Navigation Links
One gene, many mutations
Date:3/14/2013

For deer mice living in the Nebraska Sandhills, color can literally be the difference between life and death.

When they first colonized the region, the dark-coated mice stood out starkly against the light-colored, sandy soil, making them easy prey for predators. Over the next 8,000 years, however, the mice evolved a new system of camouflage lighter coats, changes in the stripe on their tails and changes in the extent of pigment across their body that allowed them to blend into their new habitat.

Now Harvard researchers are using their example to answer one of the fundamental questions about evolution - is it a process marked by large leaps single mutations that result in dramatic change in an organism or is it the result of many smaller changes that accumulate over time?

As described in a March 15 paper in Science, a team of researchers, including former Postdoctoral Fellow Catherine Linnen, now an Assistant Professor at the University of Kentucky, and led by Professor of Organismic and Evolutionary Biology and Molecular and Cellular Biology Hopi Hoekstra, were able to show that the changes in mouse coat color were the result not of a single mutation, but at least nine separate mutations all within a single gene.

"The findings demonstrate how the cumulative effect of natural selection, acting on many small genetic changes, can produce rapid and dramatic change," Linnen, the first author of the paper, said. "This helps us to understand, from a genetic perspective, the uncanny fit between so many organisms and their environmentsby acting on many small changes, rather than a handful of large ones, natural selection can produce very finely honed adaptations."

Surprisingly, Hoekstra said, that honing occurred in a single gene.

The role of this gene, called agouti, in camouflage was first discovered by Linnen, Hoekstra and colleagues in 2009, and it is responsible for changes in pigmentation in th
'/>"/>

Contact: Peter Reuell
preuell@fas.harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. BRG1 mutations confer resistance to hormones in lung cancer
2. Gene mutations cause massive brain asymmetry
3. Interacting mutations promote diversity
4. Mutations in autism susceptibility gene increase risk in boys
5. UMMS researchers isolate gene mutations in patients with inherited amyotrophic lateral sclerosis
6. New gene mutations linked to ALS and nerve cell growth dysfunction
7. Key mutations discovered for most common childhood brain cancer
8. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
9. Gene mutations linked to most cases of rare disorder -- Alternating Hemoplegia of Childhood
10. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
11. Populations survive despite many deleterious mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... to their resumes in an effort to aid the ... issues as genomic science transitions to bedside healthcare, a ... , Until now the plays of Karen H. Rothenberg ... by, their peers and others in the genomics community ... Oxford University Press, publication of the book The ...
(Date:4/23/2014)... Indiana University School of Public Health-Bloomington has bolstered the ... finding a strong association between heme iron, found only ... The study found that heme iron consumption increased the ... no association was found between nonheme iron, which is ... disease. , The study was published online ahead of ...
(Date:4/23/2014)... that male black widow spiders prefer their female mates ... mate preference by male spiders. , The ... Andrade, a professor in UTSC,s Department of Biological Sciences, ... that males overwhelmingly chose to mate with well-fed, unmated ... whether a potential mate is well-fed and unmated by ...
Breaking Biology News(10 mins):Bioethicists use theatrical narratives to bridge the gap between society and science 2Bioethicists use theatrical narratives to bridge the gap between society and science 3Study: Iron consumption can increase risk for heart disease 2Picky male black widow spiders prefer well-fed virgins 2
... benefit from treatment with mixtures of customized antibodies. In ... National Academy of Sciences (USA), a team of Weizmann ... form a web that destroys the cancer cell's communication ... intensive cancer research led to the identification of a ...
... seem to occur on Earth roughly every 26 million ... be caused by rare collisions with comets or asteroids. ... that extraordinary predators are at fault instead. , Adam ... many species competing for both food and living space. ...
... to accurately measure the levels of important chemicals in ... level of a single cell. Scientists at the Carnegie ... the first to overcome this obstacle by successfully applying ... brain chemical levels. The sensors alter their 3-dimensional form ...
Cached Biology News:Two are better than one 2Revolutionary nanotechnology illuminates brain cells at work 2Revolutionary nanotechnology illuminates brain cells at work 3
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how latent viruses ... is the Epstein Barr Virus (EBV), and one of these ... chronic inflammatory disease that destroys the body’s joints. As predicted ... high concentrations of EBV DNA in their bodies (1). ...
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
(Date:1/14/2014)... 14, 2014 Histogen, Inc., a regenerative ... cells grown under simulated embryonic conditions, today announced that ... Suneva Medical, Inc. for physician-dispensed aesthetic products containing Histogen’s ... This agreement is an amendment to the existing license ...
(Date:1/14/2014)... Jan. 14, 2014 The largest international professional ... plants and therapeutic derivatives thereof has endorsed an ... researchers about the challenges of adulterated herb and ... The Society for Medicinal Plant ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8
... 21, 2011 Cephalon, Inc. (NASDAQ: CEPH ... Consent Revocation Statement with the Securities and Exchange Commission ... proposals to remove Cephalon,s entire Board of Directors and ... mailed copies of the Statement to shareholders of record ...
... Collins Stewart LLC is pleased to announce the ... Beal Advisors and Liberty Tree Advisors. The purpose of ... and private equity transactions in the healthcare sector. Both ... healthcare advisory firms. Georgia Erbez – founder of Beal ...
... Calif., April 21, 2011 The Stanford University ... the initiation of a Phase 1/2a clinical trial ... allogeneic cell therapy product, SB623, on patients suffering ... For details regarding this clinical trial, please refer ...
Cached Biology Technology:Cephalon Files Definitive Consent Revocation Statement, Commences Mailing to Shareholders 2Cephalon Files Definitive Consent Revocation Statement, Commences Mailing to Shareholders 3Cephalon Files Definitive Consent Revocation Statement, Commences Mailing to Shareholders 4Cephalon Files Definitive Consent Revocation Statement, Commences Mailing to Shareholders 5Cephalon Files Definitive Consent Revocation Statement, Commences Mailing to Shareholders 6Cephalon Files Definitive Consent Revocation Statement, Commences Mailing to Shareholders 7Cephalon Files Definitive Consent Revocation Statement, Commences Mailing to Shareholders 8Cephalon Files Definitive Consent Revocation Statement, Commences Mailing to Shareholders 9Cephalon Files Definitive Consent Revocation Statement, Commences Mailing to Shareholders 10Collins Stewart Announces Formation of Healthcare Investment Banking Alliance 2Collins Stewart Announces Formation of Healthcare Investment Banking Alliance 3Stanford and SanBio Announce a Clinical Trial of Cell Therapy for Stroke Disability 2