Navigation Links
OptiNose's novel intranasal sumatriptan product highly effective in treating migraines
Date:4/7/2010

Oslo, April 7, 2010: OptiNose, a leader in nasal drug delivery systems, is pleased to announce the publication in Cephalalgia of results from its Phase II clinical study investigating the efficacy and tolerability of its novel, intranasal drug/device product for the treatment of migraine.

Sumatriptan powder in 10mg and 20mg doses administered intranasally using OptiNose's bi-directional delivery device was highly effective in treating a single attack of moderate or severe migraine. The proportion of patients pain-free at two hours was 54% for the 10 mg dose, 57% for 20 mg and 25% for placebo (P< .05). These results compare very favorably with published figures of 26-42% for liquid sumatriptan nasal spray and 35.6% for zolmitriptan nasal spray and higher than the 28% /29% reported for oral triptans. In addition to high efficacy, OptiNose's bi-directional powder delivery eliminates drip-out and reduces the bitter taste associated with conventional nasal triptan products.

The proportion of subjects with relief of headache post-dose was significantly greater than placebo at 60 minutes (10 mg 73% vs. 38%, P< .01; 20 mg 74% vs. 38%, P< .01), 90 minutes (10 mg 78% vs. 41%, P< .01; 20 mg 77% vs. 41%, P< .01) and 120 minutes (10 mg 84% vs. 44%, P< .001; 20 mg 80% vs. 44%, P< .01). The onset of pain relief was much quicker than conventional orally and nasally delivered triptans and similar to subcutaneous injection of sumatriptan despite much lower systemic exposure. Sustained pain-freedom at 48 hours was also high for both doses (10 mg 47%, 20 mg 49%, P < .05). Treatment-related adverse events were rare.

"The World Health Organization places migraine amongst the top 20 of disabling disorders from a global perspective," says Fred Sheftell, M.D., founder and director of the New England Center for Headache in Stamford, CT. "Novel delivery systems that deliver rapid and sustained pain relief with minimal side effects are needed. The resul
'/>"/>

Contact: Helena Djupesland
Helena.Djupesland@optinose.no
01-147-229-58017
WFD Ventures
Source:Eurekalert

Page: 1 2

Related biology news :

1. UMMS researchers uncover novel genetic pathway responsible for triggering vascular growth
2. Novel Parkinsons treatment strategy involves cell transplantation
3. New University of Colorado paper shows novel way to study human inflammatory disease
4. Novel antitoxin strategy developed using tagged binding agents
5. Intelligent people have unnatural preferences and values that are novel in human evolution
6. Novel studies of decomposition shed new light on our earliest fossil ancestry
7. Linheng Li proposes novel theory for mammalian stem cell regulation
8. GE Healthcare to evaluate and develop novel imaging technology
9. Novel nanotechnology heals abscesses caused by resistant staph bacteria
10. H1N1 influenza adopted novel strategy to move from birds to humans
11. Lupus Research Institute announces 2009 novel research grants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... Millar , a professor of entomology and ... at the University of California, Riverside, has been ... International Society of Chemical Ecology ( ISCE ). , ... is the society,s highest honor. It is awarded ... chemical ecology, the study of chemicals that mediate interactions ...
(Date:7/21/2014)... save on your utility bill? A paper co-written by ... issue of the journal Environment can help. ... U.S. Households Can Take to Curb Water Use" describes ... actions such as installing more efficient appliances and changing ... be familiar, the researchers are the first to put ...
(Date:7/21/2014)... and cheating in science are among the topics ... mycology experts in Montreal at the three International ... 27 to August 1, 2014. Some 2,000 participants ... the 14th International Congress of Bacteriology and Applied ... Eukaryotic Microbiology, and the 16th International Congress of ...
Breaking Biology News(10 mins):UC Riverside entomologist receives international honor for chemical ecology contributions 2Researchers provide guide to household water conservation 2Researchers provide guide to household water conservation 3Montreal hosts International Union of Microbiology Societies congresses 2
... the near future, solar panels will not only be more ... thanks to research by Nanyang Technological University (NTU) scientists. ... materials, is about five times cheaper than current thin-film solar ... is known to be a remarkable solar cell material as ...
... scientists at the University of Liverpool has found ... present in every infectious disease model would improve ... modelling plays a central role in planning for ... how they might progress and guiding and informing ...
... 21, 2013 Washington Eye Center is proud to announce it ... name was chosen to better reflect the level of accuracy and ... Eastern North Carolina,s leading Ophthalmology and Optometry practice. ... new name of the locations in Greenville , ...
Cached Biology News:NTU scientists make breakthrough solar technology 2NTU scientists make breakthrough solar technology 3Study explores the role of uncertainty in infectious disease modelling 2Washington Eye Center is now Precision Eye Care 2
(Date:7/22/2014)... NJ (PRWEB) July 22, 2014 ... precision, portable, and mechanical balances and scales, proudly ... balances has won Laboratory Equipment magazine’s 2014 “Readers' ... the second consecutive year the Explorer was voted ... The annual Readers’ Choice Awards celebrates “excellence in ...
(Date:7/22/2014)... Massachusetts e SHENZHEN , ... Co., LTD, (BGI Tech), una filiale di BGI, la ... lancio mondiale di un nuovo servizio di sequenziamento dell,intero ... di Complete Genomics. Complete Genomics, molto ... tecnologie di sequenziamento proprietarie con il 99.999% di precisione ...
(Date:7/22/2014)... July 22, 2014 Hussey Copper , ... 29 antimicrobial copper announces Pullman Regional Hospital,s conversion ... EPA-registered antimicrobial solid touch surface, at a nominal cost.  ... MRSA, E-coli and other bacteria within 2 hours of exposure ... against bacteria and infectious diseases in its facilities. ...
(Date:7/22/2014)... , July 22, 2014  The Broad ... million from philanthropist Ted Stanley aimed ... bringing new treatments based on molecular understanding to ... The Stanley commitment – the ... largest for scientific research in general – will ...
Breaking Biology Technology:OHAUS Explorer Voted “Best Balance” in Laboratory Equipment’s 2014 Readers’ Choice Awards 2BGI Tech lancia un servizio di sequenziamento dell'intero esoma umano sulla piattaforma avanzata di Complete Genomics 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 3$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 4$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 5$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 6$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 7$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 8$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 9$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 10
... Overview , ... mixtures using isotope coded affinity tags is to correctly identify ... a spectrum generated by mass spectrometry. Because MALDI-TOF mass spectrometry ... it can be used to quickly screen the ICAT reagent ...
... Lamor, V. Pop and G. Bican, Doping Control Laboratory, Bucharest, Romania ... , Corticosteroids are a class ... potent drugs in the treatment of inflammations and asthma [1]. Corticosteroids ... an athletes ability to concentrate and perform in endurance and power ...
... Morrow, and B. Alexander, TexMS Analytical Services, Houston, TX C. , ... CA , Introduction , ... the pigments in fruits, vegetables, and herbs. There have been reports of ... illnesses, such as rheumatoid arthritis, cancer, cataracts, anxiety, and depression. The objective ...
Cached Biology Technology:Achieving Reliable Protein Quantitation Results Using ICAT Reagents, MALDITOF Mass Spectrometry, and Advanced Data Interpretation Tool 2Achieving Reliable Protein Quantitation Results Using ICAT Reagents, MALDITOF Mass Spectrometry, and Advanced Data Interpretation Tool 3Screening of Corticosteroids in Urine by Negative Atmospheric Pressure Chemical Ionization LC/MS/MS 2Screening of Corticosteroids in Urine by Negative Atmospheric Pressure Chemical Ionization LC/MS/MS 3Screening of Corticosteroids in Urine by Negative Atmospheric Pressure Chemical Ionization LC/MS/MS 4Quantitation of a Dinitro Flavonoid (DNF) in Rat Plasma Using the Varian 1200L LC/MS/MS System 2Quantitation of a Dinitro Flavonoid (DNF) in Rat Plasma Using the Varian 1200L LC/MS/MS System 3
... psi precision pressure regulator and pressurized syringe holder ... liquid-switching Steady flow rate Microinjecting ... Can be added to any new or ... third-party manufacturer, even homemade. Connect to house air ...
...
Chicken polyclonal to UCK2 ( Abpromise for all tested applications). Antigen: Full length protein, corresponding to amino acids 1-261 of Human UCK2 Entrez Gene ID: 7371 Swiss Protein ID: ...
... Recombinant Enterokinase (rEK) is a highly ... bovine enterokinase, a serine protease which recognizes ... enzyme (AspAspAspAspLys↓) and has similar enzymatic activity. ... coli and purified to yield the ...
Biology Products: