Navigation Links
Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model

PHILADELPHIA - Omega-3 fatty acids found in oily fish may have diverse health-promoting effects, potentially protecting the immune, nervous, and cardiovascular systems.

But how the health effects of one such fatty acid -- docosahexaenoic acid (DHA) -- works remains unclear, in part because its molecular signaling pathways are only now being understood.

Toshinori Hoshi, PhD, professor of Physiology, at the Perelman School of Medicine, University of Pennsylvania, and colleagues showed, in two papers out this week in the Proceedings of the National Academy of Sciences, how fish oils help lower blood pressure via vasodilation at ion channels. In vascular smooth muscle cells, such as those that line blood vessels, ion channels that span the outer membrane of a cell to let such ions as sodium, calcium, and potassium in and out, are critical to maintaining proper vessel pressure.

Omega-3 fatty acids bind directly to a specific group of channels that allow potassium ions to move out, which affects how much voltage is required to open the channel. If omega-3 fatty acids bind to the channel, only a small amount of voltage is needed. This is good for a cell because an open potassium channel means the cell is at rest, and when smooth blood muscle cells are relaxed, blood pressure is at a good level. However, when vessels constrict, blood pressure increases.

The researchers found that DHA rapidly and reversibly activates these channels by increasing currents by up to 20 fold. DHA lowers blood pressure in anesthetized wild type mice but not in mice genetically engineered without a specific ion channel subunit.

In comparison, the team found that a dietary supplement, DHA ethyl ester, found in most fish oil pills fails to activate the same channels, and even antagonizes the positive effect of DHA from natural sources, on the cells. The DHA ethyl ester seems to compete with the natural form of DHA for binding sites on the ion channel.

The team concluded that these channels have receptors for long-chain omega-3 fatty acids, and that DHA -- unlike its ethyl ester cousin -- activate the channels and lower blood pressure.

The findings have practical implications for the use of omega-3 fatty acids as nutraceuticals for the general public and also for critically ill patients who may receive omega-3enriched formulas as part of their nutrition.

Coauthor Michael Bauer from Jena University Hospital in Germany, who studies sepsis in a clinical setting, says the findings may encourage physicians to have a closer look at the specific formulations given to sepsis patients as they may contain either the free omega-3 acid or the ester.

The findings also underscore the importance of obtaining omega-3 fatty acids from natural food sources such as oily fish.


Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Related biology news :

1. Omega-3s inhibit breast cancer tumor growth, study finds
2. New and revised standards for omega-3s, natural sweeteners and other food ingredients proposed
3. Research, response for future oil spills: Lessons learned from Deepwater Horizon
4. NCEAS researchers offer new ecological model for deep-water oil spills
5. Nanopills release drugs directly from the inside of cells
6. Fat worms inch scientists toward better biofuel production
7. University of Alberta researchers bake a better loaf of bread
8. New device better traps viruses, airborne pathogens
9. New study indicates avocado consumption may be associated with better diet quality
10. Better outcome for frozen embryo replacement vs IVF
11. 2 antibodies are better than 1
Post Your Comments:
Related Image:
Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model
(Date:10/29/2015)... ARBOR, Mich. , Oct. 29, 2015 /PRNewswire/ ... Eurofins Genomics for U.S. distribution of its DNA ... DNA-seq kit and Rubicon,s new ThruPLEX Plasma-seq kit. ... to enable the preparation of NGS libraries for ... plasma for diagnostic and prognostic applications in cancer ...
(Date:10/29/2015)... , Oct. 29, 2015 Today, ... announced a partnership with 2XU, a global leader ... deliver a smart hat with advanced bio-sensing technology. ... other athletes to monitor key biometrics to improve ... strategic partnership, the two companies will bring together the ...
(Date:10/27/2015)... Calif. , Oct. 27, 2015 Synaptics Inc. ... solutions, today announced that Google has adopted the Synaptics ... touch controller solutions to power its newest flagship smartphones, ... by Huawei. --> ... like Google to provide strategic collaboration in the joint ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... ... November 30, 2015 , ... ... physicians, aesthetic practitioners and aesthetics professionals from Central America and abroad for the ... in Panama City, Panama Feb. 17-19, 2016. Testart will present and discuss new ...
(Date:11/30/2015)... 1, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ), a ... the American Business Act on Climate Pledge, alongside more than ... with the Obama Administration to demonstrate an ongoing commitment to ... to the COP21 Paris climate negotiations. ... Sarnia, Canada . --> BioAmber uses ...
(Date:11/30/2015)... 30, 2015 Spherix Incorporated (Nasdaq: ... the fostering and monetization of intellectual property, today ... initiatives designed to create shareholder value. ... Spherix. "Based on published reports, the total addressable ... billion and Spherix will seek to secure fair ...
(Date:11/30/2015)...  HUYA Bioscience International, the leader in accelerating global ... today announced it has signed a Memorandum of Understanding ... collaboration between KDDF and HUYA with the ultimate goal ... for the global market. China,s ... innovative preclinical and clinical stage compounds. The company advances ...
Breaking Biology Technology: