Navigation Links
Oncolytic virus extends survival in medulloblastoma model
Date:2/15/2012

  • Medulloblastoma is the most common malignant brain tumor in children.
  • Disseminated medulloblastoma is particularly lethal and requires extensive radiation therapy to the brain, which can cause brain damage.
  • An oncolytic measles virus has shown effectiveness in a new model of disseminated human medulloblastoma.

COLUMBUS, Ohio A strain of measles virus engineered to kill cancer cells prolongs survival in a model of medulloblastoma that is disseminated in the fluid around the brain, according to a new study by researchers at Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and the Mayo Clinic. Treatment with the oncolytic virus called MV-GFP extended survival of animals with disseminated human medulloblastoma up to 122 percent, with treated animals surviving 82 days on average versus 37 days for controls. Two of the eight treated animals were left cancer-free.

The findings, published online in the journal Neuro-Oncology, could lead to a safer, more effective therapy for medulloblastoma, and particularly for disseminated medulloblastoma, the researchers say.

Medulloblastoma accounts for 15 to 20 percent of all childhood brain tumors, with 350 to 400 new cases diagnosed annually in the United States.

Untreated, medulloblastoma is fatal. Current therapy for the disease involves surgery, multidrug chemotherapy and radiation therapy to the entire brain. Five-year survival is about 60 percent, but the extensive radiation therapy often leads to decreased intelligence.

Furthermore, in about 20 percent of newly diagnosed patients and 75 percent of patients with recurrent disease, the tumor has disseminated into the cerebrospinal fluid. Five-year survival for these children is less than 20 percent.

"Patients whose tumor has spread into the fluid around the brain and spinal cord have an especially grim prognosis," says principal inves
'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Immunological mechanisms of oncolytic adenoviral therapy
2. Deadly rugby virus spreads in sumo wrestlers
3. Structures of important plant viruses determined
4. Research about plant viruses could lead to new ways to improve crop yields
5. World leaders in infectious diseases convene to discuss emerging global viruses
6. Study: Bird diversity lessens human exposure to West Nile Virus
7. Scripps research team solves structure of beneficial virus
8. Tick-borne encephalitis virus reveals its access code
9. Protein tubules free avian flu virus from immune recognition
10. Forced evolution: Can we mutate viruses to death?
11. Nature Medicine study shows Peregrines bavituximab can cure lethal virus infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... an unexpected extent. The outbreak does not follow the ... a new disease dynamic in regions, where it has ... National Academy of Sciences Leopoldina, acatech – the German ... the German Academies of Sciences and Humanities have presented ... the statement the academies call for the following consequences ...
(Date:10/15/2014)... VILNIUS, Lithuania , Oct. 15, 2014 /PRNewswire/ ... identification technologies, today announced the availability of the ... . VeriLook Surveillance 3.0 provides real-time biometric face ... multiple high-resolution digital surveillance cameras. The new version ... detects and differentiates people from objects while they ...
(Date:10/14/2014)... fly genome for the first time, revealing robust immune ... thrives in pathogen-rich dung piles and garbage heaps. , ... Genome Biology , will increase understanding of house fly ... to resist insecticides, which could lead to novel control ... transmit more than 100 human and animal diseases, including ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2
... Theres more to biofuels than the food vs. fuel debate ... And so Steven Fales, a professor of agronomy ... Iowa States Bioeconomy Institute, organized and moderated a three-hour symposium ... American Association for the Advancement of Science in Boston. ...
... theory into practice to manage complex and closely linked ... challenge, but one NOAA researcher Anne Guerry says can ... value of our ocean resources. Guerry will ... people obtain from ecosystems, in managing marine resources in ...
... This release is available in French . , ... the University of Toronto to rev up the production of stem ... cells and embryonic stem cells. The end products are blood and ... they form beating tissue. To do this, he has ...
Cached Biology News:Iowa Staters talk biofuels, healthy oils and 'pharma crops' at AAAS meeting 2Can Dungeness crab and eelgrass help improve management of our marine resources? 2From stem cells to organs: The bioengineering challenge 2
(Date:10/22/2014)... According to new market research report "Cloud ... Deployment & Support), by Service Model (SaaS, PaaS, ... (Hybrid & Community)) - Global Forecast to 2019", ... Professional Services Market into various sub-segments with an ... identifies the drivers and restraints for this market ...
(Date:10/22/2014)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... Oral Amphotericin B program.  The company recently announced ... work involving samples from HIV/AIDS patients exposed to ... clinical studies and regulatory filings to move forward ... approximately $700,000 of funding and technological advice from ...
(Date:10/22/2014)... DUBLIN , Oct. 22, 2014 ... "Organic Electronics Market by Material, by Application, Geography ... report to their offering. Organic electronics, ... a branch of material science which deals with small ... as organic because small molecules and polymers are carbon ...
(Date:10/20/2014)... 20, 2014 The report “Pharmacy ... Systems, Packaging and Labeling Systems, Table-top Counters) by ... Global Forecasts & Trends to 2019” analyzes and ... in North America, Europe, Asia-Pacific, and the Rest ... tables and 30 figures spread through 300 pages ...
Breaking Biology Technology:Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4
... DIEGO, Jan. 25 NuVasive, Inc. (Nasdaq:,NUVA), a medical ... treatments for the spine, announced today,details relating to its ... take place on Tuesday, February 19, 2008, after,the close ... call on Tuesday, February 19, 2008 at,5:30 p.m. ET ...
... Part of Massive Rebuilding Effort for Tornado-Torn ... Health ... Sumter Regional,Hospital,s struggle to rebuild following a devastating 2007 tornado,Siemens has ... the Americus, Ga. facility with a new MAGNETOM ESSENZA, worth,approximately $800,000., ...
... Health Card Systems, Inc. (Nasdaq: NMHC ), a ... will host a,conference call on Friday, February 8th at ... 2008 fiscal second quarter. NMHC intends to,issue its quarterly ... February 7th., To participate in the live conference ...
Cached Biology Technology:NuVasive Announces Webcast and Conference Call of Fourth Quarter and Full Year 2007 Results 2NuVasive Announces Webcast and Conference Call of Fourth Quarter and Full Year 2007 Results 3A Magnetic Gift: Sumter Regional Hospital Receives New MRI as Charitable Donation From Siemens 2NMHC to Host Fiscal Second Quarter 2008 Conference Call 2
Rat Aortic Endothelial Cells (RAOEC) (>500,000 cells)...
... a compact, versatile & modular instrument which can ... Intracellular, Extracellular, Transducer & Multi-channel Isolated Amplification ... & Power Supply unit (NL900D) forms the heart ... only powered by this unit, but wiring within ...
anti-Yan 8B12H9...
...
Biology Products: