Mosbach, Germany, April 2, 2012 Biochemist and geneticist Alexander Varshavsky (California Institute of Technology, USA), who was born in Moscow and has lived in the USA since 1977, has been awarded the Otto Warburg Medal of the German Society for Biochemistry and Molecular Biology (GBM). That medal is considered to be the highest German award for biochemists and molecular biologists.
By means of genetic research carried out with yeast and cell cultures of higher organisms, Alexander Varshavsky has made a decisive contribution to discovering the importance of the ubiquitin-dependent intracellular protein degradation, which plays a central role in many regulatory processes such as, for instance, in the cell cycle, in malignant transformation, in the regulation of inflammation, immune response, and many other biological processes.
Elsevier, one of the world-leading providers of scientific, technical and medical information products and services, and its flagship title Biochimica et Biophysica Acta (BBA) are proud to be the exclusive sponsors of the prize money of 25,000 euros.
Alexander Varshavsky was born in Moscow, Russia, where he studied chemistry and obtained his PhD in biochemistry. In 1977 he emigrated to the United States and has worked initially at the Massachusetts Institute of Technology (MIT). In 1992, his laboratory moved to the California Institute of Technology (Caltech) in Pasadena.
The field of ubiquitin and regulated protein degradation was created In the 1980s, with the Varshavsky laboratory discovering the first and major biological functions of the ubiquitin system, the first degradation signals in short-lived proteins, and cloning the first ubiquitin ligases. Ubiquitylation marks proteins for degradation by the 26S proteasome. Specific malfunctions in the ubiquitin system play major roles in many human diseases, including cancer and neurodegeneration syndromes.
|Contact: Dr. Anke Lischeid|