Navigation Links
One gene, many tissues
Date:3/27/2014

Genes are the "code" for building the biological elements that form an organism. The DNA that makes up genes contains the instructions to synthesise proteins, but it's wrong to think that, for a given gene, these instructions are always the same for all parts of the organisms. In actual fact, the gene varies depending on the tissue where it is located (cerebral cortex, cerebellum, olfactory epithelium, etc.); in particular, what varies is the point in the "string" of code at which protein synthesis starts. This complexity complicates the work of scientists considerably, but projects like FANTOM come to their aid. FANTOM is in fact an international consortium that brings together several dozens of laboratories worldwide and has recently published a paper providing an exhaustive map of these specificities. The Neurogenomics Laboratory of SISSA, coordinated by Stefano Gustincich is among the participating laboratories.

"FANTOM has existed for about fourteen years and the published paper is the result of the fifth phase of the project," explains Stefano Gustincich. "Each of the participating laboratories sent in several biological samples all of which were examined using the same methodology".

In particular, the researchers used CAGE technology which, unlike more traditional methods, analyses only the first nucleotides of messenger RNA. Messenger RNA is a small piece of genetic material that the DNA uses to sythesize proteins, a sort of carbon copy of part of the information contained in the gene. Nucleotides are the small beads that make up the "string" of DNA and RNA. "By analysing the first nucleotides we are able to identify which sequence of gene starts the transcription. For any given gene, this sequence in fact changes depending on the tissue in which it is located. This way, we know where the gene starts to do its work" continues Gustincich. "Finding the beginning of the active portion also enables us to identify the 'promoter', that i
'/>"/>

Contact: federica sgorbissa
pressroom@sissa.it
39-040-378-7644
International School of Advanced Studies (SISSA)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. One gene, many mutations
2. New biological scaffold offers promising foundation for engineered tissues
3. An essential step toward printing living tissues
4. Regenerating orthopedic tissues within the human body
5. Researchers regrow hair, cartilage, bone, soft tissues
6. Fetal tissue-derived stem cells may be ideal source for repairing tissues and organs
7. New protocol developed to decontaminate human fetal tissues used for cell transplantation
8. Ovarian cancer metastases influenced by factors in target tissues
9. Stem cell-based bioartificial tissues and organs
10. New methods for quantifying antisense drug delivery to target cells and tissues
11. 3-D biomimetic scaffolds support regeneration of complex tissues from stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
One gene, many tissues
(Date:7/2/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ) ... Biometrics Market by Application, Technology, Function & Geography - ... The next generation biometrics market is expected ... of 17.9% between 2015 and 2020 Travel ... Safran SA ( France ), ...
(Date:6/29/2015)... , June 24, 2015 ... of the "Latin America Biomedical Sensors Market - ... offering. The Latin America Biomedical Sensors market ... CAGR of 2.04% over the period 2014-2020 ... adaptable to the genetic formulation of each individual. These ...
(Date:6/25/2015)... June 25, 2015  TAKE Solutions Ltd., a global ... the United States Patent and Trademark Office (USPTO) for ... leverages TAKE Solutions, Clinical Accelerators to reduce the time ... compared to standardization without the accelerators), thus reducing time ... At the heart of the patented Clinical ...
Breaking Biology News(10 mins):Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Latin America Biomedical Sensors Market Report 2015-2020 2TAKE Solutions Awarded Patent By USPTO 2
... have found a way to pull pure oxygen from ... and a room-temperature glass of water. ,Because oxygen ... using solar electricity to split water into those elements--a ... One of the chief obstacles to that green-energy scenario ...
... United States, Lyme disease is the most frequently reported ... These animal-borne diseases can make people very sick, and ... crucial to protecting the public. Scientists at the Cary ... $750,000 in grant funding from the U.S. Environmental Protection ...
... University of New Hampshire researchers have tagged one ... They are the first free-swimming leatherbacks ever tagged in ... an endangered species, were tagged July 17, 26 and ... tracking data, allowing scientists to better understand these elusive, ...
Cached Biology News:Water refineries? 2Water refineries? 3EPA funds ground-breaking Lyme disease research 2UNH researchers tag first-ever free-swimming leatherback turtles in New England 2UNH researchers tag first-ever free-swimming leatherback turtles in New England 3
(Date:7/27/2015)... ... July 27, 2015 , ... Production of high tenacity filament yarn of ... in the EU. For instance, it surpassed the EUR 106 million mark (in value ... 2010. Germany is a major producer, while Italy is a key consumer. , ...
(Date:7/27/2015)... -- Research presented at the 2015 AACC Annual Meeting ... that led to a fingerprick Ebola test becoming the ... receive approval from the World Health Organization (WHO). This ... West Africa by identifying suspected ... isolate and treat these patients much faster than is ...
(Date:7/27/2015)... YORK , July 27, 2015 ... today announced the winners of its annual Klerman ... research by scientists who have been supported by ... career scientists to pursue innovative ideas in neurobiological ... "proof" of concept for the early detection, treatment, ...
(Date:7/27/2015)... ... 27, 2015 , ... Visual Assay was named as a finalist for the ... technologies and services of the past year. More than 70 judges selected the finalists, ... will be announced at the 2015 R&D 100 Awards Dinner on November 13 at ...
Breaking Biology Technology:High Tenacity Filament Yarn of Viscose Rayon Consumption to Grow Swiftly in the EU, Forecasts BAC Reports in New Study Available at MarketPublishers.com 2Rapid Ebola Test Could Play Key Role in Efforts to End Lingering Outbreak 2Rapid Ebola Test Could Play Key Role in Efforts to End Lingering Outbreak 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 4Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 5Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 6Visual Assay® Named Finalist in 53rd Annual R&D 100 Awards 2
... ITMN ) today announced that Daniel G. Welch, Chairman, ... Deutsche,Bank,s 2008 Biotech Boston Confab on November 11, 2008 ... audio webcast of the presentation, investors and other,interested parties ... InterMune,s,corporate website at http://www.intermune.com . The company recommends,logging ...
... Human Genome Sciences,Inc. (Nasdaq: HGSI ) announced ... Confab will be webcast and may be accessed at, ... A member of Human Genome Sciences, senior management team ... at 2:50 PM Eastern Time., Investors interested in ...
... that its executives will be speaking at the following,investor conferences, and ... Credit Suisse Global Health Care Conference, Phoenix, AZ ... Time, Piper Jaffray Health Care Conference, ... 2008 at 2.00 p.m. Eastern Time Accessing Webcasts, To ...
Cached Biology Technology:Cepheid to Webcast Upcoming Financial Presentations 2
Enables rapid purification of double-stranded DNA fragments = 200 bp, including, for example, PCR reaction products, DNA fragments obtained in restriction enzyme digests, or double-stranded cDNA...
Silica bead method is an economic method of DNA extraction from agarose...
5 minutes from gel band to purified DNA...
BD IMag Anti-Mouse CD90.2 (Thy1.2) Particles-MSC 2 x 109 cells...
Biology Products: