Navigation Links
Opposing functions of a key molecule in the development of organisms
Date:3/12/2010

This release is available in Spanish.

Scientists headed by ICREA researcher Marco Miln, at the Institute for Research in Biomedicine (IRB Barcelona), reveal a surprising new function of Notch protein that contrasts with the one known to date. Found in the cell membrane, this protein activates a signalling pathway that regulates the expression of genes that make the cell divide, grow, migrate, specialise or die. Notch activity is required for the correct development of organisms and for the maintenance of tissues in adults. When Notch acts at an incorrect time or in an incorrect context, it can give rise to the generation of tumours, among these leukaemia, breast cancer, colon cancer, skin cancer, lung cancer and renal carcinomas.

"The same pathways responsible for the development and growth of organisms are involved in the transformation of healthy cells into cancerous ones", says Marco Miln, so "all new data on the modulation of Notch activity, the first step in the chain, may be relevant for the design of effective therapies". Marco Miln's group has now discovered that the presence of Notch proteins in the cell membrane is also required to inactivate the pathway. The description of the new role of Notch, found in the fly Drosophila melanogaster, and the mechanism that regulates this function have been published in the journal Current Biology, which belongs to the Cell group.

Stop! Notch is a double agent

In order for the Notch pathway to be activated, ligand-type proteins from neighbouring cells bind to the Notch receptor. When the ligand and receptor come into contact, the Notch receptor is processed and the intracellular part moves to the nucleus to activate gene expression. This is the basic and "extremely simple activation system" of the Notch signalling pathway, which is based on short distance contact between c
'/>"/>

Contact: Snia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. How mitochondrial gene defects impair respiration, other major life functions
2. Grant supports LSUHSC research on how like cell receptor systems determine very different functions
3. Facile synthesis of nanoparticles with multiple functions advanced in Singapore
4. Scientists uncover new class of non-protein coding genes in mammals with key functions
5. Chronic exposure to estrogen impairs some cognitive functions
6. Understanding the functions of diversity
7. Magnet Lab researchers make observing cell functions easier
8. New sensor array detects single molecules for the first time
9. Researchers determine how ATP, molecule bearing the fuel of life, is broken down in cells
10. New cancer-fighting strategy focuses on signaling molecules
11. U. of Colorado scientists create tiny RNA molecule with big implications for lifes origins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Opposing functions of a key molecule in the development of organisms
(Date:7/30/2014)... today published new research from Bjorn Brembs, professor of ... Germany, with a proof-of-concept figure allowing readers and reviewers ... This represents an important leap forward for scientific ... the quality of a scholarly output. , Figure 3 ... data and their code to F1000Research , and ...
(Date:7/30/2014)... for spinal cord injury (SCI), traumatic brain injury (TBI) ... deal has been learned over the past 30 years ... that regulate axon growth, but this large body of ... Prof. Lemmon and his team from University of Miami ... causes, but a consensus is emerging that one contributing ...
(Date:7/30/2014)... journal Scientific Reports , published by Nature ... that while global temperature is indeed increasing, so too ... each year,s average hottest and coldest temperatures will likely ... a wider range of potential high and low temperate ... even as overall temperatures rise, we may still continue ...
Breaking Biology News(10 mins):F1000Research brings static research figures to life 2Big data confirms climate extremes are here to stay 2
... project to teach undergraduate students about network analysis, turned ... to analyze a National Basketball Association (NBA) basketball team,s ... discovered it is possible to quantify both a team,s ... in an online November issue of PLOS ONE ...
... research from Georgia Aquarium and Georgia Institute of Technology ... can be used to determine the health status of ... fish species. The study, led by Dr. Alistair Dove, ... an adjunct professor at Georgia Tech, found that the ...
... Robertson (Rob) McClung is not your typical clock-watcher. His ... based on a 24-hour period. Living organisms depend upon ... rotation and the recurring changes it imposes on the ... anticipate the changes and adapt to them by modifying ...
Cached Biology News:Basketball teams offer insights into building strategic networks 2New whale shark study used metabolomics to help understand shark and ray health 2Dartmouth research: The clocks are ticking and the climate is changing 2Dartmouth research: The clocks are ticking and the climate is changing 3Dartmouth research: The clocks are ticking and the climate is changing 4
(Date:7/30/2014)... , July 30, 2014 Researchers ... to interrogate biology, but such devices can do ... As such, researchers have looked to ... in vitro metabolic engineering to characterize – ... chip. New devices are envisioned to recreate animal ...
(Date:7/30/2014)... 30, 2014 Connecticut Center for Advanced ... in East Hartford, Conn., was awarded a Rural Business ... a project that will determine the feasibility of implementing ... Connecticut. USDA Rural Development provided $53,000 for CCAT under ... second phase of the feasibility study in fiscal year ...
(Date:7/29/2014)... 2014 SoundConnect , an ... is proud to announce the strategic additions of ... their Boston, Charleston and Atlanta offices. SoundConnect’s ... demand for hosted solutions, collaboration and mobility that ... cost. , SoundConnect was founded in 2004, with ...
(Date:7/29/2014)... 2014 Human Longevity, Inc. (HLI), a genomics ... extending the healthy, high performance human life span, today ... an expert in machine learning and machine translation as ... from Google where he was Distinguished Research Scientist and ... to HLI Co-Founder and CEO, J. Craig Venter ...
Breaking Biology Technology:UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 2USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 3SoundConnect Organization and Culture is Evolving 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3
... such tests on samples sent in from all over Spain. ... truly personalised medicine. And researchers are exploring new ways to ... scale: the genes that are being read or transcribed; the ... the length of the telomeres capping its chromosomes. The ...
... or ultracapacitors, differ from regular capacitors that you would ... store substantially higher amounts of charges. They have garnered ... discharge faster than batteries, yet they are still limited ... energy density of batteries. An EC that combines the ...
... March 16, 2012  Tarsa Therapeutics, Inc. today announced ... financing led by new investor Foresite Capital.  James ... Tarsa,s Board of Directors.  Tarsa,s existing venture capital ... Partners—all participated in the new financing round.  ...
Cached Biology Technology:CNIO researchers take part in the most comprehensive personalized medicine study performed to date 2CNIO researchers take part in the most comprehensive personalized medicine study performed to date 3Researchers develop graphene supercapacitor holding promise for portable electronics 2Researchers develop graphene supercapacitor holding promise for portable electronics 3Researchers develop graphene supercapacitor holding promise for portable electronics 4Tarsa Therapeutics Completes $28 Million Series B Financing to Advance OSTORA™ Oral Calcitonin 2Tarsa Therapeutics Completes $28 Million Series B Financing to Advance OSTORA™ Oral Calcitonin 3Tarsa Therapeutics Completes $28 Million Series B Financing to Advance OSTORA™ Oral Calcitonin 4
... Do you need to make your ... transformation efficiency? Take advantage of Lucigen’s unrivalled ... Custom Competent Cell Service offers: ... transformation efficiencies Fast turnaround ...
Glucagon-like peptide-1 (GLP-1 (1-36) amide)...
... Small Molecule Localization in Early ... Get essential drug compound ... mass spectrometry. Protein Discoverys imaging mass spectrometry ... aligns them with histological images so you ...
Best pricing for 100mg-1.0g scales. Phosphopeptides are our specialty....
Biology Products: