Navigation Links
Origins of XMRV deciphered, undermining claims for a role in human disease
Date:5/31/2011

Delineation of the origin of the retrovirus known as XMRV from the genomes of laboratory mice indicates that the virus is unlikely to be responsible for either prostate cancer or chronic fatigue syndrome in humans, as has been widely published. The virus arose because of genetic recombination of two mouse viruses. Subsequent infection of lab experiments with XMRV formed the basis of the original association.

Reporting in Science, Vinay Pathak, Ph.D., and his research team from the National Cancer Institute (NCI), part of the National Institutes of Health, in collaboration with other researchers, described experiments that provide an understanding of when and how XMRV arose and explain the original, incorrect association. XMRV stands for xenotropic murine leukemia virusrelated virus.

This study is being reported in the same issue of Science as another study of XMRV (Knox et al.) that finds a lack of association between the virus and CFS even in the same patients from a 2009 study. "Taken together, these results essentially close the door on XMRV as a cause of human disease," said John Coffin, Ph.D., special advisor to the NCI director, and professor at Tufts University School of Medicine, a coauthor of the paper with Pathak.

Murine leukemia viruses are retroviruses that cause cancers and other diseases in mice. They are divided into different classes, one of which is xenotropic murine leukemia viruses. Although viruses in this class cannot grow in or infect cells from most mice, in the laboratory they can infect cells from other species, including human cells.

XMRV was first reported in samples from a human prostate tumor in 2006, and has been reported to be present in 6 percent to 27 percent of human prostate cancers. Later research reported XMRV in the blood of 67 percent of people with CFS.

The assertion that XMRV is circulating in the human population has been challenged by several studies t
'/>"/>

Contact: NCI Office of Media Relations
NCIPressOfficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Origins of wolverine in California genetically verified
2. Researchers to reveal agings origins on global stage
3. Ancient oceans offer new insight into the origins of animal life
4. U of T led research team uncovers evolutionary origins of prion disease gene
5. Extreme genes shed light on origins of photosynthesis
6. U. of Colorado scientists create tiny RNA molecule with big implications for lifes origins
7. Exploring Echinaceas enigmatic origins
8. Scientists at UCSB discover 600-million-year-old origins of vision
9. Molecular study could push back angiosperm origins
10. Educational historian looks at origins of the culture wars
11. Scientists clarify origins of potato germplasm Neo-Tuberosum
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Origins of XMRV deciphered, undermining claims for a role in human disease
(Date:9/30/2014)... 2014  Spectra Automation, a trusted supplier ... and power generation industries, announced today the ... an easy-to-use and cost-effective data collection, analysis ... laboratories. Most upstream process ... systems. Accessing and consolidating data from these ...
(Date:9/29/2014)... Clostridium ramosum , coupled with a high-fat diet, may ... week in mBio , the online open-access journal of ... from the German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal ... ramosum gained weight when fed a high-fat diet. Mice ... obese even when consuming a high-fat diet, and mice that ...
(Date:9/29/2014)... "human activities in this area of the world have contributed ... grown for use as a cooking oil and biofuel, while ... the most widely produced edible oil in the world, and ... soybean oil. , The environmental effects of such growth have ... crop, and the preferred method is fire. The clearing often ...
Breaking Biology News(10 mins):Spectra Automation Introduces RECONN Bioprocess Manager 2Gut bacteria promote obesity in mice 2
... food meal is never good for you, but washing that ... a new University of Guelph study. Researcher Marie-Soleil Beaudoin ... levels spike after eating a high-fat meal, but that the ... coffee jumping to levels similar to those of people ...
... leaves influence the sunlight reaching inner canopy leaves by changing ... physiology of leaves within the tree canopy is not constant, ... crown. This phenomenon is expected to have important consequences for ... A new study describes how the leaves in the outer ...
... ARBOR, Mich.Getting older doesn,t mean giving up muscle strength. ... loss that comes with age, but the Golden Years can be ... Michigan Health System. "Resistance exercise is a great ... people can function more readily in daily life," says Mark Peterson, ...
Cached Biology News:Got a craving for fast food? Skip the coffee, study says 2Older and stronger: Progressive resistance training can build muscle, increase strength as we age 2Older and stronger: Progressive resistance training can build muscle, increase strength as we age 3Older and stronger: Progressive resistance training can build muscle, increase strength as we age 4
(Date:10/1/2014)... Slone Partners , a national ... and Laboratory Testing industries, reported a 120% increase in ... level and above from July 2013 to July 2014. ... of rapid breakthroughs in diagnostics, reimbursement has failed to ... been forced to fold, consolidate, or carry on without ...
(Date:10/1/2014)... Industry leaders from retail ... around the theme, ,Commercial Opportunities in the Era of ... Elsevier , a world-leading provider of scientific, ... a gathering of some of the industry,s most prominent ... today and in the future. The Elsevier ...
(Date:9/30/2014)... Using a bio-mimicking analog of one of nature,s ... international research team led by Alejandro Briseno of ... major step in developing long-sought polymer architecture to ... use in electronic devices. , Briseno, with ... others at Stanford University and Dresden University of ...
(Date:9/30/2014)... , Sept. 30, 2014 Nematicide ... kill nematodes. Nematodes are microscopic parasitic roundworms, found ... and inside other plants and animals. Nematicides have ... or other properties promoting migration through the soil. ... than 1,000 plant-parasitic nematodes. With more than 10,000 ...
Breaking Biology Technology:Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2
... Tetrahedral dice, which have four triangular sides, pack ... to research performed by a collaboration of New York ... result of a series of experiments that involved pouring ... dice until the containers were completely filled. After adding ...
... 3 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals, Inc. ( ANPI, TSX: ANP), a specialty ... exclusive distribution agreement with B. Braun for its proprietary Quill(TM) SRS product line ... The term of the distribution agreement will be for five years. , ... According to The Royal College of Surgeons ...
... , LAWRENCEVILLE, N.J. , May 3 ... (n = 520) multi-center patient registry study of its Lacrisert® ... index (OSDI) in patients with moderate-to-severe dry eye after one ... poster this week during the 2010 Annual Meeting of the ...
Cached Biology Technology:Densest dice packing and computing with molecules 2Angiotech announces exclusive distribution agreement with B. Braun for Angiotech's proprietary Quill(TM) SRS product line 2Angiotech announces exclusive distribution agreement with B. Braun for Angiotech's proprietary Quill(TM) SRS product line 3Angiotech announces exclusive distribution agreement with B. Braun for Angiotech's proprietary Quill(TM) SRS product line 4Angiotech announces exclusive distribution agreement with B. Braun for Angiotech's proprietary Quill(TM) SRS product line 5Study of Lacrisert(R) Dry Eye Insert 2Study of Lacrisert(R) Dry Eye Insert 3Study of Lacrisert(R) Dry Eye Insert 4Study of Lacrisert(R) Dry Eye Insert 5
... scale kinase profiling, quantitative measurement of ... research built on the flexible and ... These microarrays are available as part ... - Peptide Microarray Service. ...
... acid synthetic peptide whose sequences are derived from mouse resistin protein. ... S(21) - S - M - P - L - C ... I - D - K - K - I - K ... be used for neutralization and control experiments with the polyclonal antibody ...
... peptidomimetics built on the flexible and ... These microarrays are available as part ... Service. Custom Probe Content ... specified. Thousands of customer specified peptide ...
... These extended-length microarrays are custom designed to ... configurations are available: 8,455 features per array ... 22,575 features per array (1 array/slide). ... probe length - This extended length ...
Biology Products: