Navigation Links
Optical technique reveals unnexpected complexity in mammalian olfactory coding
Date:10/18/2010

The algal gene expresses a photoreceptor protein called channelrhodopsin-2 (ChR2).

"We did this, when I was still at Harvard, in Venki Murthy's group, to overcome a problem that has limited olfactory circuit measurement in the past," says Florin Albeanu, Ph.D., a newly appointed assistant professor at CSHL who co-led the investigation. "Previously, we would have tried to insert electrodes into the olfactory bulb of the mouse. This is a bit like flying blind -- you can record the electrical activity of any cells you happen to hit, but you had no way of controlling which cells you would be recording from. Ashesh Dhawale, whom I met at a CSHL course on advanced imaging methods three years ago, and I decided to use light stimulation of the sensory neurons coupled with electrical recordings from the output neurons of the bulb to solve this problem."

The cells Albeanu, Dhawale and colleagues wanted to monitor are called mitral cells. These specialized cells are the final "broadcasting" stations for messages to the mouse's cortex that start out when neurons in the nasal epithelium sense an odor. Each sensory neuron is specialized to express a single molecular odor receptor type, from among some 1500 in a mouse's olfactory palette. Cells with the same sensitivity report their signals to a single specialized spherical unit -- literally a ball of synapses -- in the mouse's olfactory bulb. These collecting stations are called glomeruli.

The glomeruli each have about 15,000 axons feeding into them, and each, in turn, signals via primary dendrites to mitral cells. One glomerulus may be connected to as many as 30 mitral cells, all of which are also located in the olfactory bulb. Mitral cells also sport secondary dendrites, fibers which connect them laterally with one another via reciprocal synapses that link them to inhibitory local interneurons. By directly activating glomeruli in the olfactory bulb with tiny beams of light, the team was ab
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Breakthrough optical technology to assess colon cancer risk, accuracy
2. Femtomolar optical tweezers may enable sensitive blood tests
3. Strained quantum dots show new optical properties
4. Frost & Sullivan Recognizes MIRTEC With the 2009 Award for Automated Optical Inspection Product Innovation of the Year
5. Optical Legos: Building nanoshell structures
6. Applied physicists create building blocks for a new class of optical circuits
7. Optical imaging technique for angioplasty
8. NJIT professor finds engineering technique to identify disease-causing genes
9. New technique enables assessment of drought performance
10. New technique eliminates toxic drugs in islet transplant in diabetic mice
11. These shells dont clam up: Innovative technique to record human impact on coastal waters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... According to a new market ... Systems Market Global Forecast, Market Share, Size, Growth and ... Control systems market was valued at USD 15,406.1 million ... CAGR of 12.6% from 2014 to 2019, to reach ... Browse the full Electronic Access Control Systems ...
(Date:7/10/2014)...  Acuity Market Intelligence today released forecasts from "The Global ... the global market for National Electronic ID (eID) programs will ... this time, the number of National eID cards in circulation ... Asia , with its vast population, will dominate the ... while Europe trails a distant second ...
(Date:7/10/2014)... belongs to the large, mainly tropical flowering plant family ... in the family rely on bees for their pollination. Only ... or vertebrates. The flowers of Axinaea appear in ... petals of the different species are pink, yellow, orange or ... the contrasting colours of their bulbous appendages. The pollination mechanism ...
Breaking Biology News(10 mins):Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2Novel type of bird pollination mechanism discovered in South America 2
... plants do not haphazardly flail about looking for a ... and identify potential hosts by their emissions, according to ... are interested in how plants respond to their environment, ... Consuelo M. De Moraes, assistant professor of entomology. ...
... a key enzyme responsible for triggering a chain of ... study findings published online this week in Nature Immunology. ... the Hospital for Special Surgery and Weill Cornell Medical ... of new strategies and target therapies that control allergic ...
... led by scientists at the Broad Institute of MIT and ... genetic "roadmap" that can connect human diseases with potential drugs ... work in human cells. Called the "Connectivity Map," the new ... issue of Science and in separate publications in the September ...
Cached Biology News:Parasitic plants sniff out hosts 2Parasitic plants sniff out hosts 3Key molecular signaling switch involved in allergic disease identified 2Genetic 'roadmap' charts links between drugs and human disease 2Genetic 'roadmap' charts links between drugs and human disease 3
(Date:7/11/2014)... EPFL and the University of  Geneva ... John P. Donoghue . The American neuroscientist is ... . The new Wyss Center for Bio- ... Geneva , has named as its director one ... Donoghue , founder of Brown University,s Institute for Brain ...
(Date:7/10/2014)... Women in the West African ... additional family planning option. Sayana® Press has the ... levels of the health system and in communities ... used contraceptive—Pfizer’s Depo-Provera® (depot medroxyprogesterone acetate)—with the BD ... first of four African countries expected to begin ...
(Date:7/10/2014)... 2014 Terascala, the industry leader in ... Swahn, a former vice president of product management for ... president of marketing. Terascala’s software when combined with leading ... the highest performance and most reliable solutions for processing ... Terascala’s channel expansion and broaden its product portfolio. His ...
(Date:7/10/2014)... Montreal, QC (PRWEB) July 10, 2014 ... comfort and convenience. This rejuvenating device now comes with a ... that develops over time. , The new cup is thinner ... This design works to target rough, thin and uneven surfaces ... original firm cup for a stimulating treatment on areas such ...
Breaking Biology Technology:John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Terascala Expands Executive Team 2Terascala Expands Executive Team 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2
... , Produce large quantities of difficult-to-express ... Becker ,Biochemical & Molecular Allergology, Research Center ... cells * with,extra copies of E. coli, ... possible to attain high-level expression of difficult ...
... allows for better control of PCR reactions ... Capodanno ,Michael Rahilly ,Stratagene , Stratagenes RoboCycler ... results in every well. The RoboCycler systems unique,design ... optimized for block,temperature uniformity. In this study, fluid ...
... Allelic discrimination kits with excellent specificity, sensitivity, and,assay ... Lingyu Chen ,Stratagene , Because of their unique ... differences, making them ideal for mutation detection and,allelic ... developed a,series of Mx4000 molecular beacon allelic discrimination ...
Cached Biology Technology:High-Level Expression of Peanut Allergens Affected by Rare Codon Usage 2High-Level Expression of Peanut Allergens Affected by Rare Codon Usage 3High-Level Expression of Peanut Allergens Affected by Rare Codon Usage 4Effects of Thermal Cycler Well-To-Well Temperature Uniformity on PCR Results 2Effects of Thermal Cycler Well-To-Well Temperature Uniformity on PCR Results 3Effects of Thermal Cycler Well-To-Well Temperature Uniformity on PCR Results 4Effects of Thermal Cycler Well-To-Well Temperature Uniformity on PCR Results 5Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 2Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 3Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 4Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 5Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 6Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon,Allelic Discrimination Kits 7
Request Info...
... include: ,ICC and IHC Protocol Development ... ,Antibody Screenings in Animal or Human ... of Cells and Tissues ,Peroxidase, Alkaline ... Fluorescent, or Electron Microscopy ,Protein Localization ...
Request Info...
Request Info...
Biology Products: