Navigation Links
Oncolytic virus extends survival in medulloblastoma model
Date:2/15/2012

  • Medulloblastoma is the most common malignant brain tumor in children.
  • Disseminated medulloblastoma is particularly lethal and requires extensive radiation therapy to the brain, which can cause brain damage.
  • An oncolytic measles virus has shown effectiveness in a new model of disseminated human medulloblastoma.

COLUMBUS, Ohio A strain of measles virus engineered to kill cancer cells prolongs survival in a model of medulloblastoma that is disseminated in the fluid around the brain, according to a new study by researchers at Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and the Mayo Clinic. Treatment with the oncolytic virus called MV-GFP extended survival of animals with disseminated human medulloblastoma up to 122 percent, with treated animals surviving 82 days on average versus 37 days for controls. Two of the eight treated animals were left cancer-free.

The findings, published online in the journal Neuro-Oncology, could lead to a safer, more effective therapy for medulloblastoma, and particularly for disseminated medulloblastoma, the researchers say.

Medulloblastoma accounts for 15 to 20 percent of all childhood brain tumors, with 350 to 400 new cases diagnosed annually in the United States.

Untreated, medulloblastoma is fatal. Current therapy for the disease involves surgery, multidrug chemotherapy and radiation therapy to the entire brain. Five-year survival is about 60 percent, but the extensive radiation therapy often leads to decreased intelligence.

Furthermore, in about 20 percent of newly diagnosed patients and 75 percent of patients with recurrent disease, the tumor has disseminated into the cerebrospinal fluid. Five-year survival for these children is less than 20 percent.

"Patients whose tumor has spread into the fluid around the brain and spinal cord have an especially grim prognosis," says principal investigator Dr. Cory Raffel, professor and vice-chair of neurological surgery.

"Because dissemination of tumor carries a grave prognosis, any treatment that can effectively treat this condition while avoiding radiation therapy could potentially improve survival in these patients and quality of life for survivors."

For this study, Raffel and his collaborators used two human medulloblastoma cell lines that they labeled with firefly luciferase, making the cells bioluminescent and enabling the researchers to track them as they dispersed in the living animal and responded to treatment with the oncolytic virus.

Three or 14 days after the cancer cells were implanted in the brain; the oncolytic virus was injected at the same location in five doses.

In the first medulloblastoma cell line tested, treated animals lived an average of 82 days compared with 37 days for the controls. Two of the eight animals were cured of the disseminated disease, which was determined first according to bioluminescent imaging, then histologically.

In a second experiment using a more virulent human medulloblastoma cell line, treated animals survived 37 days versus 16 days for controls, with one animal left cancer free.

Currently, the investigators are conducting studies to determine optimal dosing of the virus in preparation for a phase I clinical trial in humans.


'/>"/>
Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related biology news :

1. Immunological mechanisms of oncolytic adenoviral therapy
2. Deadly rugby virus spreads in sumo wrestlers
3. Structures of important plant viruses determined
4. Research about plant viruses could lead to new ways to improve crop yields
5. World leaders in infectious diseases convene to discuss emerging global viruses
6. Study: Bird diversity lessens human exposure to West Nile Virus
7. Scripps research team solves structure of beneficial virus
8. Tick-borne encephalitis virus reveals its access code
9. Protein tubules free avian flu virus from immune recognition
10. Forced evolution: Can we mutate viruses to death?
11. Nature Medicine study shows Peregrines bavituximab can cure lethal virus infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition and ... Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the market ... CAGR of 29.63% between 2017 and 2022. Continue ... ... ...
(Date:3/22/2017)... , March 21, 2017 Vigilant ... company serving law enforcement agencies, announced today the appointment ... as director of public safety business development. ... law enforcement experience, including a focus on the aviation ... his most recent position, Mr. Sheridan served as the ...
(Date:3/13/2017)... HAMBURG, Germany , March 13, 2017 Future of ... ... DERMALOGs Face Matching enables to match ... characteristics forms the basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... ... May 24, 2017 , ... ... treasurer for the Mid-Atlantic chapter of the Healthcare Businesswomen’s Association (HBA). ... The HBA Mid-Atlantic chapter board meets in person once each quarter and holds ...
(Date:5/24/2017)... As Ebola resurfaces in the Democratic ... suspected cases now reported, a new analysis of the Ebola ... correlation between the 2014 and 2017 outbreaks of the disease.  ... 2012-13, which preceded the 2014 outbreak. An analysis of the ... counts in 2014-15, which again precedes the current outbreak in ...
(Date:5/23/2017)... ... May 22, 2017 , ... NetDimensions ... in the Aragon Research Globe™ for Corporate Learning, 2017. , Aragon Research defines ... market demand, and effectively perform against those strategies. NetDimensions’ ranking as a Leader ...
(Date:5/23/2017)... ... May 23, 2017 , ... Bacterial biofilms, surface adherent communities of bacteria that ... ranging from food poisoning and catheter infections to gum disease and the rejection of ... billions of dollars per year, there is currently a paucity of means for preventing ...
Breaking Biology Technology: