Navigation Links
On the trail of a targeted therapy for blood cancers
Date:10/10/2008

INDIANAPOLIS Investigators from the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine are focusing on a family of blood proteins that they hope holds a key to decreasing the toxic effects of chemotherapy in children and adults.

Their findings may one day help in the development of targeted therapies for leukemia, multiple myeloma and other cancers of the blood.

The researchers, led by Kristin T. Chun, Ph.D., assistant professor of pediatrics and of biochemistry and molecular biology, studied how the cullin family of proteins affects the degradation of proteins that control the development of blood cells. Their work was published in the July 15 issue of Blood, the journal of the American Society of Hematology.

The cullin family of proteins is involved in the degradation of proteins that control a myriad of cell functions, including those that determine whether a blood cell will eventually develop into a mature blood cell, will divide, or will undergo programmed cell death.

"How cullin 4A regulates other proteins that control the fate of blood cells is important because when cullin 4A fails to regulate their degradation properly, blood cells die and this leads to bone marrow failure. There are many reasons why this is significant." said Dr. Chun. "For example, when blood cells make wrong decisions the result can be a lack of a sufficient number of certain types of mature blood cells causing leukemia, anemia, or bone marrow failure."

Working with mice which had been genetically engineered to lack cullin 4A, the researchers found that within less than two weeks all blood cells disappeared because without this cullin, no new blood cells were being made.

"Our work is the first to show an effect in all blood cells and establishes that Cul4A is essential for the survival of blood cells and possibly other cells including cells of the intestine. It's still early in the scientific process but we know this protein is involved in many cellular pathways in the body. If we can learn about the pathway this protein takes, we may be able to develop targeted drug therapies that are better at attacking diseased blood cells and avoiding healthy ones," said Dr. Chun, who is a member of the IU Melvin and Bren Simon Cancer Center.


'/>"/>

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University
Source:Eurekalert  

Related biology news :

1. Cassini on the trail of a runaway mystery
2. For the paper trail of life on Mars or other planets, find cellulose
3. Aerodynamic trailer cuts fuel and emissions by up to 15 percent
4. St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia
5. Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
6. Researchers combat slowing yields with targeted fertilizer applications
7. Fishing throws targeted species off balance, Scripps study shows
8. New technique allows targeted inactivation of genes in research model
9. Newly identified role for power plants in human cells could lead to targeted therapies
10. Consortium develops new method enabling routine targeted gene modification
11. A new radiation therapy treatment developed for head and neck cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
On the trail of a targeted therapy for blood cancers
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
(Date:3/23/2016)... Massachusetts , March 23, 2016 /PRNewswire/ ... im Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung ... Xura, Inc. (NASDAQ: MESG ), ... bekannt, dass das Unternehmen mit SpeechPro zusammenarbeitet, ... aus der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, ...
(Date:3/21/2016)... 2016 Unique technology combines ... superior security   Xura, Inc. ... secure digital communications services, today announced it is working ... enterprise customers, particularly those in the Financial Services Sector, ... authentication within a mobile app, alongside, and in combination ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... , ... Supplyframe, the Industry Network for electronics hardware design ... Located in Pasadena, Calif., the Design Lab’s mission is to bring together inventors ... and brought to market. , The Design Lab is Supplyframe’s physical representation of ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published today ... a patient who developed lymphedema after being treated for breast cancer benefitted from an ... paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
(Date:6/23/2016)... , June 23, 2016 On Wednesday, ... at 4,833.32, down 0.22%; the Dow Jones Industrial Average edged ... closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on ... ), Nektar Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals ... (NASDAQ: BIND ). Learn more about these stocks ...
Breaking Biology Technology: