Navigation Links
On the trail of a targeted therapy for blood cancers
Date:10/10/2008

INDIANAPOLIS Investigators from the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine are focusing on a family of blood proteins that they hope holds a key to decreasing the toxic effects of chemotherapy in children and adults.

Their findings may one day help in the development of targeted therapies for leukemia, multiple myeloma and other cancers of the blood.

The researchers, led by Kristin T. Chun, Ph.D., assistant professor of pediatrics and of biochemistry and molecular biology, studied how the cullin family of proteins affects the degradation of proteins that control the development of blood cells. Their work was published in the July 15 issue of Blood, the journal of the American Society of Hematology.

The cullin family of proteins is involved in the degradation of proteins that control a myriad of cell functions, including those that determine whether a blood cell will eventually develop into a mature blood cell, will divide, or will undergo programmed cell death.

"How cullin 4A regulates other proteins that control the fate of blood cells is important because when cullin 4A fails to regulate their degradation properly, blood cells die and this leads to bone marrow failure. There are many reasons why this is significant." said Dr. Chun. "For example, when blood cells make wrong decisions the result can be a lack of a sufficient number of certain types of mature blood cells causing leukemia, anemia, or bone marrow failure."

Working with mice which had been genetically engineered to lack cullin 4A, the researchers found that within less than two weeks all blood cells disappeared because without this cullin, no new blood cells were being made.

"Our work is the first to show an effect in all blood cells and establishes that Cul4A is essential for the survival of blood cells and possibly other cells including cells of the intestine. It's still early
'/>"/>

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Cassini on the trail of a runaway mystery
2. For the paper trail of life on Mars or other planets, find cellulose
3. Aerodynamic trailer cuts fuel and emissions by up to 15 percent
4. St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia
5. Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
6. Researchers combat slowing yields with targeted fertilizer applications
7. Fishing throws targeted species off balance, Scripps study shows
8. New technique allows targeted inactivation of genes in research model
9. Newly identified role for power plants in human cells could lead to targeted therapies
10. Consortium develops new method enabling routine targeted gene modification
11. A new radiation therapy treatment developed for head and neck cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
On the trail of a targeted therapy for blood cancers
(Date:9/30/2014)... of environmental scientists and engineers, led by Clemson ... three-year, $5.25 million grant from the U.S. Department ... to make a direct positive impact on South ... disposal of radioactive contaminants. , "Understanding the scientific ... with environmental aspects of nuclear technologies is imperative ...
(Date:9/30/2014)... German . ... foods in the world. Because they grow underground, people use ... smell of truffles is not only of interest to gourmets. ... of the Goethe University Frankfurt have discovered that the smell ... are trapped inside truffle fruiting bodies. , White truffles from ...
(Date:9/30/2014)... doctor to know what goes wrong with your muscles because ... know what "normal" actually is. That,s where a new research ... FASEB Journal comes in. In the report, ... of molecules that can help scientists "see" which genes are ... they found never-before-detected gene activity and that men have approximately ...
Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2On the trail of the truffle flavor 2Scientists identify which genes are active in muscles of men and women 2
... in the December issue of Lancet Oncology challenges mainstream oncology ... as a major reason that cancer metastasizes or spreads to ... remarkable number of traits normally attributed to white blood cells ... nodes and distant organs and to form a new blood ...
... Current Biology, tsunami damage to coral reefs closest to ... spectacular, but surprisingly limited, particularly when compared to damage ... Less than 100 days after the tsunami of December ... University, the Wildlife Conservation Society-Indonesia Program, and Syiah Kuala ...
... University of Colorado at Boulder that can determine the ... within hours may help world health officials combat coming ... new technology by the Centers for Disease Control and ... determine the genetic make-up of types and subtypes of ...
Cached Biology News:New evidence supports century-old theory of cancer spread 2New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics 2New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics 3New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics 4
(Date:10/1/2014)... -- This report analyzes the worldwide markets ... the following Product Segments: Proteases, Polymerases, Carbohydrases, ... also analyzed are Pharmaceuticals & Diagnostics, Research/Biotechnology, ... separate comprehensive analytics for the US, Canada, ... America. Annual estimates and forecasts are provided ...
(Date:9/30/2014)... AMHERST, Mass. Using a bio-mimicking analog of ... of grass, an international research team led by ... has taken a major step in developing long-sought ... to electricity for use in electronic devices. ... UMass Amherst and others at Stanford University and ...
(Date:9/30/2014)... Over the last decade, the laboratory ... R&D budgets and increased acceptance of new filtration technologies ... biotechnology industries are also catalyzing the growth of laboratory ... expected to grow at a strong CAGR during the ... worth $2,532.6 million by 2019. The market is mainly ...
(Date:9/30/2014)... Hungary , September 30, 2014 ... and intuitive browsing of chemistry in documents ... chemistry software solutions and consulting services for life ... chemical information and generate Markush structures from documents. ... an organizations intellectual property, however generating and understanding ...
Breaking Biology Technology:Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2
... FluForecast® warning in April 7th, 2008, a year before ... company was able to state the likelihood of H1N1 ... which examines specific regions in virus genes which have ... below as published on the Web, stated that in ...
... 2009 and Host Call on Friday, May 1, 2009 EATONTOWN, ... ), a leader in the emerging field of biologic products ... ended March 31, 2009 financial results will be released Thursday, ... a conference call and webcast on Friday, May 1, 2009, ...
... CITY, China, April 24 Sinobiopharma, Inc. (OTC Bulletin ... highlights from the unaudited financial results for the nine month period ... , Sales revenue increased to ... US $1,170,677 in the corresponding period ended February 29, 2008. ...
Cached Biology Technology:Biotechnology Company Provided Advance Warning of Mexican H1N1 "Swine Flu" Virus Outbreak 2Biotechnology Company Provided Advance Warning of Mexican H1N1 "Swine Flu" Virus Outbreak 3Biotechnology Company Provided Advance Warning of Mexican H1N1 "Swine Flu" Virus Outbreak 4Osteotech Announces First Quarter 2009 Earnings Release and Conference Call 2Sinobiopharma Reports a 41% Increase in Revenues From Unaudited Financial Results for the 9 Month Period Ended February 28, 2009 2
Recombinant Rat Leptin, Ultra Pure...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: