Navigation Links
Open science journal publishes attempt to reproduce high-profile stem cell acid bath study
Date:5/8/2014

In a study published today in F1000Research, Professor Kenneth Lee of the Chinese University of Hong Kong reveals the full experimental results of an attempt to replicate a controversial study published in Nature recently that suggested that bathing somatic cells in acid can reprogram them to induced pluripotent stem cells (iPS cells). With systematically collected and fully available data, Lee and his colleagues report that carefully replicating the original acid-treatment method does not induce pluripotency in two types of mouse somatic cells, including those used in the original study.

iPS cells have the unique ability to give rise to most other cell types, and have potentially wide therapeutic applications. This characteristic can be triggered in other cells by transforming them into iPS cells, which further increases the potential for stem cell therapies. Earlier this year, a group from Japan reported a greatly simplified procedure for producing iPS cells by bathing somatic cells in an acid bath.

To verify these claims, Kenneth Lee set out to replicate the work in his own lab, and documented his experiments online in the process, leading to lively online discussions between stem cell scientists who provided feedback and commentary along the way. Using both white blood cells isolated from the spleen of neonatal mice - the same cells used in the original study - and lung fibroblasts, Lee was unable to replicate the original findings, and has now published the full results of his study in F1000Research.

Unlike most journals, all research papers in the open access journal F1000Res
'/>"/>

Contact: Eleanor Howell
press@f1000.com
44-020-763-19129
Faculty of 1000
Source:Eurekalert

Page: 1 2

Related biology news :

1. National Academy of Sciences elects Cary Institute of Ecosystem Studies scientist
2. National Academy of Sciences elects 5 from UChicago, Marine Biological Laboratory
3. Study in Science finds missing piece of biogeochemical puzzle in aquifers
4. Jerry Melillo of MBL Ecosystems Center elected to National Academy of Sciences
5. Arizona State University professor is elected to the National Academy of Sciences
6. BRIC carries big science in small canisters
7. Two San Diego scientists elected to the National Academy of Sciences
8. New Translational Addiction Sciences Center poised to make headway in treatment of addiction
9. ESA to publish the Journal of Insect Science
10. Bioethicists use theatrical narratives to bridge the gap between society and science
11. PETA science consortium to present hazard testing strategy at nanotoxicology meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , November 18, 2014 According ... Market by Systems (Video, RFID, Access Control, Intrusion Detection, ... Hotels, Banks, Government), Component Service Geography - Global Forecasts ... Market is projected to be around $25 Billion in ... 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... -- C-Labs LLC, a leading provider of remote and ... announced the appointment of John Traynor to ... advisor to the firm, Mr. Traynor will now oversee ... out of the C-Labs office in Redmond, ... , Chief Executive Officer. Photo - ...
(Date:11/18/2014)... , Nov. 17, 2014   ... EMC collaborate to develop The Partners Data Lake, ... The Partners Data Lake will allow researcher and ... diagnostics, treatment and the lives of patients ... and clinical activities across the Partners system, breaking ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... 2012Aspera, Inc., creators of next-generation software technologies that ... BGI, the world,s largest genomics research institute, today ... to integrate and deploy the Aspera Connect Server ... "EasyGenomicsTM", BGI,s latest cloud-based Software as a Service ...
... British Heart Foundation (BHF), has tested a new imaging method ... of having a heart attack (1). Scientists from ... in collaboration with the University of Cambridge are the first ... to image the disease processes directly in the coronary arteries ...
... anti-depressants appear to be doing patients more harm than good, ... of the medications on the entire body., "We need to ... drugs," says Paul Andrews, an evolutionary biologist at McMaster University ... online journal Frontiers in Psychology ., "It,s important ...
Cached Biology News:BGI and Aspera collaborate on high-speed data exchange to advance genome research 2Scientists develop new technique that could improve heart attack prediction 2Evidence shows that anti-depressants likely do more harm than good, researchers find 2
(Date:12/22/2014)... The Center for Professional Innovation ... training across the life sciences industry, has partnered with ... to provide the organization's members with discounted classroom courses, ... the more than 350 sessions across 80 course titles. ... when registering for a public course at ...
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ - RepliCel Life ... regenerative medicine company focused on the development of autologous ... out of the University of Calgary in conjunction with ... Carolina, which further validates the company,s ongoing clinical research ... effects of pattern baldness. The paper entitled ...
(Date:12/22/2014)... Dec. 22, 2014 GenomeDx Biosciences today announced ... Cancer Classifier, a genomic test for prostate cancer, was ... men managed by radical prostatectomy without adjuvant therapy. Although ... relatively uncommon, using tumor genomics to identify these men ... is an important advance. The study has been ...
(Date:12/22/2014)... 22, 2014 The American ... of original research, reviews and editorials addressing developments ... practice, today published a provocative article exploring the ... progression and potential treatment of prostate cancer. ... and proposes the possibility that there could be ...
Breaking Biology Technology:CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4
... QUEBEC CITY, June 3, 2011 Asmacure ... of nicotinic receptor agonists for the treatment of asthma ... has been appointed as chief executive officer.  With a ... the company as it progresses its lead compound, a ...
... /PRNewswire-Asia-FirstCall/ -- China Cord Blood Corporation (NYSE: CO ... results for the fourth quarter and full year of fiscal ... in the US.   The Company will hold ... 13, 2011 to discuss its financial performance and give a ...
... Pharmaceuticals, Inc. (Nasdaq: ANTH ), today announced ... common stock in an underwritten public offering.  The Company expects ... to an additional 15% of the shares of common stock ...  Citi and Leerink Swann LLC are acting as joint book-running ...
Cached Biology Technology:Asmacure Ltee Appoints Pharmaceutical and Biotechnology Industry Veteran Martin Driscoll as CEO 2Asmacure Ltee Appoints Pharmaceutical and Biotechnology Industry Veteran Martin Driscoll as CEO 3China Cord Blood Corporation to Report Fourth Quarter and Full Year Fiscal 2011 Financial Results 2Anthera Pharmaceuticals Announces Proposed Public Offering of Common Stock 2Anthera Pharmaceuticals Announces Proposed Public Offering of Common Stock 3
... Cycler is the ideal instrument for budget-conscious labs ... PCR applications. Get Applied Biosystems proven ... Save lab space without sacrificing results. ... PCR Technology You Can Afford The ...
... [6331] to Salmonella typhimurium The genus Salmonella ... genus is composed of Gram-negative bacilli that are ... antigens; the "H" or flagellar antigen (phase 1 ... of the LPS moiety) and the "Vi" or ...
... 36 mg/L sodium pyruvate, 50 mg/L streptomycin ... glucose, calcium chloride, and magnesium chloride. The ... in tissue culture is generally attributed to ... Sydney Ringer developed a solution of inorganic ...
... micro 1 is a dramatic breakthrough in accurate, ... with 10nL resolution, the micro 1 has unique ... And, the micro 1 never needs re-calibration as ... Screen programming on an LCD Display , Graphical ...
Biology Products: