Navigation Links
Origin of cells for connective tissues of skull and face challenged
Date:5/23/2008

With improved resolution, tissue-specific molecular markers and precise timing, University of Oregon biologist James A. Weston and colleagues have possibly overturned a long-standing assumption about the origin of embryonic cells that give rise to connective and skeletal tissues that form the base of the skull and facial structures in back-boned creatures from fish to humans.

Weston and co-authors from the Max Planck Institute of Immunology in Germany and the French National Scientific Research Centre at the Curie Institute document their potentially textbook-changing case in an article appearing online this week (May 19-23) ahead of regular publication in the Proceedings of the National Academy of Sciences.

The cells in question, they argue, do not come from a portion of embryonic neural epithelium called the neural crest, as widely believed, but rather from a distinct thin layer of epidermal epithelial cells next to it. "Our results," Weston said, "could lead to a better understanding of the etiology of craniofacial defects, as well as the evolution of the head that distinguishes vertebrates from other creatures."

The neural crest was first identified by classical embryologists in the late 19th and early 20th centuries and has been one of the most studied embryonic tissues. Conventional wisdom says that the neural crest gives rise to skeletal and connective tissue of the head and face, as well as a wide diversity of other stem cells that migrate to many places in the vertebrate embryo, where they spawn the cells that create the peripheral nervous system, and pigment cells in skin and hair (or scales and feathers).

The new study is part of research done over 25 years in Weston's quest to understand early development of the neural crest and explore alternative explanations for sometimes differing findings involving its assumed cell lineages. Weston noted that mutations in mice that adversely affected development of the periph
'/>"/>

Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Plague of kangaroos threatens one of Australias last remaining original native grasslands
2. The cooperative view: New evidence suggests a symbiogenetic origin for the centrosome
3. Freshwater herring had salty origin
4. Clues to ancestral origin of placenta emerge in Stanford study
5. Researchers close in on origins of main ingredient of Alzheimers plaques
6. Technique traces origins of disease genes in mixed human populations
7. Experts prove the geochemical origin of part of the CO2 emissions in semiarid climates
8. Fungi can tell us about the origin of sex chromosomes
9. Study shows Darwin was wrong about the origins of chickens
10. Darwin was wrong about the wild origin of the chicken
11. ASU researcher may have discovered key to life before its origin on Earth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Biologically Inspired Engineering at Harvard University today announced ... by a newly formed private company to accelerate ... products. The announcement follows a worldwide ... (OTD) and the start-up Emulate Inc., relating to ... platform. , "This is a big win ...
(Date:7/27/2014)... largest prevalence studies to date, researchers from the U.K. ... the hepatitis C virus (HCV). Findings published in Hepatology, ... of Liver Diseases, indicate that genotype 1 is the ... of which one-third reside in East Asia. Genotype 3, ... most prevalent, followed by genotypes 2, 4, 6, and ...
(Date:7/27/2014)... single computer cannot always find the solution a user ... cluster of computers that analyze a massive data set ... history to present you with targeted ads, and how ... movie. But big data is about more than just ... are generating unprecedented quantities of information. That data may ...
Breaking Biology News(10 mins):Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 2Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 3Hepatitis C virus genotype 1 is most prevalent worldwide 2New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5
... San Diego have identified a potential red tide killer. ... accumulate rapidly in dense concentrations have been on the ... dollars in worldwide losses to fisheries and beach tourism ... referred to as harmful algal blooms, remain unpredictable in ...
... Using classroom, hands-on activities can help instructors to ... Despite its importance, the diversity in soil microbes ... natural resource classrooms composed primarily of undergraduates who ... the candy comes into play. , Stephanie ...
... at City of Hope and the California Department of ... detect botulinum neurotoxin. The toxin is one of the ... and is considered a major potential bioterrorism threat agent. ... the online journal PLoS ONE ( http://www.plosone.org/doi/pone.0002041 ). ...
Cached Biology News:Scripps Oceanography Research pegs ID of red tide killer 2Scripps Oceanography Research pegs ID of red tide killer 3The sweet world of soil microbiology 2Researchers develop new ultrasensitive assay to detect most poisonous substance known 2
(Date:7/28/2014)... 28, 2014  David Hardison, Ph.D., vice president ... , has been elected chairman of the board ... non-profit working to establish common protocols around the ... relates to electronic health records. ... collaborating with organizations across the research and health ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 Appistry, ... services that bring the power of genomics to next-generation ... Appistry Pipeline Challenge . , Two Appistry ... of the National Center for Genome Resources, and Mr. ... and Clinics of Kansas City. Rounding out the panel ...
(Date:7/28/2014)... -- InterMune, Inc. (NASDAQ: ITMN ) today announced ... results at the close of the U.S. markets on ... will be hosted by InterMune at 4:30 p.m. Eastern ... others may participate in the conference call by dialing ... of the webcast and teleconference will be available on ...
(Date:7/28/2014)... The National Model Aviation Museum, located ... pleased to announce that it has been granted full ... United States Air Force. , The certification is the ... this spring with an on-site inspection by Sarah Sessions, ... The National Museum of the United States Air ...
Breaking Biology Technology:ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2InterMune to Release Second Quarter Financial Results on August 6 2AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2
... FRANCISCO, March 7, 2012  More than 1,100 leaders from ... Francisco for the two-day conference CALBIO2012: Driven by Patients ... patient access to new treatments through partnering and collaborative ... BIOCOM are organizing a statewide meeting for California,s life ...
... Palatin Technologies, Inc. (NYSE Amex: PTN ) ... ROTH OC Growth Stock Conference on Tuesday, March 13, 2012, ... at the Ritz Carlton Laguna Niguel in Dana Point, CA. ... Officer of Palatin Technologies, will provide an update on Palatin,s ...
...  Synthetic Biologics, Inc.  (NYSE Amex: SYN ), ... medicines for serious illnesses, announced today that Jeff Riley, ... ROTH Capital Partners 24th Annual Growth Stock Conference. The ... Ritz Carlton in Dana Point, CA. Mr. Riley will ...
Cached Biology Technology:First Statewide Biotech Meeting Focuses on Patient Access, Innovation 2Synthetic Biologics to Present at ROTH Annual Growth Stock Conference 2
... MULTI-FUN Incubator is a compact ... uses a microprocessor controller with a ... temperature and agitation speed. Air circulation ... the incubator. Temperature can be easily ...
... of 3 siRNAs specifically targeted to your ... product. The siTrio reagent guarantees you get ... gene when used under standard conditions (100 ... optimal transfection with one of B-Bridges controls). ...
... 96 x 0.2 ml reaction module is ... It is equipped with an interchangeable 96-well ... compatible with optical modules for real-time PCR ... algorithm, block, or in-sample probe. It includes ...
... MULTI-FUN Incubator is a compact ... uses a microprocessor controller with a ... temperature and agitation speed. Air circulation ... the incubator. Temperature can be easily ...
Biology Products: