Navigation Links
One gene, many mutations
Date:3/14/2013

For deer mice living in the Nebraska Sandhills, color can literally be the difference between life and death.

When they first colonized the region, the dark-coated mice stood out starkly against the light-colored, sandy soil, making them easy prey for predators. Over the next 8,000 years, however, the mice evolved a new system of camouflage lighter coats, changes in the stripe on their tails and changes in the extent of pigment across their body that allowed them to blend into their new habitat.

Now Harvard researchers are using their example to answer one of the fundamental questions about evolution - is it a process marked by large leaps single mutations that result in dramatic change in an organism or is it the result of many smaller changes that accumulate over time?

As described in a March 15 paper in Science, a team of researchers, including former Postdoctoral Fellow Catherine Linnen, now an Assistant Professor at the University of Kentucky, and led by Professor of Organismic and Evolutionary Biology and Molecular and Cellular Biology Hopi Hoekstra, were able to show that the changes in mouse coat color were the result not of a single mutation, but at least nine separate mutations all within a single gene.

"The findings demonstrate how the cumulative effect of natural selection, acting on many small genetic changes, can produce rapid and dramatic change," Linnen, the first author of the paper, said. "This helps us to understand, from a genetic perspective, the uncanny fit between so many organisms and their environmentsby acting on many small changes, rather than a handful of large ones, natural selection can produce very finely honed adaptations."

Surprisingly, Hoekstra said, that honing occurred in a single gene.

The role of this gene, called agouti, in camouflage was first discovered by Linnen, Hoekstra and colleagues in 2009, and it is responsible for changes in pigmentation in th
'/>"/>

Contact: Peter Reuell
preuell@fas.harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. BRG1 mutations confer resistance to hormones in lung cancer
2. Gene mutations cause massive brain asymmetry
3. Interacting mutations promote diversity
4. Mutations in autism susceptibility gene increase risk in boys
5. UMMS researchers isolate gene mutations in patients with inherited amyotrophic lateral sclerosis
6. New gene mutations linked to ALS and nerve cell growth dysfunction
7. Key mutations discovered for most common childhood brain cancer
8. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
9. Gene mutations linked to most cases of rare disorder -- Alternating Hemoplegia of Childhood
10. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
11. Populations survive despite many deleterious mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2015)... Aware, Inc. (NASDAQ: AWRE ), a leading ... for its second quarter ended June 30, 2015.  ... million, a decrease of 33% compared to $6.8 million in ... quarter of 2015 was $0.3 million, or $0.01 per diluted ... share, in the same period a year ago.  ...
(Date:7/21/2015)... July 21, 2015 Passwords have proven ... in the recent U.S. Office of Personnel Management ... the infosec conundrum, but developers and end-users are ... address this dilemma, Biometrics-as-a-Service provider HYPR Corp. announced ... SDK for third party integration. ...
(Date:7/9/2015)... Calif. , July 9, 2015  Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... Thursday, July 30, 2015 after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
Breaking Biology News(10 mins):Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2
... WASHINGTONA single, huge, violent storm that swept across the ... a new study shows. While storms have long ... study is the first to produce an actual body count. ... study,s authors say. This suggests that storms may play a ...
... world championship if we couldn,t distinguish the ball from its ... if your favourite team,s striker could see the movements of ... to flies. The minute brains of these aeronautic acrobats process ... the brain of the fly manages to perceive motion with ...
... 2010 Are online learning modules beneficial to educational ... learning modules to help increase participant understanding of key ... researchers found that participants both visited the sites on ... knowledge. Researchers at the University of Arizona, led ...
Cached Biology News:Staggering tree loss from 2005 Amazon storm 2Staggering tree loss from 2005 Amazon storm 3Staggering tree loss from 2005 Amazon storm 4The brain of the fly -- a high-speed computer 2The brain of the fly -- a high-speed computer 3The brain of the fly -- a high-speed computer 4Online learning supplements watershed program 2
(Date:7/30/2015)... ... July 30, 2015 , ... Leading regenerative ... study of its canine osteoarthritis stem cell product, currently under development for FDA ... and will be marketed in the US by Aratana. This product, termed AT-016, ...
(Date:7/30/2015)... , July 30, 2015  With over 60,000 customers across the globe, ISN improves ... 450 hiring organizations with more than 60,000 safe and reliable contractors in over 80 countries. ... ... Over ... Headquartered in Dallas, TX ...
(Date:7/30/2015)... , July 30, 2015  Discovery Laboratories, Inc. ... has received the second $1.0M tranche under a ... (SBIR) grant valued at up to $3.0 million ... KL4 surfactant as a potential medical countermeasure to ... Labs was awarded an initial $1.0 million under ...
(Date:7/29/2015)... PARIS , July 30, 2015 ... leader, reports results for the second quarter of ... the group,s results and its performance in different ... transcript:  http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire ... - Q2 results - Performance drivers ...
Breaking Biology Technology:VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... Novavax, Inc. (Nasdaq: NVAX ) today announced ... a press release to be issued after 8:00 a.m. local ... investor conference call at 10:00 a.m. The call will be ... Singhvi and other members of senior management. The dial-in number ...
... NEW YORK, March 23, 2011 ... ACCP ), a biopharmaceutical company leveraging its ... oncology, cancer supportive care and diabetes, has ... Care and Market Access.  A 16-year industry veteran, Mottola ...
... made of carbon nanotubes dipped in a polymer solution equal ... cells, a team of Case Western Reserve University engineers has ... to boost the power output and maintain the other advantages ... But already they,ve proved the simple technique can knock ...
Cached Biology Technology:Access Pharmaceuticals Appoints Industry Executive Anthony Mottola as Vice President of Managed Care and Market Access 2Access Pharmaceuticals Appoints Industry Executive Anthony Mottola as Vice President of Managed Care and Market Access 3Cheap catalyst made easy 2
Plasmid expressing Zeocin resistance gene....
...
Hygromycin resistance gene (hph), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
... FRT-PGK-gb2-neo-FRT template is designed to allow ... The FRT-PGK-gb2-neo-FRT template encodes the neomycin/kanamycin ... (gb2) for expression of kanamycin resistance in ... (PGK) for expression of neomycin resistance in ...
Biology Products: