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Ottawa researchers discover new combination therapy to kill cancer
Date:1/27/2014

OTTAWA, ON January 27, 2014 Cancer is the leading cause of death in Canada and is responsible for about 30% of all deaths, according to the Canadian Cancer Society. Despite the urgent need for new and effective drugs, it remains extremely difficult to develop anti-cancer therapies in a timely way. Researchers in Ottawa looked at how to leverage current experimental therapies, in different combinations, to speed the fight against cancer. Scientific evidence suggests a specific combination approach is effective, as published today in Nature Biotechnology.

"We are very excited about this novel combination approach and are looking to move this experimental therapy into clinical trials as soon as possible," said Dr. Robert Korneluk, distinguished professor at the University of Ottawa and senior scientist at the CHEO Research Institute. "I firmly believe that it's not a matter of 'if' this will help cancer patients but 'when' this therapy becomes a standard of care."

Worldwide evidence has already shown that two immunotherapies are promising. The first, SMAC Mimetics, is an IAP-based therapy that targets cancer-causing genes. IAPs were discovered at CHEO 19 years ago. The second, live virus therapies, or oncolytics, are a separate field of study booming in Ottawa. Both of these immunotherapies are in clinical trials now and although the results are encouraging, neither, as a stand-alone therapy, have yet to show substantial effects. That is until a team of scientists led by Dr. Korneluk discovered that combining SMAC Mimetics together with a live virus (or even other non-viral immune stimulators), results in a synergistic, or amplified, tumour-killing effect, which overcomes the limitation of either agent on its own.

"Our combination approach is quite different than standard chemotherapy treatments that can have significant negative side-effects," continued Dr. Korneluk. "Instead, we looked at combining two novel experimental can
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Contact: Adrienne Vienneau
avienneau@cheo.on.ca
613-737-7600 x4144
Children's Hospital of Eastern Ontario Research Institute
Source:Eurekalert

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