Navigation Links
Oncolytics Biotech, Inc. announces publication of research
Date:1/7/2008

CALGARY, AB, January 7, 2008 -- Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ONCY) (Oncolytics) reported today that a research group led by Dr. Richard Vile of the Mayo Clinic College of Medicine in Rochester, Minnesota, published the results of its work testing the antitumor efficacy and safety of various combinations of reovirus and cyclophosphamide in vivo. The paper, entitled Cyclophosphamide Facilitates Antitumor Efficacy against Subcutaneous Tumors following Intravenous Delivery of Reovirus appears online in the January 1, 2008 issue of Clinical Cancer Research.

This exciting Mayo Clinic work supported the initiation of our combination REOLYSIN and cyclophosphamide clinical trial, recently approved by the U.K. health authorities, said Dr. Matt Coffey, Chief Scientific Officer of Oncolytics.

The purpose of the research study was to investigate whether it was possible to use cyclophosphamide, an immune modulator, to enhance the delivery and replication of the reovirus when delivered intravenously. After testing various doses and dosing regimens of reovirus and cyclophosphamide in mice, a metronomic dosing regimen was developed that resulted in increased survival, high levels of reovirus recovered from regressing tumors, levels of neutralizing antibodies that were protective, and only very mild toxicities. The data support investigation in human clinical trials of the use of cyclophosphamide prior to systemic reovirus administration to modulate, but not ablate, the immune system.


'/>"/>

Contact: Cathy Ward
cathy.ward@oncolytics.ca
403-670-7377
Oncolytics Biotech Inc.
Source:Eurekalert

0

GOOD

Page: 1

Related biology news :

1. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
2. LaserCard Corporation Announces Expansion of Middle East Project
3. BIO-key(R) Announces Contracts for New Criminal Justice Data Sharing Solution
4. Balzan Foundation announces 2007 winners
5. The American Society of Plant Biologists announces 2007 awards
6. ASPB announces Summer Undergraduate Research Fellowship 2007 recipients
7. NIST announces 56 new awards for innovative technology research and development
8. Titanium Group Announces Contract With Haitong Securities
9. Measurement Specialties, Inc. Announces Impact of German Business Tax Reform 2008 Resulting in Lower Combined German Tax Rate - Impacts 2Q08 Reported Financial Results
10. FIJI Water announces sustainable growth initiative with commitment to help mitigate climate change
11. HGS announces positive Phase 2 LymphoStat-B at ACR meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... cellular layer lining the body,s blood vessels, is ... in thickness, this super-tenuous structure routinely withstands blood ... create a unique and highly dynamic barrier that ... the body,s circulatory system. , It,s also extremely ... physically breached to enable immune cells to ...
(Date:5/16/2013)... fossils that are about 23 million years old ... the gobioid order, one of the most species-rich ... led by paleontologist Professor Bettina Reichenbacher from the ... of Earth and Environmental Sciences at Ludwig-Maximilians-Universitaet (LMU) ... analysis of fish fossils which they assign to ...
(Date:5/16/2013)... of us don,t ponder our pulses outside of the gym. ... to monitor heart health. , Zhenan Bao, a professor of ... than a dollar bill and no wider than a postage ... on the wrist, is sensitive enough to help doctors detect ... day be used to continuously track heart health and provide ...
Breaking Biology News(10 mins):Endothelium, heal thyself 2Endothelium, heal thyself 3Endothelium, heal thyself 4Paleontology: The eloquence of the otoliths 2Paleontology: The eloquence of the otoliths 3Stanford engineers monitor heart health using paper-thin flexible 'skin' 2Stanford engineers monitor heart health using paper-thin flexible 'skin' 3
... collaborative projects that include the work of two different ... grace the covers of the journals Science and Nature ... Associate Dean of Science Christopher Raxworthy and colleagues analyzed ... keystone species, to determine a conservation plan for a ...
... evidence indicates the Grand Canyon may be so old that ... by researchers from the University of Colorado at Boulder and ... technique known as radiometric dating to show the Grand Canyon ... back its assumed origins by 40 million to 50 million ...
... study mapping the evolutionary history of animals indicates that ... be inferred from fossils and studies of living animals--was ... The study, which was funded by the National Science ... 10, 2008 issue of Nature. Using new high-powered technologies ...
Cached Biology News:AMNH scientists grace Science & Nature covers 2AMNH scientists grace Science & Nature covers 3Grand Canyon may be as old as dinosaurs, says new study 2Grand Canyon may be as old as dinosaurs, says new study 3And the first animal on Earth was a... 2And the first animal on Earth was a... 3
(Date:5/17/2013)... RESEARCH TRIANGLE PARK, N.C., USA (PRWEB) May 17, 2013 ...     Green Globes Certified for sustainability , ... drought and insect pressures , Syngenta ... grand opening celebration today at the company’s RTP Innovation ... Crop Lab allows company researchers to simulate any agricultural ...
(Date:5/17/2013)...  Insero Health, Inc., a company developing natural compounds ... neurological disorders, is today reporting top-line results from a ... patients with drug-resistant epilepsy.  The data are being presented ... meeting by Dr. Steven Schachter , ... Advisory Board.  In this study, INS001 appeared safe and ...
(Date:5/17/2013)... (PRWEB) May 17, 2013 IAC Industries wants ... a start up laboratory needing to set up and furnish ... to a larger facility within a year’s time. How does ... that the laboratory is temporary? What is efficient and cost-effective? ... modular workstations from IAC Industries. The planners at DisperSol determined ...
(Date:5/16/2013)... New Zealand (PRWEB) May 16, 2013 In ... was invited to speak to doctors in China about ... Australia and NZ, this was her first trip to lecture ... Dr. Hart visited Guangzhou and Fuzhou, home to 12 and ... in China is very high at this point in time. ...
Breaking Biology Technology:Syngenta Opens Unique $72 Million Advanced Crop Lab 2Syngenta Opens Unique $72 Million Advanced Crop Lab 3Insero Health Reports Positive Data on Phase I Trial of Novel Therapy for Drug-resistant Epilepsy 2New Downloadable Success Story: “How To Outfit a Dynamic Lab in Flux” 2
... Cell Therapeutics, Inc. (CTI),(Nasdaq: CTIC ; MTAX) management will present at the ... in the West Foyer,of the Waldorf-Astoria Hotel., The presentation will also be ... be accessed at, http://www.cticseattle.com ., , ... BIO CEO & Investor Conference ...
... of helping scientists and clinicians understand life one cell at a ... ... time, HAYWARD, Calif., Feb. 6 This year marks 10 ... to the lab benches of thousands of,scientists and clinicians worldwide. Since ...
... Feb. 5 Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ) ... Annual,BIO CEO and Investor Conference on Tuesday, February 12, ... is being held at the Waldorf-Astoria,Hotel in New York., ... of Anadys,Pharmaceuticals, Inc., will present an overview of Anadys ...
Cached Biology Technology:Guava Technologies Celebrates Tenth Anniversary 2Anadys Pharmaceuticals to Present at the BIO CEO & Investor Conference 2
Request Info...
Assay Kit formatted for flow cytometric detection of levels of phosphorylated histone H2A.X....
Request Info...
... system. For real-time or pre-programmed liquid ... or general liquid-handling research applications. >UL> ... Run experiments automatically - even ... flexibility Turnkey perfusion system includes ...
Biology Products: