Navigation Links
Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model
Date:3/5/2013

PHILADELPHIA - Omega-3 fatty acids found in oily fish may have diverse health-promoting effects, potentially protecting the immune, nervous, and cardiovascular systems.

But how the health effects of one such fatty acid -- docosahexaenoic acid (DHA) -- works remains unclear, in part because its molecular signaling pathways are only now being understood.

Toshinori Hoshi, PhD, professor of Physiology, at the Perelman School of Medicine, University of Pennsylvania, and colleagues showed, in two papers out this week in the Proceedings of the National Academy of Sciences, how fish oils help lower blood pressure via vasodilation at ion channels. In vascular smooth muscle cells, such as those that line blood vessels, ion channels that span the outer membrane of a cell to let such ions as sodium, calcium, and potassium in and out, are critical to maintaining proper vessel pressure.

Omega-3 fatty acids bind directly to a specific group of channels that allow potassium ions to move out, which affects how much voltage is required to open the channel. If omega-3 fatty acids bind to the channel, only a small amount of voltage is needed. This is good for a cell because an open potassium channel means the cell is at rest, and when smooth blood muscle cells are relaxed, blood pressure is at a good level. However, when vessels constrict, blood pressure increases.

The researchers found that DHA rapidly and reversibly activates these channels by increasing currents by up to 20 fold. DHA lowers blood pressure in anesthetized wild type mice but not in mice genetically engineered without a specific ion channel subunit.

In comparison, the team found that a dietary supplement, DHA ethyl ester, found in most fish oil pills fails to activate the same channels, and even antagonizes the positive effect of DHA from natural sources, on the cells. The DHA ethyl ester seems to compete with the natural form of DHA for binding sites on the ion channel.

The team concluded that these channels have receptors for long-chain omega-3 fatty acids, and that DHA -- unlike its ethyl ester cousin -- activate the channels and lower blood pressure.

The findings have practical implications for the use of omega-3 fatty acids as nutraceuticals for the general public and also for critically ill patients who may receive omega-3enriched formulas as part of their nutrition.

Coauthor Michael Bauer from Jena University Hospital in Germany, who studies sepsis in a clinical setting, says the findings may encourage physicians to have a closer look at the specific formulations given to sepsis patients as they may contain either the free omega-3 acid or the ester.

The findings also underscore the importance of obtaining omega-3 fatty acids from natural food sources such as oily fish.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Related biology news :

1. Omega-3s inhibit breast cancer tumor growth, study finds
2. New and revised standards for omega-3s, natural sweeteners and other food ingredients proposed
3. Research, response for future oil spills: Lessons learned from Deepwater Horizon
4. NCEAS researchers offer new ecological model for deep-water oil spills
5. Nanopills release drugs directly from the inside of cells
6. Fat worms inch scientists toward better biofuel production
7. University of Alberta researchers bake a better loaf of bread
8. New device better traps viruses, airborne pathogens
9. New study indicates avocado consumption may be associated with better diet quality
10. Better outcome for frozen embryo replacement vs IVF
11. 2 antibodies are better than 1
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Florida (PRWEB) , ... October 11, 2017 , ... ... Drug Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 ... for the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane ...
(Date:10/10/2017)... -- International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... market and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase ... "The residential security market has experienced continued growth, ...
(Date:10/9/2017)... ... ... The award-winning American Farmer television series will feature 3 Bar Biologics in an ... on RFD-TV. , With global population estimates nearing ten billion people by 2050, ... a growing nation. At the same time, many of our valuable resources are becoming ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available ... bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, supplementing ...
Breaking Biology Technology: