Navigation Links
On the trail of a targeted therapy for blood cancers
Date:10/10/2008

INDIANAPOLIS Investigators from the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine are focusing on a family of blood proteins that they hope holds a key to decreasing the toxic effects of chemotherapy in children and adults.

Their findings may one day help in the development of targeted therapies for leukemia, multiple myeloma and other cancers of the blood.

The researchers, led by Kristin T. Chun, Ph.D., assistant professor of pediatrics and of biochemistry and molecular biology, studied how the cullin family of proteins affects the degradation of proteins that control the development of blood cells. Their work was published in the July 15 issue of Blood, the journal of the American Society of Hematology.

The cullin family of proteins is involved in the degradation of proteins that control a myriad of cell functions, including those that determine whether a blood cell will eventually develop into a mature blood cell, will divide, or will undergo programmed cell death.

"How cullin 4A regulates other proteins that control the fate of blood cells is important because when cullin 4A fails to regulate their degradation properly, blood cells die and this leads to bone marrow failure. There are many reasons why this is significant." said Dr. Chun. "For example, when blood cells make wrong decisions the result can be a lack of a sufficient number of certain types of mature blood cells causing leukemia, anemia, or bone marrow failure."

Working with mice which had been genetically engineered to lack cullin 4A, the researchers found that within less than two weeks all blood cells disappeared because without this cullin, no new blood cells were being made.

"Our work is the first to show an effect in all blood cells and establishes that Cul4A is essential for the survival of blood cells and possibly other cells including cells of the intestine. It's still early in the scientific process but we know this protein is involved in many cellular pathways in the body. If we can learn about the pathway this protein takes, we may be able to develop targeted drug therapies that are better at attacking diseased blood cells and avoiding healthy ones," said Dr. Chun, who is a member of the IU Melvin and Bren Simon Cancer Center.


'/>"/>

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University
Source:Eurekalert  

Related biology news :

1. Cassini on the trail of a runaway mystery
2. For the paper trail of life on Mars or other planets, find cellulose
3. Aerodynamic trailer cuts fuel and emissions by up to 15 percent
4. St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia
5. Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
6. Researchers combat slowing yields with targeted fertilizer applications
7. Fishing throws targeted species off balance, Scripps study shows
8. New technique allows targeted inactivation of genes in research model
9. Newly identified role for power plants in human cells could lead to targeted therapies
10. Consortium develops new method enabling routine targeted gene modification
11. A new radiation therapy treatment developed for head and neck cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
On the trail of a targeted therapy for blood cancers
(Date:3/14/2016)... http://www.apimages.com ) - ... - Renvoi : image disponible via AP Images ( ... --> DERMALOG, le leader de l,innovation ... d,empreintes digitales pour l,enregistrement des réfugiés en Allemagne. ... produire des cartes d,identité aux réfugiés. DERMALOG dévoilera ...
(Date:3/10/2016)... 2016 --> ... "Identity and Access Management Market by Component (Provisioning, Directory ... by Organization Size, by Deployment, by Vertical, and by ... The market is estimated to grow from USD 7.20 ... at a Compound Annual Growth Rate (CAGR) of 12.2% ...
(Date:3/9/2016)... , March 9, 2016 ... government identified that more than 23,000 public service employees ... had been receiving their salary unlawfully.    --> ... country,s government identified that more than 23,000 public service ... or had been receiving their salary unlawfully.    ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... ... 2016 , ... Last week, Callan Capital, an integrated wealth management firm specializing ... of San Diego Life Science event at the Estancia La Jolla Resort and Spa. ... with speakers Dr. Rich Heyman, former CEO of Aragon and Seragon, and Faheem Hasnain, ...
(Date:5/23/2016)... ... 23, 2016 , ... The need for blood donations in South Texas and across the nation ... Blood & Tissue Center, blood donations are on the decline. In fact, donations across the ... 21 percent in South Texas in the last four years alone. , There is no ...
(Date:5/23/2016)... , May 23, 2016 Zimmer Biomet Holdings, ... healthcare, today announced that its Board of Directors has approved ... the second quarter of 2016. The cash ... about July 29, 2016 to stockholders of record as of ... of dividends are subject to approval of the Board of ...
(Date:5/23/2016)... LONDON , May 23, 2016 ... Efficiency by 40% - Frontage Implement a Single Platform ... Quality, Compliance and Traceability Within the Bioanalytical lab Frontage ... the United States and China ... across its laboratory facilities. In addition to serving as the global ...
Breaking Biology Technology: