Navigation Links
Oocyte-specific gene mutations cause premature ovarian failure
Date:5/22/2008

Mutations in a gene called FIGLA cause premature ovarian failure in at least a percentage of women who suffer from the disorder, said researchers from Baylor College of Medicine in Houston and Shandong University in China in a report that appears online today in the American Journal of Human Genetics.

We hope to use the information from this study and others that identify genes associated with this problem to find biomarkers in blood that can help us determine a womans risk of early infertility, said Dr. Aleksandar Rajkovic, associate professor of obstetrics and gynecology at BCM and senior author of the paper. Premature ovarian failure, which means that the ovaries lose function before age 40, not only causes infertility but also bone and heart problems, he said.

It affects 1 percent of women, he said. While most people associate it with infertility, women with premature ovarian failure face an increased risk of cardiovascular disease, osteoporosis and premature death. Ovarian reserves are important for womens health.

In looking for genes that cause the disorder, Rajkovic and his colleagues here and in China concentrated on those that are most likely to function in the ovary. A gene mutation does not totally halt gene activity, but Rajkovic believes it can accelerate the loss of eggs (or germ cells). When all the eggs are lost, the ovaries stop producing estrogen, leading to menopause symptoms.

In this study, Rajkovic and his collaborators screened 100 Chinese women with premature ovarian failure for mutations in FIGLA and found three different kinds of mutations in the FIGLA genes of four.

FIGLA is one of four transcription factors found to control the differentiation of egg cells early in development. Transcription factors govern the activity of genes, turning them off and on and modulating the extent to which they are active.

The other genes involved include NOBOX, GDF9 and BMP 15, said Rajkovic. Mut
'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
2. Rare genetic mutations protect against hypertension
3. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
4. Should children be permitted to get genetic testing for BRCA 1/2 mutations?
5. New study reveals for first time how BRCA1 mutations cause breast cancer
6. NASA study links Earth impacts to human-caused climate change
7. Bacterial slime helps cause serious disease
8. Butter-flavored popcorn ingredient suspected cause of lung disease
9. Cause and affect: Emotions can be unconsciously and subliminally evoked, study shows
10. Kids with autism may have gene that causes muscle weakness
11. A genetic cause for iron deficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... gathered at NJIT this week for an all-day public ... Environmental Protection Agency (EPA) to dredge toxic sediment from ... The EPA has called the plan, which proposes removing ... sections of the riverbed, one of the largest cleanups ... dredged and disposed off-site. , "We need to ensure ...
(Date:7/24/2014)... A yearlong study funded by the New Jersey ... J. Bloustein School of Planning and Public Policy at ... Sandy-affected towns are skeptical about the likelihood of community-based ... respondents, 45 percent indicated they were "pessimistic" or "very ... Superstorm Sandy would be rebuilt better than they were ...
(Date:7/24/2014)... of fires covered central Africa in mid-July 2014, as ... red hotspots, which indicate areas of increased temperatures, are ... Democratic Republic of the Congo (northeast), and Zambia (southeast). ... and in some areas, especially in the Democratic Republic ... the south. , The fire season is an annual ...
Breaking Biology News(10 mins):Experts Weigh the Pros and Cons of a $1.7 Billion EPA Cleanup Plan for the Passaic River at an NJIT 2Rutgers study explores attitudes, preferences toward post-Sandy rebuilding 2
... Pediatric neuroscientists at Oregon Health & Science University Doernbecher ... field strength MRI to reveal tiny white matter injuries ... Early, accurate identification of these lesions in ... and enable physicians to inform families sooner of the ...
... This press release is available in German ... Zagheni of the Max Planck Institute for Demographic Research in ... between age and average per capita CO2 emissions. This profile ... easily accessible. But the demographic-economic model developed for the analysis ...
... international consortium of 15 institutions from 12 European ... Norway, Romania, Sweden, The Netherlands, UK) has started ... The name stands for ,Biodiversity and Ecosystem Services: ... the effectiveness of arguments used for biodiversity protection ...
Cached Biology News:First use of high-field MRI in developing brain reveals previously undetectable injuries 2Individual CO2 emissions decline in old age 2Individual CO2 emissions decline in old age 3Individual CO2 emissions decline in old age 4
(Date:7/24/2014)... Yet, scientists are making progress in devising suitable ... approach relies on quantum dotsa kind of artificial ... A new study demonstrates that changing the coupling ... electrical impulses can help better control them. This ... as quantum information units, which would produce faster ...
(Date:7/24/2014)... July 24, 2014 Research and Markets ... Genomics and Proteomics Analytical Instruments Market 2014-2018" report ... Genomics is the study of the ... of the structure and functions of proteomes or sets ... and technology. Genomics involves the mapping of genes and ...
(Date:7/24/2014)... 2014 Three companies from the angelMD ... Big C Competition. Out of 700 competition entrants, Chiron ... the semi-final round. In this round twenty teams are ... complete with mentoring from thought-leaders and medical entrepreneurs from ... the angelMD commitment to the Livestrong vision around the ...
(Date:7/24/2014)... 2014 1000 balances – 4 steps ... customers’ weighing needs and expertly narrows down the mass ... scales or even terminals. , First, select the ... (or select readability instead) and define the accuracy – ... criteria narrows down the list to models that fit ...
Breaking Biology Technology:Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 23 angelMD Startups Make Livestrong Big C Semi-finals 2
... burn treatment market,experienced growth of 7.6% from 2001 to ... a new report by Kalorama Information,projects that the market ... price,constraints, new technologies, and additional market penetration, but will,grow ... products continue to generate the majority of,sales. However, their ...
... Provides Ability to Integrate with Multiple Disparate ... ... Diagnostic Turnaround, CHICAGO, Nov. 26 RSNA Booth ... seamless connectivity and,interoperability between diagnostic acquisition devices, PACS, HIS, ...
... WALTHAM, Mass., Nov. 26 Millennium Research ... data from both orthopedic surgeons and rheumatologists, shows ... Q3 2007 compared to Q3,2006. While treatments are ... the products they use in these procedures., ...
Cached Biology Technology:Bio-advancements Expected to Drive Burn Care Market Growth Up $700 Million 2E-Rad Solutions Selects Compressus' Enterprise Systems Integration Technology to Fuel Entry Into Teleradiology Market 2E-Rad Solutions Selects Compressus' Enterprise Systems Integration Technology to Fuel Entry Into Teleradiology Market 3Hyaluronic Acid Knee Procedures Grow 38% from Q3 2006 to Q3 2007 2
Glutamate Receptor 5/1a...
... [EP282Y] to Asparagine synthetase ( ... applications). Antigen: ... residues in the C-terminus of ... Entrez GeneID: 440 ...
Shh Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Anti-human C5/C5b, Clone 568, Monoclonal Antibody...
Biology Products: