treating anthrax infection.

Bacillus anthracis, the causative agent of anthrax, is particularly lethal because of its protective coating, or capsule, which enables the pathogen to escape destruction by the host's immune system. A key bacterial enzyme called capsule depolymerase, or CapD, anchors the capsule to the cell surface. CapD also cuts and releases part of the capsule into small fragments that are thought to interfere with specific parts of the immune system, offering further protection to the bacterium. The rest of the capsule remains intact.

Finding a way to cause B. anthracis to unmask itself, using the bacterium's own machinery, would be a novel approach to defeating the pathogen. So scientists at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) induced B. anthracis to make higher-than-normal amounts of CapD, resulting in release of the capsule fragments. This left very little capsule attached to the bacterial cells. As a result, the unprotected bacteria were left vulnerable to immediate detection and destruction by the cells of the immune system.

"By engineering B. anthracis to over-produce CapD, we are effectively turning the bacterium's own weapon on itself," explained Dr. Arthur Friedlander, one of the study's principal investigators. He believes the USAMRIID group's findings could have significant clinical impact.

"Many pathogenic bacteria, including B. anthracis, produce a capsule surrounding them that prevents the infected host from killing them, improving their chances of causing disease," he explained. "Understanding the mechanisms of virulence us
'/>"/>

Contact: Caree Vander Linden
Caree.VanderLinden@us.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
Source:Eurekalert

Page: 1 2

Related biology news :

1. Overcoming Taboos, Myths, and Dogmas in Bioethics
2. Einstein scientists move closer to a safer anthrax vaccine
3. Single host gene may hold key to treating both ebola and anthrax infections
4. Early detection and quick response are key to defense against anthrax attack
5. Data published in the New England Journal of Medicine support use of raxibacumab (ABthrax) for the treatment of inhalation anthrax
6. Novel handheld device detects anthrax with outstanding accuracy and reliability
7. New technique used to profile anthrax genome
8. FBI unveils science of anthrax investigation
9. NIST, Army researchers pave the way for anthrax spore standards
10. New decontamination system kills anthrax rapidly without lingering effects
11. Anthrax cellular entry point uncovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 18, 2014  23andMe, Inc., the leading personal genetics ... pinpoints fine-scale differences in genetic ancestry of individuals from ... Since immigrants first arrived more than four hundred ... has served as a meeting place for peoples from ... the ongoing mixing of peoples with African, European, and ...
(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a leader ... PerformTek biometric technology to industry leaders such as Intel, ... clinically validated, biometric wearable products. These products will be ... Las Vegas . ... accurate, flexible and robust – with the clinical data ...
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... their offering. One major trend ... multimodal biometric systems. Multimodal biometric systems utilize more ... and identification purposes. This helps to reduce the ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... has been shown to cause pain by exciting the ... and the hot, spicy ingredient in chili peppers, UCSF ... plants and animals have evolved the same molecular strategy ... specific receptor on sensory nerves. The research provides new ...
... hold promise for reducing the destruction of dopaminergic cells ... lost to the disease, scientists say. , Research ... Neuroscience shows a human neural stem cell transplant essentially ... normally rather than displaying the progressive loss of movement ...
... discovered that mutations in a gene known as SOS1 ... common childhood genetic disorder which occurs in one in ... stature, facial abnormalities, and learning disabilities, as well as ... Led by researchers at Harvard Medical School-Partners Healthcare ...
Cached Biology News:Tarantula venom and chili peppers target same pain sensor 2Transplanted brain cells hold promise for Parkinson's disease 2Transplanted brain cells hold promise for Parkinson's disease 3Study uncovers mutation responsible for Noonan Syndrome 2
(Date:12/24/2014)... (PRWEB) December 23, 2014 Nashville Fertility ... was elected treasurer for the American Society for Reproductive ... knowledge and research in reproductive medicine. In his ... seat on the executive board and will have a ... Dr. Hill has actively supported ASRM since 1984 when ...
(Date:12/24/2014)... 23, 2014 China Biologic Products, Inc. ... leading fully integrated plasma-based biopharmaceutical company in ... majority-owned subsidiary, Shandong Taibang Biological Products Co. Ltd., ... the China Food and Drug Administration (the "CFDA") ... previously disclosed in the Company,s public filings, the ...
(Date:12/24/2014)... 2014 Sigma-Aldrich Corporation (NASDAQ: ... under the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) ... 22, 2014, thereby completing the U.S. HSR Act ... of the Company by Merck KGaA, Darmstadt, Germany.  ... condition to closing the transaction, which remains subject ...
(Date:12/22/2014)... 22, 2014 The Center for ... of technical training across the life sciences industry, has ... (SCDM) to provide the organization's members with discounted ... access to the more than 350 sessions across 80 ... 10% off when registering for a public course ...
Breaking Biology Technology:Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3
... July 8 Cornerstone Therapeutics Inc. (Nasdaq: ... special meeting of its stockholders on August 27, 2009. ... will be asked to approve a series of amendments ... implement governance arrangements and provide Chiesi Farmaceutici SpA with ...
... SAN DIEGO, July 8 Biomatrica today announced that ... SampleMatrix room temperature storage technology to archive its DNA ... SampleMatrix technology in place of ultra-low-temperature freezers for the ... SMGF will move its collection of previously archived samples ...
... Researchers at Cellular Dynamics ... pluripotent stem cells, which have the ability to generate all ... ordinary human blood samples. This significant breakthrough provides a readily ... samples in storage at blood repositories and healthcare institutions worldwide. ...
Cached Biology Technology:Cornerstone Therapeutics Inc. Announces Record Date and Meeting Date for Special Meeting of Stockholders for Vote with Respect to Charter Amendments 2Cornerstone Therapeutics Inc. Announces Record Date and Meeting Date for Special Meeting of Stockholders for Vote with Respect to Charter Amendments 3Cornerstone Therapeutics Inc. Announces Record Date and Meeting Date for Special Meeting of Stockholders for Vote with Respect to Charter Amendments 4Cornerstone Therapeutics Inc. Announces Record Date and Meeting Date for Special Meeting of Stockholders for Vote with Respect to Charter Amendments 5Sorenson Molecular Genealogy Foundation to Protect Archived DNA Using Biomatrica's Room Temperature Storage 2Sorenson Molecular Genealogy Foundation to Protect Archived DNA Using Biomatrica's Room Temperature Storage 3Cellular Dynamics International Reprograms Blood Cells into Stem Cells 2
Gentamicin sulfate, 5g...
E2F2 protein...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Anti-ACTH Immunogen: Porcine ACTH conjugated to BSA. Available Date: 38566...
Biology Products: