Navigation Links
Oocyte-specific gene mutations cause premature ovarian failure
Date:5/22/2008

Mutations in a gene called FIGLA cause premature ovarian failure in at least a percentage of women who suffer from the disorder, said researchers from Baylor College of Medicine in Houston and Shandong University in China in a report that appears online today in the American Journal of Human Genetics.

We hope to use the information from this study and others that identify genes associated with this problem to find biomarkers in blood that can help us determine a womans risk of early infertility, said Dr. Aleksandar Rajkovic, associate professor of obstetrics and gynecology at BCM and senior author of the paper. Premature ovarian failure, which means that the ovaries lose function before age 40, not only causes infertility but also bone and heart problems, he said.

It affects 1 percent of women, he said. While most people associate it with infertility, women with premature ovarian failure face an increased risk of cardiovascular disease, osteoporosis and premature death. Ovarian reserves are important for womens health.

In looking for genes that cause the disorder, Rajkovic and his colleagues here and in China concentrated on those that are most likely to function in the ovary. A gene mutation does not totally halt gene activity, but Rajkovic believes it can accelerate the loss of eggs (or germ cells). When all the eggs are lost, the ovaries stop producing estrogen, leading to menopause symptoms.

In this study, Rajkovic and his collaborators screened 100 Chinese women with premature ovarian failure for mutations in FIGLA and found three different kinds of mutations in the FIGLA genes of four.

FIGLA is one of four transcription factors found to control the differentiation of egg cells early in development. Transcription factors govern the activity of genes, turning them off and on and modulating the extent to which they are active.

The other genes involved include NOBOX, GDF9 and BMP 15, said Rajkovic. Mut
'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
2. Rare genetic mutations protect against hypertension
3. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
4. Should children be permitted to get genetic testing for BRCA 1/2 mutations?
5. New study reveals for first time how BRCA1 mutations cause breast cancer
6. NASA study links Earth impacts to human-caused climate change
7. Bacterial slime helps cause serious disease
8. Butter-flavored popcorn ingredient suspected cause of lung disease
9. Cause and affect: Emotions can be unconsciously and subliminally evoked, study shows
10. Kids with autism may have gene that causes muscle weakness
11. A genetic cause for iron deficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced that Huawei has selected the Synaptics ® ... stylish smartwatch. Huawei chose the state-of-the-art ClearPad capacitive ... and highly responsive human interface qualities such as ... required a classic round watch face and Synaptics ...
(Date:7/21/2015)... Today, ZTE announced its Android smartphone Axon, ... expected revenues in 2015 that relate to sales of FPC1025 for ... approximately 2,200 MSEK for 2015. Jörgen Lantto, CEO of ... in China and we are proud that ... for Axon , its first ...
(Date:7/13/2015)... JOSE, Calif. , July 13, 2015 /PRNewswire/ ... leading developer of human interface solutions, today announced ... generation touch and display driver integration (TDDI) product ... is the first to combine Synaptics , ... with proven display driver technology developed in the ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3
... virtual reality forest, will anyone hear an environmental message? They ... the make-believe redwood. New findings from Stanford researchers show that ... to saw through a towering sequoia until it crashed in front ... people who only imagined what it,s like to cut down a ...
... will present techniques and discuss surgical approaches and applications ... Association of Neurological Surgeons (AANS), held April 9-13, 2011 ... The Department of Neurosurgery at NYU Langone Medical Center ... hospitals in the country for neurology and neurosurgery by ...
... Mohammad Golabi, a soil science professor at the University of ... to practical use in shielding the reefs in Pago Bay ... of the major health hazards facing Guam,s reefs is soil ... that make up a reef system. "Vetiver,s ability to tolerate ...
Cached Biology News:Stanford's virtual reality lab focuses on conservation 2Stanford's virtual reality lab focuses on conservation 3NYU Langone experts present advances at American Association of Neurological Surgeons Meeting 2Bioengineering with vetiver grass on Guam 2
(Date:7/30/2015)... WARRINGTON, Pa. , July 30, 2015 /PRNewswire/ ... announced that it has received the second $1.0M ... Business Innovation Research (SBIR) grant valued at up ... the company,s aerosolized KL4 surfactant as a potential ... lung injury.  Discovery Labs was awarded an initial ...
(Date:7/29/2015)... July 30, 2015 Sanofi, ... for the second quarter of 2015. CEO ... and its performance in different businesses. ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Topics covered in ... - Performance drivers - ...
(Date:7/29/2015)... US-Australian drug discovery company, Novogen Limited (ASX: NRT; NASDAQ: ... progressing its ground-breaking technology platforms to Phase 1 clinical ... Company delivers the best value for shareholders. ... the Company currently had an extensive program of activities ... academic partnerships and initiatives, and he was working with ...
(Date:7/29/2015)...  HealthSouth Corporation (NYSE: HLS ), one ... services, offering both facility-based and home-based post-acute services, ... second quarter ended June 30, 2015. ... growth in both segments and an 11.0% increase ... and Chief Executive Officer of HealthSouth. "While reported ...
Breaking Biology Technology:Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10HealthSouth Reports Results for Second Quarter 2015 2HealthSouth Reports Results for Second Quarter 2015 3HealthSouth Reports Results for Second Quarter 2015 4HealthSouth Reports Results for Second Quarter 2015 5HealthSouth Reports Results for Second Quarter 2015 6HealthSouth Reports Results for Second Quarter 2015 7HealthSouth Reports Results for Second Quarter 2015 8HealthSouth Reports Results for Second Quarter 2015 9HealthSouth Reports Results for Second Quarter 2015 10HealthSouth Reports Results for Second Quarter 2015 11HealthSouth Reports Results for Second Quarter 2015 12HealthSouth Reports Results for Second Quarter 2015 13HealthSouth Reports Results for Second Quarter 2015 14HealthSouth Reports Results for Second Quarter 2015 15HealthSouth Reports Results for Second Quarter 2015 16HealthSouth Reports Results for Second Quarter 2015 17HealthSouth Reports Results for Second Quarter 2015 18HealthSouth Reports Results for Second Quarter 2015 19HealthSouth Reports Results for Second Quarter 2015 20HealthSouth Reports Results for Second Quarter 2015 21HealthSouth Reports Results for Second Quarter 2015 22HealthSouth Reports Results for Second Quarter 2015 23HealthSouth Reports Results for Second Quarter 2015 24HealthSouth Reports Results for Second Quarter 2015 25
... Jan. 26 Today,s DuPont (NYSE: ... extra comma which could lead to misinterpretation.  The Outlook section ... the company now expects pension expense to be about ... statement should have read: "Due to strong pension fund performance, ...
... New Method Bypasses Need to Obtain Stem Cells From Embryos ... -- The scientist who reprogrammed adult cells into embryonic-like stem cells ... Developmental Biology. , Shinya Yamanaka , MD, PhD, of the ... University , Japan , will be honored with the 2010 March ...
... , ... country, you may be asking how the billions poured into science R&D has helped stimulate ... CA. 2009 just ended as their first branded year with new hires, new instruments and ... ...
Cached Biology Technology:March of Dimes Awards $250,000 Prize to Scientist Who Discovered How to Reprogram Human Cells 2US Nanotechnology Instrument Manufacturer Proves the Success of R&D Stimulus 2
Mouse Laminin-1 MAb (Clone AL-3)...
IEX-1 S/L (H-20)...
... Strong reactivity with rat ... and guinea pig (48%). ... Specificity confirmed by Western ... Goa, rat Gia-1, Gia-2, rat ...
IgG2b, k APC clone A95-1, Isotype Rat IgG2b, kappa, 0.1 mg ....
Biology Products: