Navigation Links
Opposing functions of a key molecule in the development of organisms
Date:3/12/2010

This release is available in Spanish.

Scientists headed by ICREA researcher Marco Miln, at the Institute for Research in Biomedicine (IRB Barcelona), reveal a surprising new function of Notch protein that contrasts with the one known to date. Found in the cell membrane, this protein activates a signalling pathway that regulates the expression of genes that make the cell divide, grow, migrate, specialise or die. Notch activity is required for the correct development of organisms and for the maintenance of tissues in adults. When Notch acts at an incorrect time or in an incorrect context, it can give rise to the generation of tumours, among these leukaemia, breast cancer, colon cancer, skin cancer, lung cancer and renal carcinomas.

"The same pathways responsible for the development and growth of organisms are involved in the transformation of healthy cells into cancerous ones", says Marco Miln, so "all new data on the modulation of Notch activity, the first step in the chain, may be relevant for the design of effective therapies". Marco Miln's group has now discovered that the presence of Notch proteins in the cell membrane is also required to inactivate the pathway. The description of the new role of Notch, found in the fly Drosophila melanogaster, and the mechanism that regulates this function have been published in the journal Current Biology, which belongs to the Cell group.

Stop! Notch is a double agent

In order for the Notch pathway to be activated, ligand-type proteins from neighbouring cells bind to the Notch receptor. When the ligand and receptor come into contact, the Notch receptor is processed and the intracellular part moves to the nucleus to activate gene expression. This is the basic and "extremely simple activation system" of the Notch signalling pathway, which is based on short distance contact between c
'/>"/>

Contact: Snia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. How mitochondrial gene defects impair respiration, other major life functions
2. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
3. Facile synthesis of nanoparticles with multiple functions advanced in Singapore
4. Scientists uncover new class of non-protein coding genes in mammals with key functions
5. Chronic exposure to estrogen impairs some cognitive functions
6. Understanding the functions of diversity
7. Magnet Lab researchers make observing cell functions easier
8. New sensor array detects single molecules for the first time
9. Researchers determine how ATP, molecule bearing the fuel of life, is broken down in cells
10. New cancer-fighting strategy focuses on signaling molecules
11. U. of Colorado scientists create tiny RNA molecule with big implications for lifes origins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Opposing functions of a key molecule in the development of organisms
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION ... new convenient and secure method to make payments.  ... payment methods, introduced with its groundbreaking voice-direct payment ...
(Date:7/9/2015)... DUBLIN , July 07, 2015 ... has announced the addition of the "Biometrics ... and Forecasts 2015-2020" report to their offering. ... a major contributor to this growth and the ... US$5.5 billion in revenue for companies involved in ...
(Date:7/9/2015)... SAN JOSE, Calif. , July 9, ... ), the leading developer of human interface ... authentication technology, the industry,s first fully hardware ... innovative Match-in-Sensor secure authentication technology is literally ... pattern storage and biometric matching within the ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... made progress since 2000, but an annual death toll of ... makes a comeback, the first joint malaria report from the ... says. , The report on the disease that claims three ... today at events in New York, Geneva and Cairo. , ...
... understand the complex processes in the human brain that lead to ... the brains of humans and bees don't look much alike. But ... scientists much about the workings of the primitive portion of our ... alcohol or other drugs. , This region of the brain exerts ...
... incidence of disease from HIV and hepatitis is increasing in ... patients undergoing surgery. Now, researchers have shown that nearly 40 ... patients who tested positive for a bloodborne germ. , "While ... precautions have been in effect for some time to prevent ...
Cached Biology News:Malaria killing a million a year 2Bees, Brains and Addiction 2Scalpel-free surgery could reduce risk of HIV and hepatitis exposure for health care workers 2
(Date:7/31/2015)... ... July 31, 2015 , ... ... detection and quantification of partially hydrolyzed gluten in foods, has been accepted by ... the method “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ELISA,” ...
(Date:7/30/2015)... Dallas, Texas (PRWEB) , ... July 30, 2015 , ... ... professional and in-depth study on the current state of the global Propanol market with ... are Sinopec, CNPC, BASF, Eastman, Dow, Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal ...
(Date:7/30/2015)... ISN improves the efficiency and effectiveness of contractor management systems. ISN,s online contractor management platform, ... 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Dallas, TX , ISN has additional offices in Calgary , ...
(Date:7/30/2015)... ... July 30, 2015 , ... GEA's ... designed for continuous operation up to 1500 bar. The sanitary design gauge of ... preventing toxic contamination. , The Pony™ NS2006L homogenizer is an ideal solution for ...
Breaking Biology Technology:RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2
... ... The 2nd Algae World Europe conference in Brussels addresses ... engineering, marketing and financial aspects of the algae value chain. Panel ... biofuels and high-value co-products like pharmaceuticals, nutraceuticals, cosmetics, aquaculture feed, bioplastics, ...
... , , ... Ltd, a specialty,biopharmaceutical company focused on allergy, today announced ... in a,recently completed phase II clinical trial. Ragweed allergy ... of the population.,Circassia,s latest clinical results follow two earlier ...
... , , , , ... 3SBio Inc. (Nasdaq:, SSRX ), a leading biotechnology company ... in China ,today announced that it has submitted ... to the Chinese State Food and Drug Administration (SFDA).,NuPIAO ...
Cached Biology Technology:2nd Algae World Europe Tracks Algae Commercialization from Algae Production to High-value Products- Nutraceuticals, Aquaculture Feed, Cosmetics, Biofuels and More 22nd Algae World Europe Tracks Algae Commercialization from Algae Production to High-value Products- Nutraceuticals, Aquaculture Feed, Cosmetics, Biofuels and More 3Circassia Achieves Positive Phase II Clinical Results With Ragweed Allergy T-Cell Vaccine 2Circassia Achieves Positive Phase II Clinical Results With Ragweed Allergy T-Cell Vaccine 33SBio Inc. Submits Application for NuPIAO Phase I Clinical Trial 23SBio Inc. Submits Application for NuPIAO Phase I Clinical Trial 3
ANTI S. GROUP AG:H...
Recorder REC-111 single-channel, 1. Category: Chromatography Systems & Accessories, Systems....
For the quantitative determination of cyclic AMP (cAMP) concentrations in cell culture supernates, serum, plasma, saliva, urine and cell lysates....
... WR Cryoscope for molecular weight determinations for petroleum-based applications. Multiple solvents can be used, such ... ... ... ...
Biology Products: