Navigation Links
Our brains make their own marijuana: We're all pot heads deep inside
Date:4/20/2009

U.S. and Brazilian scientists have just proven that one of Bob Dylan's most famous lines"everybody must get stoned" is correct. That's because they've discovered that the brain manufactures proteins that act like marijuana at specific receptors in the brain itself. This discovery, published online in The FASEB Journal (http://www.fasebj.org), may lead to new marijuana-like drugs for managing pain, stimulating appetite, and preventing marijuana abuse.

"Ideally, this development will lead to drugs that bind to and activate the THC receptor, but are devoid of the side effects that limit the usefulness of marijuana," said Lakshmi A. Devi of the Department of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine in New York and one of the senior researchers involved in the study. "It would be helpful to have a drug that activated or blocked the THC receptor, and our findings raise the possibility that this will lead to effective drugs with fewer side effects."

Scientists made their discovery by first extracting several small proteins, called peptides, from the brains of mice and determining their amino acid sequence. The extracted proteins were then compared with another peptide previously known to bind to, but not activate, the receptor (THC) affected by marijuana. Out of the extracted proteins, several not only bound to the brain's THC receptors, but activated them as well.

"The War on Drugs has hit very close to home," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Last year, scientists found that our skin makes its own marijuana-like substance. Now, we see that our brain has been making proteins that act directly on the marijuana receptors in our head. The next step is for scientists to come up with new medicines that eliminate the nasty side of pota better joint, so to speak."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Rice University psychologist finds womens brains recognize, encode smell of male sexual sweat
2. Old and young brains rely on different systems to remember emotional content
3. The satellite navigation in our brains
4. Big brains arose twice in higher primates
5. Brains R Us: Neuroscience and education town hall
6. From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research
7. Doctors learn to control their own brains pain responses to better treat patients
8. Food security for leaf-cutting ants: Workers and their fungus garden reject endophyte invaders
9. Genes that make bacteria make up their minds
10. Children who are dissatisfied with their appearance often have problems with their peer group
11. Female mammals follow their noses to the right mates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed ... received the prestigious international IAIR Award for the most innovative high security ... ... Maldives Immigration Controller General, ... picture on the right) have received the IAIR award for the "Most ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and Markets ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 8.8% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
Breaking Biology News(10 mins):
(Date:5/15/2017)... ... May 15, 2017 , ... Continuing to build off ... has today launched its first-ever cross-medium campaign, #StandFirm, with high-visibility social and digital ... social media channels, emphasizing Algenist’s stance on individuality and disruption: , We ...
(Date:5/12/2017)... ARBOR, Mich. , May 12, 2017 ... selected to present at the 36th annual Michigan Growth ... Forum. GreenMark, a Delaware corporation ... be presenting to investors in attendance, including more than ... deliver health benefits to society through biobased targeting technologies. ...
(Date:5/11/2017)... BioLife Solutions , Inc. (NASDAQ: BLFS ), a ... and tissue hypothermic storage and cryopreservation freeze ... and financial results for the first quarter of 2017. ... high of $2.4 million in the first quarter of 2017, ... Revenue growth was driven by sales of CryoStor ® ...
(Date:5/11/2017)... Yorba Linda, Ca (PRWEB) , ... May 11, ... ... (hPSCs) and primary rodent neurons both are excellent resources for disease modeling and ... culture and further differentiated into mature neurons for various applications, however, these often ...
Breaking Biology Technology: