Navigation Links
Oocyte-specific gene mutations cause premature ovarian failure
Date:5/22/2008

Mutations in a gene called FIGLA cause premature ovarian failure in at least a percentage of women who suffer from the disorder, said researchers from Baylor College of Medicine in Houston and Shandong University in China in a report that appears online today in the American Journal of Human Genetics.

We hope to use the information from this study and others that identify genes associated with this problem to find biomarkers in blood that can help us determine a womans risk of early infertility, said Dr. Aleksandar Rajkovic, associate professor of obstetrics and gynecology at BCM and senior author of the paper. Premature ovarian failure, which means that the ovaries lose function before age 40, not only causes infertility but also bone and heart problems, he said.

It affects 1 percent of women, he said. While most people associate it with infertility, women with premature ovarian failure face an increased risk of cardiovascular disease, osteoporosis and premature death. Ovarian reserves are important for womens health.

In looking for genes that cause the disorder, Rajkovic and his colleagues here and in China concentrated on those that are most likely to function in the ovary. A gene mutation does not totally halt gene activity, but Rajkovic believes it can accelerate the loss of eggs (or germ cells). When all the eggs are lost, the ovaries stop producing estrogen, leading to menopause symptoms.

In this study, Rajkovic and his collaborators screened 100 Chinese women with premature ovarian failure for mutations in FIGLA and found three different kinds of mutations in the FIGLA genes of four.

FIGLA is one of four transcription factors found to control the differentiation of egg cells early in development. Transcription factors govern the activity of genes, turning them off and on and modulating the extent to which they are active.

The other genes involved include NOBOX, GDF9 and BMP 15, said Rajkovic. Mut
'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
2. Rare genetic mutations protect against hypertension
3. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
4. Should children be permitted to get genetic testing for BRCA 1/2 mutations?
5. New study reveals for first time how BRCA1 mutations cause breast cancer
6. NASA study links Earth impacts to human-caused climate change
7. Bacterial slime helps cause serious disease
8. Butter-flavored popcorn ingredient suspected cause of lung disease
9. Cause and affect: Emotions can be unconsciously and subliminally evoked, study shows
10. Kids with autism may have gene that causes muscle weakness
11. A genetic cause for iron deficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... 20, 2015 Research and Markets ... the "India Sensors Market Forecast and Opportunities ... The sensor market is projected to grow at ... Consumer electronics, automotive, industrial and healthcare sectors are ... country. In addition, adoption of MEMS technology in ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report ... markets for Iris Biometrics in US$ Thousands. The report provides ... , Japan , Europe ... , and Latin America . ...
(Date:3/17/2015)... , March 17, 2015 MedNet ... specializing in clinical study management systems, is pleased ... attendance at ARENA,s Outsourcing in Clinical Trials Southeast ... event provides an excellent forum for MedNet to ... and affordable software-as-a-service (SaaS) eClinical technology platform. ...
Breaking Biology News(10 mins):India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... we knowfor sure. Adding to a growing literature ... sperm ,function, it is now shown that one lactate dehydrogenase ... of ,work on this glycolytic enzyme had shown that it ... been ,only speculative. In an article on p. 26 Odet ...
... spring apples from the southern hemisphere as they enter the ... that has swept the industrialized world over the past couple ... complicated global process that has changed every aspect of how ... supermarkets in a country should bring with it the "cheap ...
... into the mechanisms that underlie long-term memory research with ... "The more we know about how long-term memory is ... in the brain, the more we are going to be ... professor of physiological science and neurobiology, whose new research appears ...
Cached Biology News:July 2008 highlights 2Lost in the supermarket? 2Study of marine snail leads to new insights into long-term memory 2Study of marine snail leads to new insights into long-term memory 3Study of marine snail leads to new insights into long-term memory 4
(Date:4/16/2015)... Spirax Sarco, the leader in ... newly designed, state-of-the-art website in the first quarter ... promotes the Spirax Sarco brand, company capabilities, and ... a site visitor might be looking for including ... serviced, the latest company news, careers, and much ...
(Date:4/16/2015)... FL (PRWEB) April 16, 2015 ... cap distribution and physician network in Europe and ... company has appointed Fernando Bermúdez, former Business Development ... , An industry veteran, Mr. Bermúdez’s professional achievements ... 75% in Spain, while also penetrating the Portuguese ...
(Date:4/16/2015)... Streetsboro, Ohio (PRWEB) April 16, 2015 ... Safety Index, overexertion involving an outside source was ... injuries. This includes injuries related to lifting, pushing, ... $15.1 billion in direct costs. The David Round ... Round is committed to working hard to develop ...
(Date:4/16/2015)... /PRNewswire/ - Portage Biotech Inc. ("Portage" or "the Company" ... pleased to announce that the Company will be presenting ... to be held in London, UK ... Mr. James Mellon , a director of Portage, ... key programs at its subsidiaries, Portage Pharmaceuticals Ltd. ("PPL"), ...
Breaking Biology Technology:Spirax Sarco website has a new look 2Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4
... new data and program updates on cancer stem cell targeting ... ... /PRNewswire-FirstCall/ - ARIUS Research Inc., (TSX:,ARI), a biotechnology company discovering and ... be presenting new,findings and program updates related to its CD44, TROP-2, ...
... Ltd.,(SWX: ARPN) today announced that it will host ... 8.30am CET. In this conference call, a leading ... the area of anti-infective,drugs as well as the ... Advisory Committee. During that meeting, the committee discussed,product ...
... Chairman & CEO, Paul Willis,stated, "Just like his ... Whitacre has risen fast at Cypress Systems, Inc, last ... of operations.",Now Cypress and Whitacre are focusing their energy ... Americans -- and people around the,world -- to consume ...
Cached Biology Technology:ARIUS presents new findings for anti-cancer antibody programs at AACR 2ARIUS presents new findings for anti-cancer antibody programs at AACR 3ARIUS presents new findings for anti-cancer antibody programs at AACR 4ARIUS presents new findings for anti-cancer antibody programs at AACR 5Arpida Announces Conference Call on 17 April 2Arpida Announces Conference Call on 17 April 3Cypress Systems, Inc. Launches Cancer Prevention Health Campaign Using SelenoExcell(R) 2Cypress Systems, Inc. Launches Cancer Prevention Health Campaign Using SelenoExcell(R) 3