Navigation Links
Ottawa researchers discover new combination therapy to kill cancer
Date:1/27/2014

OTTAWA, ON January 27, 2014 Cancer is the leading cause of death in Canada and is responsible for about 30% of all deaths, according to the Canadian Cancer Society. Despite the urgent need for new and effective drugs, it remains extremely difficult to develop anti-cancer therapies in a timely way. Researchers in Ottawa looked at how to leverage current experimental therapies, in different combinations, to speed the fight against cancer. Scientific evidence suggests a specific combination approach is effective, as published today in Nature Biotechnology.

"We are very excited about this novel combination approach and are looking to move this experimental therapy into clinical trials as soon as possible," said Dr. Robert Korneluk, distinguished professor at the University of Ottawa and senior scientist at the CHEO Research Institute. "I firmly believe that it's not a matter of 'if' this will help cancer patients but 'when' this therapy becomes a standard of care."

Worldwide evidence has already shown that two immunotherapies are promising. The first, SMAC Mimetics, is an IAP-based therapy that targets cancer-causing genes. IAPs were discovered at CHEO 19 years ago. The second, live virus therapies, or oncolytics, are a separate field of study booming in Ottawa. Both of these immunotherapies are in clinical trials now and although the results are encouraging, neither, as a stand-alone therapy, have yet to show substantial effects. That is until a team of scientists led by Dr. Korneluk discovered that combining SMAC Mimetics together with a live virus (or even other non-viral immune stimulators), results in a synergistic, or amplified, tumour-killing effect, which overcomes the limitation of either agent on its own.

"Our combination approach is quite different than standard chemotherapy treatments that can have significant negative side-effects," continued Dr. Korneluk. "Instead, we looked at combining two novel experimental can
'/>"/>

Contact: Adrienne Vienneau
avienneau@cheo.on.ca
613-737-7600 x4144
Children's Hospital of Eastern Ontario Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
2. Cleveland Clinic researchers discover process that turns good cholesterol bad
3. Researchers discover potential drug targets for early onset glaucoma
4. Researchers identify innate channel that protects against pain
5. Combustion continues to draw researchers to space station
6. Curtin researchers to hide our splashes from sharks
7. Researchers discover how heart arrhythmia occurs
8. Researchers collaborate to reduce effects of the aging eye
9. 1 step at a time, researchers learning how humans walk
10. Researchers discover that coevolution between humans and bacteria reduces gastric cancer risk
11. Researchers identify key components linking circadian rhythms and cell division cycles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... has different effects on different species of fish, ... of Bristol and Exeter which tested fish anti-predator ... a flying seagull predator model when exposed to ... European minnows. , Lead author Dr Irene ... "Noise levels in many aquatic environments have increased ...
(Date:7/24/2014)... smog-free Los Angeles, where electric cars ply silent freeways, ... heat from beneath the earth, from howling winds and ... study finds that it is technically and economically feasible ... by clean, renewable energy. Published in Energy , ... and reliable energy supply in California that could create ...
(Date:7/24/2014)... sticky research out of York University shows a surprisingly ... toxic grass fungus: moose saliva (yes moose saliva). ... "Ungulate saliva inhibits a grassendophyte mutualism" shows that moose ... (which hosts a fungus called epichlo festucae that produces ... less toxicity. , "Plants have evolved defense mechanisms to ...
Breaking Biology News(10 mins):Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4Moose drool inhibits growth of toxic fungus: York U research 2
... a cold or flu knows, a high temperature is ... immune reaction when fighting off pathogens. Laboratory studies, in ... in detail, have shown that these responses display significant ... the maximum possible level of intensity? New immunological theories ...
... about positive and negative emotions they often use spatial metaphors. A ... person is down in the dumps. Some researchers believe these metaphors ... do we use spatial words to talk about emotional states, we ... and emotion To test this link between vertical space ...
... two license agreements with SuperPower, a wholly-owned subsidiary ... intellectual property on second generation (2G) high temperature ... Sponsored Research Agreement (SRA) previously executed between the ... by Venkat Selvamanickam, M.D. Anderson chair professor of ...
Cached Biology News:Only some like it hot 2To remember the good times, reach for the sky 2SuperPower and UH sign high temperature superconducting wire license agreements 2
(Date:7/25/2014)... new study by researchers from the University of ... nanosystems function, unlocking the potential to create new ... which has been published in the prestigious academic ... novel laser technique to examine in rich detail ... small cluster containing an acetylene molecule and a ...
(Date:7/25/2014)... Diego, CA (PRWEB) July 25, 2014 WABC ... For Your Pet with Lorry Young will be hosting ... to talk about stem cell therapy in pets. Dr. ... the benefits of stem cell therapy for pets suffering from ... moving the Regenerative Veterinary Medicine industry forward. , Young has ...
(Date:7/25/2014)... , July 25, 2014  Galmed Pharmaceuticals Ltd. (Nasdaq: ... focused on the development and commercialization of a once-daily, ... cholesterol gallstones, today announced financial results for the period ... Financial Summary: , Reported cash and cash equivalents ... $137,000 at December 31, 2013.  , Reported a ...
(Date:7/25/2014)... 25, 2014 Sinovac Biotech Ltd. (Nasdaq: ... China , today announced that it will release ... 30, 2014, after market close on Thursday, August 14, 2014 ... the market opening on Friday, August 15, 2014, at 8:00 ... Standard Time) to review the Company,s financial results and provide ...
Breaking Biology Technology:Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2
... company that provides a smart federated data integration architecture. ( ... Manager Eric Westra that the new name for the company ... ) Imagis was the first of some dozen or so ... Columbia, and in some ways it is the odd-one-out. Vancouver ...
... Wis. - A proposed state ban on all ... Assembly Committee on Children and Families and is headed for ... on a fast track with identical bills - SB 243 ... The legislation has drawn vigorous opposition from both the scientific ...
... Thursday that Joe Hogan, head of GE Healthcare Technologies in ... in London next year as part of the parent ... ,Hogan will succeed Bill Castell as head of GE Healthcare ... of the Waukesha-based GE Healthcare Technologies division since 2000, when ...
Cached Biology Technology:Fleet management vendors capitalize on wireless 2Fleet management vendors capitalize on wireless 3Fleet management vendors capitalize on wireless 4Cloning ban too broad, stem-cell researchers argue 2Cloning ban too broad, stem-cell researchers argue 3Cloning ban too broad, stem-cell researchers argue 4
...
Recombinant Rat Leptin, CF...
Adhesive seal-tab, for HybriWell™ hybridization sealing system *set of 400*...
... culture systems provide an integrated set-up ... and imaging. Each system uses medical-grade ... coverslips in cell culture plates. The ... ready to use. Individual chambered coverslips ...
Biology Products: