Navigation Links
Ovarian cancer metastases influenced by factors in target tissues
Date:7/17/2013

terine, and mesenteric fat). They found that different ovarian cancer cell lines (mouse derived ID8, and human derived SKOV3ip.1, HeyA8, and CaOV3) specifically colonize omental and splenoportal fat, forming large lesions of cancer cells within milky spots. In contrast, ovarian cancer cells were rarely detected in abdominal fat that lacks milky spots.

The rapid localization of ovarian cancer cells to milky spots indicated that omental tissue secretes a factor, or factors that attract the cancer cells to these structures. Experiments showed that milky-spot-containing tissues in particular can condition cell growth medium to stimulate the migration of cancer cells. This study found that cell medium conditioned by omenta and splenoportal fat caused a 95-fold increase in cell migration, compared to controls. This study also examined mice with specific immunodeficiencies to show that ovarian cancer cell colonization of milky spots is not affected by deficiency or absence of T cells, B cells, and/or NK cells.

The authors also found an inverse relationship between ovarian cancer cell growth and depletion of adipocytes. "These data are consistent with previous reports from other investigators that indicate cancer cells use lipids stored in adipocytes as an energy source for their continued growth," says Dr. Rinker-Schaeffer. "Certain tumor cells (the 'seed') have a proclivity for specific organ microenvironments (the 'soil')," adds Dr. Rinker-Schaeffer. "Pioneers of metastasis research appreciated that the unique tissue architecture, physiology, and function of the target organ are essential to understanding metastatic organ specificity. With this in mind, we hope that our findings and discussion of how they fit into the big picture of omental colonization will facilitate studies that continue to improve our understanding of this process."

In 2012, ovarian cancer was diagnosed in almost 23,000 American women and 16,000 died from the disease.
'/>"/>

Contact: Eileen Leahy
ajpmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
2. Life span of ovarian grafts longer than expected
3. Early menopause: A genetic mouse model of human primary ovarian insufficiency
4. Ovarian tumor, with teeth and a bone fragment inside, found in a Roman-age skeleton
5. Identified as responsible for breast and ovarian hereditary cancer 3 mutations at BRCA1 gene
6. An article in Cell reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
7. Adverse effects of phthalates on ovarian response to IVF
8. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
9. Embryonic development protein active in cancer growth
10. BRG1 mutations confer resistance to hormones in lung cancer
11. Genetic variation in East Asians found to explain resistance to cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... 2015 According to a ... (Hardware, Software, Services), by Applications (Surveillance (Airborne, Maritime, ... End-Users (Military & Defense & Commercial) - Global ... Market is expected to grow from $7252.0 Million ... a Compound Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/19/2015)... May 19, 2015  Technology is rapidly advancing, outpacing ... in the cloud. Passwords and their management are soon ... and standards-based specifications such as those developed by the ... of passwords presents for BYOD, COPE, IoT, and mobile ... identity protocol. In response to the ...
(Date:5/11/2015)... , May 11, 2015  Synaptics Incorporated ... human interface solutions, today announced the appointment of ... and Chief Financial Officer, reporting to Rick ... Synaptics, current Chief Financial Officer, Kathleen Bayless ... Mr. Ali brings extensive financial ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... aquatic organism that is on the state,s most dangerous ... and Coos Bay, and scientists say this "colonial tunicate" ... and environmental implications. Its propensity to foul surfaces ... could make it costly to control, and its ability ...
... Americans to name the most important problem facing ... this time-honored polling question masks the public,s true ... researchers. "For years, the wording used in ... the public has placed on global warming and ...
... that cheese can help preserve and enhance the immune ... for probiotic bacteria. The research, published in FEMS ... of probiotic cheese helps to tackle age-related changes in ... of aged individuals in modern society makes finding innovative ...
Cached Biology News:Invasive 'tunicate' appears in Oregon's coastal waters 2Invasive 'tunicate' appears in Oregon's coastal waters 3Invasive 'tunicate' appears in Oregon's coastal waters 4Opinion polls underestimate Americans' concern about the environment, Stanford study finds 2Opinion polls underestimate Americans' concern about the environment, Stanford study finds 3Cheese found to improve the immune response of the elderly 2
(Date:5/21/2015)... , May 21, 2015 /PRNewswire/ - RepliCel Life ... stage regenerative medicine company focused on the development ... poster presentation at the International Society for Cellular ... chronic Achilles tendinosis currently in a Phase 1/2 ... 29 th from 5:30 PM to 7:00 ...
(Date:5/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/x4b7kw/top_technologies ) has ... HW_Technical Insights" report to their offering. ... in the Health and Wellness sector and has identified ... impact in the year 2015. The research service provides ... and wellness technologies that are anticipated to have the ...
(Date:5/20/2015)... The global genotyping market is expected ... forecast period of 2015 to 2020 to reach $17.0billion ... drug discovery and development process and to provide personalized ... to this,heavy investments by key manufacturers to offer advanced ... market growth. Browse 113 market data tables & 37 ...
(Date:5/20/2015)... BRAINTREE, Mass. , May 20, 2015  Haemonetics ... Brian Concannon , President & CEO, will present at ... New York on June 1 st , ... public may access Mr. Concannon,s presentation live via webcast ... Haemonetics Haemonetics (NYSE: HAE ) is a ...
Breaking Biology Technology:RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Top Technologies in the Health and Wellness Industry 2015 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 4Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 5
... Volcano Corporation,(Nasdaq: VOLC ), a leader ... diagnosis and treatment of coronary and peripheral artery,disease, said ... of,Axsun Technologies, Inc. , Axsun ... optical,engines used in medical Optical Coherence Tomography (OCT) imaging ...
... Performance in Turbulent EconomyOAKBROOK TERRACE, Ill., Jan. 7 ... segments of the high-tech industry, announced today that the ... ILTI ) outperformed the Dow Jones Industrial Average (.INDU), ... inception in 2008.On May 19, 2008, AeA and The ...
... GlaxoSmithKline plc (LSE/NYSE: GSK ) announced today ... wholly-owned subsidiary Gemstone Acquisition Corporation for shares of common ... ). The tender offer expired at 12:00 midnight, New ... for the tender offer has advised GSK that shareholders ...
Cached Biology Technology:Volcano Announces Closing of Axsun Technologies Acquisition 2NASDAQ OMX AeA Illinois Tech Index Outperforms Market 2NASDAQ OMX AeA Illinois Tech Index Outperforms Market 3GlaxoSmithKline Successfully Completes Tender Offer for Shares of Genelabs Technologies, Inc. 2
Cyan Standard is 7-hydroxy-4-trifluoromethylcoumarin...
... volume applications, including pediatric, neonatal, geriatric, general adult, veterinary and experimental animals. Automatic Calibration with 2 ... ... ... ...
X-Gal, 100 mg. 5-Bromo-4-chloro-3-indolyl-b-d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: Nucleotides & Enzy...
Mouse/Rat WNK1 Affinity Purified Polyclonal Ab...
Biology Products: