Navigation Links
Ottawa researchers discover new combination therapy to kill cancer
Date:1/27/2014

OTTAWA, ON January 27, 2014 Cancer is the leading cause of death in Canada and is responsible for about 30% of all deaths, according to the Canadian Cancer Society. Despite the urgent need for new and effective drugs, it remains extremely difficult to develop anti-cancer therapies in a timely way. Researchers in Ottawa looked at how to leverage current experimental therapies, in different combinations, to speed the fight against cancer. Scientific evidence suggests a specific combination approach is effective, as published today in Nature Biotechnology.

"We are very excited about this novel combination approach and are looking to move this experimental therapy into clinical trials as soon as possible," said Dr. Robert Korneluk, distinguished professor at the University of Ottawa and senior scientist at the CHEO Research Institute. "I firmly believe that it's not a matter of 'if' this will help cancer patients but 'when' this therapy becomes a standard of care."

Worldwide evidence has already shown that two immunotherapies are promising. The first, SMAC Mimetics, is an IAP-based therapy that targets cancer-causing genes. IAPs were discovered at CHEO 19 years ago. The second, live virus therapies, or oncolytics, are a separate field of study booming in Ottawa. Both of these immunotherapies are in clinical trials now and although the results are encouraging, neither, as a stand-alone therapy, have yet to show substantial effects. That is until a team of scientists led by Dr. Korneluk discovered that combining SMAC Mimetics together with a live virus (or even other non-viral immune stimulators), results in a synergistic, or amplified, tumour-killing effect, which overcomes the limitation of either agent on its own.

"Our combination approach is quite different than standard chemotherapy treatments that can have significant negative side-effects," continued Dr. Korneluk. "Instead, we looked at combining two novel experimental cancer drugs that we already know work on the immune system. The results of our combination exceeded expectations and furthermore, no harm was done to the surrounding healthy tissue when we eradicated tumours."

In some cases, tumours required 10,000-times less virus to kill a cancer cell when a SMAC mimetic was added. The combined use of these two drugs could possibly save years of clinical development time, allowing for faster patient access to these drugs. The research team postulates that this combination approach is likely better suited for specific cancers and specific uses. For example, tumours which cannot be surgically removed but which can be injected with a cancer-killing virus are good candidates.


'/>"/>

Contact: Adrienne Vienneau
avienneau@cheo.on.ca
613-737-7600 x4144
Children's Hospital of Eastern Ontario Research Institute
Source:Eurekalert

Related biology news :

1. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
2. Cleveland Clinic researchers discover process that turns good cholesterol bad
3. Researchers discover potential drug targets for early onset glaucoma
4. Researchers identify innate channel that protects against pain
5. Combustion continues to draw researchers to space station
6. Curtin researchers to hide our splashes from sharks
7. Researchers discover how heart arrhythmia occurs
8. Researchers collaborate to reduce effects of the aging eye
9. 1 step at a time, researchers learning how humans walk
10. Researchers discover that coevolution between humans and bacteria reduces gastric cancer risk
11. Researchers identify key components linking circadian rhythms and cell division cycles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
(Date:3/29/2016)... March 29, 2016 LegacyXChange, Inc. ... "LEGX" and SelectaDNA/CSI Protect are pleased to announce our ... in a variety of writing instruments, ensuring athletes signatures ... created collectibles from athletes on LegacyXChange will be assured ... the DNA. Bill Bollander , CEO ...
Breaking Biology News(10 mins):
(Date:5/6/2016)... Recent studies show that patients no longer ... when treating certain types of pain. With the past ... go right to the source instead of masking the ... provides physician training about the benefits of regenerative adult ... physicians across the United States ...
(Date:5/5/2016)... , May 5, 2016  Why are two uber-successful ... Lorna Weir launching a new venture—yet going ... they believe that truly helping clients raise the value ... now demands a different type of collaboration. ... the pharmaceutical, biotechnology and medical device sectors. Elevate specializes ...
(Date:5/4/2016)... 4, 2016  Bayer today announced that a ... ® (regorafenib) tablets for the treatment of ... its primary endpoint of a statistically significant improvement ... the efficacy and safety of regorafenib in patients ... with sorafenib. The safety and tolerability were generally ...
(Date:5/3/2016)... , May 3, 2016 ... Chip (Genomics, Drug Discovery, Gene Expression) Lab-on-a-chip ... user (Academics Institutes, Diagnostics Centers), Fabrication Technology ... by MarketsandMarkets, the market is expected to ... USD 7.63 Billion in 2015, growing at ...
Breaking Biology Technology: