Navigation Links
Outsmarting cancer cells: SLU scientists learn how they spread

ST. LOUIS Saint Louis University researchers have identified a novel mechanism to control the traffic of cells and fluid from tissues to lymphatic vessels. It may be possible to harness this mechanism to fight cancer spread from one organ to another organ and improve the effectiveness of vaccines.

The lymphatic system is an extensive fluid transit system, consisting of vessels in the body. It defends the body against infection. Cancer cells and infection-fighting cells that are part of the immune system use the lymphatic system to get to other organs, including the lymph nodes.

When cancer cells travel along the lymphatic system from one part of the body to another, they can cause metastases spread to other organs. Many cancer cells, such as those from breast cancer, prostate cancer and lung cancer, enter the lymphatic vessels by releasing molecules that unbutton button-like structures between lymphatic lining cells. This enables them to gain passage into or out of the lymphatic transport system.

SLU scientists have found that molecules known as CRSBP-1 (also termed LYVE-1) ligands, which are a group of growth factors and cytokines, bind to CRSBP-1 receptors, which are located on the surface of lymphatic vessels. This stimulates a response, and acts like a token to gain entry to the lymphatic vessel network. This mechanism for getting into the lymphatic system is used by many cancer cells.

"When the token binds to CRSBP-1, it opens the gate," said Wei-Hsien Hou, Ph.D., lead author of the paper and an M.D./Ph.D. student at Saint Louis University School of Medicine. "Our study is the first to identify a function for this protein. It's important because it gives us a new target to block metastasis, treat edema (swelling of the body from fluid build-up) and enhance the effectiveness of vaccines by strengthening the body's immune responses."

The research team also found that that CRSBP-1 ligand molecules (PDGF-BB and VEGF-A) decrease edema in a mouse model by opening lymphatic intercellular junctions, allowing fluid to drain through the lymphatic network and causing swelling to go down.

Understanding how to gain access into the lymphatic network is significant and will have a strong impact in the fields of cancer and immune research, said Jung S. Huang, Ph.D., a study co-author, professor of biochemistry and molecular biology at Saint Louis University and Hou's mentor. "Once you figure out how breast and other cancers spread, you can begin to work on blocking the process. This is very exciting," he said.


Contact: Nancy Solomon
Saint Louis University

Related biology news :

1. Breast cancer treatment resistance linked to signaling pathway
2. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
3. The dietary supplement genistein can undermine breast cancer treatment
4. Saliva proteins could help detection of oral cancer
5. Vitamin C supplements may reduce benefit from wide range of anti-cancer drugs
6. Breakthrough optical technology to assess colon cancer risk, accuracy
7. Breast cancer cells recycle to escape death by hormonal therapy
8. Nanodiamond drug device could transform cancer treatment
9. Second lumpectomy for breast cancer reduces survival rates
10. Study looks at psychological impact of gene test for breast cancer
11. SNM releases new fact sheet on breast cancer and molecular imaging
Post Your Comments:
(Date:10/29/2015)... 29, 2015  The J. Craig Venter Institute (JCVI) ... Synthesis and Biosecurity: Lessons Learned and Options for the ... and Human Services guidance for synthetic biology providers has ... --> --> Synthetic biology ... potential to pose unique biosecurity threats. It now is ...
(Date:10/29/2015)... 2015 Today, LifeBEAM , a ... 2XU, a global leader in technical performance sports ... with advanced bio-sensing technology. The hat will allow ... key biometrics to improve overall training performance. As ... will bring together the most advanced technology, extensive ...
(Date:10/26/2015)... and LAS VEGAS , Oct. ... Labs , an innovator in modern authentication and a ... announced the launch of its latest version of the ... enabling organizations to use standards-based authentication that supports existing ... S3 Authentication Suite is ideal for organizations deploying customer-facing ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... -- Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will be presenting ... on Wednesday, December 2 at 9:30 a.m. ET/6:30 a.m. ... will provide a corporate overview. th Annual Oppenheimer ... p.m. ET/10:00 a.m. PT . Jim Mazzola , vice ... overview. --> th Annual Oppenheimer Healthcare Conference in ...
(Date:11/24/2015)... ... November 24, 2015 , ... Copper is an essential micronutrient ... to proteins, copper is also toxic to cells. With a $1.3 million award ... will conduct a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. ...
(Date:11/24/2015)... QUEBEC CITY , Nov. 24, 2015 /PRNewswire/ - ... the request of IIROC on behalf of the Toronto ... this news release there are no corporate developments that ... price. --> --> ... --> . --> Aeterna Zentaris ...
(Date:11/24/2015)... 2015 --> ... "Oligonucleotide Synthesis Market by Product & Services (Primer, Probe, ... DNA, RNAi), End-User (Research, Pharmaceutical & Biotech, Diagnostic Labs) ... market is expected to reach USD 1,918.6 Million by ... CAGR of 10.1% during the forecast period. ...
Breaking Biology Technology: