Navigation Links
Oocyte-specific gene mutations cause premature ovarian failure
Date:5/22/2008

Mutations in a gene called FIGLA cause premature ovarian failure in at least a percentage of women who suffer from the disorder, said researchers from Baylor College of Medicine in Houston and Shandong University in China in a report that appears online today in the American Journal of Human Genetics.

We hope to use the information from this study and others that identify genes associated with this problem to find biomarkers in blood that can help us determine a womans risk of early infertility, said Dr. Aleksandar Rajkovic, associate professor of obstetrics and gynecology at BCM and senior author of the paper. Premature ovarian failure, which means that the ovaries lose function before age 40, not only causes infertility but also bone and heart problems, he said.

It affects 1 percent of women, he said. While most people associate it with infertility, women with premature ovarian failure face an increased risk of cardiovascular disease, osteoporosis and premature death. Ovarian reserves are important for womens health.

In looking for genes that cause the disorder, Rajkovic and his colleagues here and in China concentrated on those that are most likely to function in the ovary. A gene mutation does not totally halt gene activity, but Rajkovic believes it can accelerate the loss of eggs (or germ cells). When all the eggs are lost, the ovaries stop producing estrogen, leading to menopause symptoms.

In this study, Rajkovic and his collaborators screened 100 Chinese women with premature ovarian failure for mutations in FIGLA and found three different kinds of mutations in the FIGLA genes of four.

FIGLA is one of four transcription factors found to control the differentiation of egg cells early in development. Transcription factors govern the activity of genes, turning them off and on and modulating the extent to which they are active.

The other genes involved include NOBOX, GDF9 and BMP 15, said Rajkovic. Mut
'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
2. Rare genetic mutations protect against hypertension
3. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
4. Should children be permitted to get genetic testing for BRCA 1/2 mutations?
5. New study reveals for first time how BRCA1 mutations cause breast cancer
6. NASA study links Earth impacts to human-caused climate change
7. Bacterial slime helps cause serious disease
8. Butter-flavored popcorn ingredient suspected cause of lung disease
9. Cause and affect: Emotions can be unconsciously and subliminally evoked, study shows
10. Kids with autism may have gene that causes muscle weakness
11. A genetic cause for iron deficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... Forest Baptist Medical Center today announced plans for a ... Funding for this $50 million capital project is part ... launched next summer. The medical education ... R.J. Reynolds Tobacco Company complex, adjacent to 525@vine in ... plans to be ready to welcome medical students in ...
(Date:12/5/2014)... , Dec. 4, 2014 Increased ... boosted investments in new testing and inspection technologies. ... given rise to a range of innovative test ... requirements of Generation Y, which is generally more ... a result, product development strategies of test equipment ...
(Date:12/3/2014)... 2, 2014 As part of our commitment ... is pleased to announce the release of a new ... collect the workforce data that they need. ... left by existing readers. Many such devices have serious ... modern technology. Older models force users to navigate numerous ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2
... pacemakers have saved and extended the lives of thousands of ... a fixed pulse rate and a limited life. Could a ... colleagues at New York,s Columbia and Stony Brook Universities certainly ... of The Journal of Physiology brings the dream ...
... in the journal Development ( dev.biologists.org ) ... a type of cell that can make myelin, a ... and clinical research. The cells the researchers made ... in the central nervous system. Myelin forms an insulating ...
... 8 Supply Chain Council (SCC) will host at ... events around the internationally used standard, the Supply Chain ... 2009 , SCOR Seminar - 13-14 May 2009 , ... SCOR with other frameworks and methodologies specifically for the ...
Cached Biology News:Towards a natural pacemaker 2Human ES cells progress slowly in myelin's direction 2Supply Chain Council Seminar Focuses on Defense and IT 2
(Date:12/22/2014)... 22, 2014 /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: ... focused on the development of autologous cell therapies, announced ... University of Calgary in conjunction with co-authors from Kyoto ... validates the company,s ongoing clinical research using dermal sheath ... baldness. The paper entitled " Hair Follicle ...
(Date:12/22/2014)... SAN DIEGO , Dec. 22, 2014 ... that the Decipher Prostate Cancer Classifier, a genomic test ... disease in node-negative, high-risk men managed by radical prostatectomy ... with radical prostatectomy is relatively uncommon, using tumor genomics ... form of metastatic disease is an important advance. The ...
(Date:12/22/2014)... December 22, 2014 The ... publication of original research, reviews and editorials addressing ... clinical practice, today published a provocative article exploring ... development, progression and potential treatment of prostate cancer. ... research and proposes the possibility that there could ...
(Date:12/22/2014)... 2014 Fertility Associates of Memphis has ... USA , a network of more than 20 contributing ... patients have fast access to a national pool of ... . Fertility Associates of Memphis is the only fertility ... option. , Dr. William Kutteh , director of ...
Breaking Biology Technology:Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3
... N.C., Sept. 2 Sicel Technologies, Inc., announced ... into involuntary bankruptcy. Effective August 31, 2010, Paul ... Director of the company. Currently, Sicel,s operations are ... furloughed have returned to work.Media Contact: Lisa P. ...
... EUCODIS Bioscience Appoints Two Industry Executives to Realigned Advisory Board -- VIENNA, Austria, September 2, 2010 ... ... (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we need ...
... and the Wyss Institute for Biologically Inspired Engineering ... one of the most microscopic forms of lifebacteria. ... Nature . In studying the development of ... populations most adept at withstanding doses of antibiotics are ...
Cached Biology Technology:EUCODIS Bioscience Appoints Two Industry Executives to Realigned Advisory Board 2EUCODIS Bioscience Appoints Two Industry Executives to Realigned Advisory Board 3EUCODIS Bioscience Appoints Two Industry Executives to Realigned Advisory Board 4EUCODIS Bioscience Appoints Two Industry Executives to Realigned Advisory Board 5EUCODIS Bioscience Appoints Two Industry Executives to Realigned Advisory Board 6EUCODIS Bioscience Appoints Two Industry Executives to Realigned Advisory Board 7Charitable behavior found in bacteria 2
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
Shake 'n' Stack oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual)...
DNase I (Deoxyribonuclease I) digests single- and double-stranded DNA to oligodeoxyribonucleotides. Ribonuclease activity has been reduced to non-detectable levels....
... coli containing a clone of the human Topoisomerase ... II alters the topological state of nucleic acids ... transient break which generates a separate DNA helix ... DNA passage mechanism, the enzyme can relax negatively ...
Biology Products: