Navigation Links
Oncogene AEG-1 strongly predicts response to erlotinib treatment in EGFR-mutant lung cancer
Date:2/25/2011

Spanish researchers have identified a gene whose expression level strongly predicts how well certain lung cancer patients will respond to treatment with the drug erlotinib.

Dr Rafael Rosell and colleagues reported their findings at the European Multidisciplinary Conference in Thoracic Oncology (EMCTO), 24-26 February 2011 in Lugano, Switzerland.

The researchers studied 55 patients with non-small cell lung cancer, whose tumors had mutations in the epidermal growth factor receptor (EGFR) gene. All were being treated with the drug erlotinib, which acts on the EGFR molecule.

"Currently we have no predictors for the duration of response to EGFR drugs in non-small cell lung cancer patients with EGFR mutation," Dr Rosell explained. "The median progression-free survival time for these patients ranges from 10 to 14 months, but there is a subgroup of patients with very short response while others have long lasting benefit."

Researchers in the Spanish Lung Cancer Group (SLCG), in cooperation with Pangaea Biotech, USP Dexeus University Institute, Barcelona -- which acts as one of the reference laboratories for the SLCG -- set out to find genes that predicted which patients would have a lasting benefit, and which would not. To do this, they used a technology called NanoString. "NanoString is an integrated digital technology with high levels of precision and sensitivity that detects expression levels of hundreds of genes in a single reaction, making it suitable for clinical use," Dr Rosell explained.

Dr Rosell and colleagues used the technology to examine expression levels of 48 different genes in 43 patients with EGFR-mutant non-small cell lung cancer who were being treated with erlotinib.

They found that AEG (astrocye elevated gene 1, also known as metadherin) was the strongest predictor of progression-free survival in these patients. Progression-free survival was 27 months for those with low AEG-1 expression, compare
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
2. Doctors not strongly encouraging HPV vaccine to girls of certain age
3. New model predicts hot spots for mercury in fish
4. Pregnancy hormone predicts postpartum depression
5. Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer
6. Study predicts when invasive species can travel more readily by air
7. Blood test predicts chance of dementia
8. Computer model predicts brain tumor growth and evolution
9. NOAA forecast predicts large dead zone for Gulf of Mexico this summer
10. Gene predicts how brain responds to fatigue, human study shows
11. Blood-flow metabolism mismatch predicts pancreatic tumor aggressiveness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)...  When it comes to technology, healthcare is usually one of ... However, when it comes to wearables, healthcare is trying to move ... Internet of Things and its wearable cousins is less than mature, ... industry, whether it,s in the hospital for a major procedure or ... With that in mind, InformationWeek editor Rodney Brown ...
(Date:7/29/2014)... has received from the National Institutes of Health ... project to support the further development of 23andMe,s ... , Specifically, the grant supports four areas ... to improve the company,s ability to identify novel ... to support the collection of a broader set ...
(Date:7/29/2014)... is a rare disease it affects 1 in 100,000 ... the esophageal wall. While its cause remains unknown, a new ... Belgium, the University of Bonn in Germany and other European ... in origin. The study, published on 6 July in ... mysterious disease. , When we swallow, a sphincter in the ...
Breaking Biology News(10 mins):23andMe scientists receive approximately $1.4 million in funding from National Institutes of Health 223andMe scientists receive approximately $1.4 million in funding from National Institutes of Health 3Mysterious esophagus disease is autoimmune after all 2
... FL November 18, 2010 For Immediate Release - ... Palm Beach residents Judy and J. John Goodman, M.D., to ... Professor Thomas Kodadek, Ph.D., in the development of a new ... as the Scripps Research graduate program endowment. "We are ...
... Nov. 18, 2010 AMDeC, the Academy ... Technologies has renewed and expanded its agreement to offer ... on a number of products important for genomics and ... academic medical research institutions in the New York region. ...
... disorder characterized by progressive loss of vision that in ... stage. , In a ChIP-Seq based approach, the researchers ... Crx (Cone-rod homeobox) in the expression of retina-specific genes ... perception. In-depth analysis of Crx mediated regulation in photoreceptors ...
Cached Biology News:Agilent Technologies Expands Agreement to Offer AMDeC Members Preferential Pricing on Products Through AMDeC F.I.R.S.T.™ Vendor Partnership Program 2Agilent Technologies Expands Agreement to Offer AMDeC Members Preferential Pricing on Products Through AMDeC F.I.R.S.T.™ Vendor Partnership Program 3Transcription factor scan identifies genetic cause for inherited blindness 2
(Date:7/29/2014)... Calif. , July 29, 2014  ImmunoClin ... in personalized medicine, treatment of infectious diseases as ... of prognosis and prevention of pathologies like cardiovascular ... August 1, 2014, ImmunoClin Corporation will complete the ... Washington, D.C. , a key center ...
(Date:7/29/2014)... Hershey, PA & Rockville, MD (PRWEB) July 29, ... Immunomic Therapeutics, Inc. (ITI), a vaccine pioneer in ... the financial services firm Newport Coast Securities, Inc. ... , ITI is commercializing LAMP-vax technology, a breakthrough ... $25B+ vaccines and immunotherapy market. The company exclusively ...
(Date:7/29/2014)... Genera Energy Inc. , ... and supply chain advancements, has announced the deployment ... Grange™ and Supply ASSURE™. Both systems were ... aimed at consolidating and simplifying the entire process, ... and feedstock end users. , “Through the Energy ...
(Date:7/29/2014)... DisasterTalk is a texting app which allows ... masts or other transmitters are down. The app can transmit ... the need for any Wi-Fi, and can also use a ... app has launched as a housing report finds ... risk of being affected by natural disasters. With the risk ...
Breaking Biology Technology:ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3Immunomic Therapeutics Engages Newport Coast Securities, Inc. 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 3Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2
... Modern Mobility Aids, Inc. (OTCBB: MDRM) (the "Company") is ... required to execute its closing agreement to acquire all ... Modern Mobility Aids, Inc. is a Nevada-based ... development in the Bio-Pharma sector as well as scalable ...
... many polyhedral nanocrystals of silver can be packed into ... but the answer holds importance for one of today,s ... U.S. Department of Energy (DOE),s Lawrence Berkeley National Laboratory ... simpler approach for the fabrication of plasmonic materials by ...
... 22, 2011 SuperNova Diagnostics®, Inc., a privately-held global diagnostics ... Neil J. Campbell, President and CEO, will be presenting ... November 30, 2011 at 10:30 a.m. ET at the ... The presentation will include an overview of ...
Cached Biology Technology:Modern Mobility Aids, Inc. Secures Financing to Close Acquisition Agreement of LumiGene Technologies 2Modern Mobility Aids, Inc. Secures Financing to Close Acquisition Agreement of LumiGene Technologies 3On the road to plasmonics with silver polyhedral nanocrystals 2On the road to plasmonics with silver polyhedral nanocrystals 3SuperNova Diagnostics® to Present at the 23rd Annual Piper Jaffray Healthcare Conference in New York City 2
Image Analysis Software. PC Version of NIH Image....
... siRNA service provides the premium quality siRNAs ... Custom siRNAs can be readily ordered online ... sequence, or by providing the sense and ... Silencer Validated and Silencer Pre-designed siRNAs, which ...
MpV17 transgene, murine homolog, glomerulosclerosis...
Mouse monoclonal [6C3] to JAB1 ( Abpromise for all tested applications). entrezGeneID: 10987 SwissProtID: O15386...
Biology Products: