Navigation Links
Oncolytic virus extends survival in medulloblastoma model
Date:2/15/2012

  • Medulloblastoma is the most common malignant brain tumor in children.
  • Disseminated medulloblastoma is particularly lethal and requires extensive radiation therapy to the brain, which can cause brain damage.
  • An oncolytic measles virus has shown effectiveness in a new model of disseminated human medulloblastoma.

COLUMBUS, Ohio A strain of measles virus engineered to kill cancer cells prolongs survival in a model of medulloblastoma that is disseminated in the fluid around the brain, according to a new study by researchers at Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and the Mayo Clinic. Treatment with the oncolytic virus called MV-GFP extended survival of animals with disseminated human medulloblastoma up to 122 percent, with treated animals surviving 82 days on average versus 37 days for controls. Two of the eight treated animals were left cancer-free.

The findings, published online in the journal Neuro-Oncology, could lead to a safer, more effective therapy for medulloblastoma, and particularly for disseminated medulloblastoma, the researchers say.

Medulloblastoma accounts for 15 to 20 percent of all childhood brain tumors, with 350 to 400 new cases diagnosed annually in the United States.

Untreated, medulloblastoma is fatal. Current therapy for the disease involves surgery, multidrug chemotherapy and radiation therapy to the entire brain. Five-year survival is about 60 percent, but the extensive radiation therapy often leads to decreased intelligence.

Furthermore, in about 20 percent of newly diagnosed patients and 75 percent of patients with recurrent disease, the tumor has disseminated into the cerebrospinal fluid. Five-year survival for these children is less than 20 percent.

"Patients whose tumor has spread into the fluid around the brain and spinal cord have an especially grim prognosis," says principal inves
'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Immunological mechanisms of oncolytic adenoviral therapy
2. Deadly rugby virus spreads in sumo wrestlers
3. Structures of important plant viruses determined
4. Research about plant viruses could lead to new ways to improve crop yields
5. World leaders in infectious diseases convene to discuss emerging global viruses
6. Study: Bird diversity lessens human exposure to West Nile Virus
7. Scripps research team solves structure of beneficial virus
8. Tick-borne encephalitis virus reveals its access code
9. Protein tubules free avian flu virus from immune recognition
10. Forced evolution: Can we mutate viruses to death?
11. Nature Medicine study shows Peregrines bavituximab can cure lethal virus infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... Networking in personalized cancer medicine, (the WIN consortium), recently ... Thomas Jefferson University will be one of its ... prestigious group in the Tri-State Area. The goal of ... medicine to the patient by forging collaborations between partners ... in the WIN consortium means Jefferson cancer patients will ...
(Date:7/23/2014)... temperature around the world by 2050, according to one ... Climate Change (IPCC), may be advantageous to the physiology ... growth of forage plants such as Stylosanthes capitata ... tropical countries such as Brazil., The conclusion is from ... of Biology at the Ribeiro Preto Faculty of Philosophy, ...
(Date:7/23/2014)... HOLE, MA -- What do mollusks, starfish, and ... marine habitat, they are all calcifiersorganisms that use ... skeletons and shells for stability and protection. , ... , published by the Marine Biological Laboratory, addresses ... composition changes worldwide. , As atmospheric carbon dioxide ...
Breaking Biology News(10 mins):New partnership brings more personalized cancer treatment to Philadelphia 2An increase in temperature by 2050 may be advantageous to the growth of forage plants 2An increase in temperature by 2050 may be advantageous to the growth of forage plants 3An increase in temperature by 2050 may be advantageous to the growth of forage plants 4Calcification in changing oceans explored in special issue of The Biological Bulletin 2
... Fingerprints mark us out as individuals and leave telltale ... touch, but what are fingerprints really for? According to ... and tree-climbing koalas have fingerprints and some South American ... everyone presumed that fingerprints are there to help us ...
... in a remote region of the Russian mountains a previously ... discovered. Lead Scientist Professor Hans Cornelissen and his Russian-Dutch team ... The root belongs to the small alpine plant Corydalis conorhiza ... upward through layers of snow. Given this novel behaviour, the ...
... edition of the BBVA Foundation Frontiers of Knowledge ... under the presidency of the Spanish Minister of ... Foundation President, Francisco Gonzlez. The public at the ... scientific community and high-level government institutions alongside personalities ...
Cached Biology News:Urban myth disproved: Fingerprints do not improve grip friction 2Newly discovered snow roots are 'evolutionary phenomenon' 2The BBVA Foundation presents its Frontiers of Knowledge Awards 2
(Date:7/23/2014)... have made great strides in saving China,s endangered national ... over 65 giant panda reserves that have been established ... just 1596 pandas remain in the wild. , ... save the panda by improving genetic diversity, avoid inbreeding ... how are these high-profile programs doing so far? , ...
(Date:7/23/2014)... at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR), the Vienna University ... have succeeded in embedding nearly perfect semiconductor crystals ... of producing hybrid nanowires, very fast and multi-functional ... chip in the future. The research results will ... . , Nano-optoelectronics are considered the cornerstone of ...
(Date:7/23/2014)... , July 23, 2014  AuraSense Therapeutics, ... as gene regulatory and immunotherapeutic agents, announced ... joined AuraSense Therapeutics, executive leadership team as ... Prior to joining AuraSense Therapeutics, Mr. ... Financial Officer of Cellular Dynamics International Inc., ...
(Date:7/23/2014)... Last year, Formedix celebrated its partnership with ... data management solutions for clinical trials. The company launched ... data capture (EDC) and clinical data management. Formedix, a ... added TrialMaster to its Transform for EDC product line. ... TrialMaster, is being released this week, in response to ...
Breaking Biology Technology:A crystal wedding in the nanocosmos 2AuraSense Therapeutics Appoints Biotechnology Veteran David S. Snyder as Chief Financial Officer 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3
... PAREXEL International (NASDAQ: PRXL ), a ... H. von Rickenbach, Chairman and Chief Executive Officer of ... Massachusetts Biotechnology Council (MassBio) CRO/CMO Symposium , to ... Waltham, Massachusetts. The symposium, organized by the MassBio Contract ...
... Study results published today in the   New - ...   show that 3-year graft survival is significantly greater in all ...   Kidney Transporter compared to those stored in a traditional box ... [1]   The graft survival difference at three years was ...
... Graduate Institute (KGI) has been selected by the Council ... Foundation to administer the Professional Science Master,s (PSM) Affiliation ... quality standards for PSM programs across the country. ... look forward to providing leadership for this important degree ...
Cached Biology Technology:PAREXEL Chairman and CEO to Deliver Keynote at MassBio CRO/CMO Symposium 2PAREXEL Chairman and CEO to Deliver Keynote at MassBio CRO/CMO Symposium 3PAREXEL Chairman and CEO to Deliver Keynote at MassBio CRO/CMO Symposium 4PAREXEL Chairman and CEO to Deliver Keynote at MassBio CRO/CMO Symposium 5Machine Preservation Significantly Improves Kidney Transplant Survival Over 3 Years Compared to Traditional box of ice 2Machine Preservation Significantly Improves Kidney Transplant Survival Over 3 Years Compared to Traditional box of ice 3KGI Selected to Administer PSM Affiliation Process 2
Denhardt's Solution is a mixture of blocking agents used in membrane-based hybridization protocols. The solution contains 1% Ficoll (type 400) 1% polyvinylpyrrolidone and 1% bovine serum albumin. Ste...
... DW4 liquid handling system from Molecular Devices ... in one instrument. The system handles a ... plate washing96-, 384- and 1536-welland is the ... DW4 has been optimized to dispense from ...
... exist between the various commercial and lab-prepared ... used, the length and GC content of ... manufacturing protocol employed all influence the optimal ... With all the different variables to consider, ...
... ICS-1500 system provides excellent performance with ... electrolytic suppression, and column heater all ... outstanding sensitivity and stability. The vacuum ... for trace-level work. Operate in manual ...
Biology Products: