Navigation Links
Osteoarthritis medicine delivered on-demand
Date:11/6/2013

Scientists are reporting development of a squishy gel that when compressed like at a painful knee joint releases anti-inflammatory medicine. The new material could someday deliver medications when and where osteoarthritis patients need it most. Their study appears in the ACS journal Biomacromolecules.

Xinqiao Jia, Chandran R. Sabanayagam and colleagues note that in the past few decades, researchers have been developing a variety of "smart" hydrogels that can release medications over several days rather than in a single burst. Most of these gels release medicine all the time or in response to changes in temperature, light or other factors. Very few respond to physical pressure, which is what causes pain in the 27 million osteoarthritis patients in the U.S. Osteoarthritis is called the "wear-and-tear" type of arthritis. The cartilage between the bones becomes damaged and wears away, making everyday movements of the knees, hands, backs and hips severely painful. Jia and Sabanayagam set out to develop an on-demand, drug-delivery system for pain management and tissue repair in a way that makes more sense for osteoarthritis patients.

They created a special type of hydrogel that responds to compression such as the pressure between joints that occurs in everyday movement and loaded it with an anti-inflammatory drug called dexamethasone, which is sometimes used to treat arthritis. When they compressed the hydrogel in the laboratory, it boosted the release of the drug. The researchers are currently testing their smart pain medications in laboratory animals.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Worlds largest meeting dedicated to osteoporosis and osteoarthritis opens in Rome
2. Less than 1 month to start of European Congress on Osteoporosis & Osteoarthritis in Rome
3. Yale Study links common chemicals to osteoarthritis
4. European Congress on Osteoporosis and Osteoarthritis
5. Lack of vitamin D contributes to pain in black Americans with knee osteoarthritis
6. UIC study examines exercise and weight loss for older adults with osteoarthritis
7. Scientists discover an epigenetic cause of osteoarthritis
8. College of Veterinary Medicine researcher doubles down on deadly, infectious cat diseases
9. Ludwig scientist Richard D. Kolodner elected to the Institute of Medicine
10. Leader of smoking cessation and tobacco prevention efforts receives Institute of Medicines 2013 Lienhard Award
11. Institute of Medicine Elects 70 New Members, 10 Foreign Associates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016  Global demand for enzymes ... through 2020 to $7.2 billion.  This market includes ... cleaning products, biofuel production, animal feed, and other ... and biocatalysts). Food and beverages will remain the ... increasing consumption of products containing enzymes in developing ...
(Date:6/27/2016)... CA (PRWEB) , ... June 27, 2016 , ... ... for clinical trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT ... care circle with the physician and clinical trial team. , Using the CONSULT module, ...
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
Breaking Biology Technology: