Navigation Links
Olive oil component alleviates intestinal ischemia and reperfusion
Date:2/5/2013

Here's another reason why you should include olive oil in your diet: A new research report published in the Journal of Leukocyte Biology suggests that at least one compound in olive oil significantly reduces intestinal ischemia (restricted blood supply) and the resulting reperfusion injury (tissue damage caused when blood supply returns). The compound, called "oleuropein aglycone," is the most prominent polyphenol found in olive oil and could become a novel therapeutic target aimed at treating intestinal ischemia and reperfusion injury in humans. Ultimately, this research could lead to therapeutic benefits for patients with spinal cord injuries, arthritis and pleurisy, as well as those suffering from intestinal ischemia/reperfusion.

"The phenolic compounds of olive oil can reduce the secondary injury associated with intestinal damage," said Salvatore Cuzzocrea, Ph.D., a senior researcher involved in the work from the Department of Biology and Environmental Sciences at the University of Messina in Messina, Italy. "Oleuropein aglycone may be useful in the therapy of inflammation-associated disease."

To make this discovery, scientists used four groups of mice. The first group was subjected to intestinal ischemia by splanchnic arterial occlusion (SAO) followed by reperfusion. The second group was the same as the first but was also administered oleuropein aglycone. The third group of mice underwent identical surgical procedures except for SAO shock and was kept under anesthesia for the duration of the experiment. The last group was the same as the third, but was also given oleuropein aglycone. The histological structure of the gastrointestinal tract from the third group was typical of a normal architecture, but did not present any early inflammation. The ileum from animals subjected to intestinal ischemia/reperfusion injury (IRI) showed severe histological alteration with edema of the distal portion of the villi and the expression of pro-inflammatory cytokines, apoptosis and neutrophil infiltration were significantly increased. Oleuropein aglycone treated-mice showed reduced IRI-induced organ injury including a considerable reduction of inflammatory and apoptotic levels.

"Olive oil's healing properties have been known for millennia," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "but until relatively recently, we have had few direct scientific insights into exactly how it works in the body. Not only does this report shed light on the molecular details of how olive oil may provide health benefits, but it may open new doors to enhancing treatments based on this discovery."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. The millennium-old olive trees of the Iberian Peninsula are younger than expected
2. Selective grazing and aversion to olive and grape leaves achieved in goats and sheep
3. Intersil Expands Precision Analog IC Offerings with Micross Components
4. UGA study reveals flu-fighting role for well-known immune component
5. Micross Components Recognized as Teledyne Electronic Manufacturing Services Manufacturer of the Year
6. Reciprocity an important component of prosocial behavior
7. Manufacturing crack-resistant lightweight components
8. Production of FRP components without release agents
9. Researchers identify new components of the epigenetic code for honey bee development
10. Dolphin hearing system component found in insects
11. Johns Hopkins researchers uncover genes at fault for cystic fibrosis-related intestinal obstruction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)...  Singulex, Inc., the leader in Next Generation Immunodiagnostics ... license and supply agreement with Thermo Fisher Scientific, the ... access to Thermo Scientific BRAHMS PCT (Procalcitonin), a biomarker ... to diagnose systemic bacterial infection and sepsis and in ... in assessing the risk of critically ill patients for ...
(Date:12/7/2016)... December 7, 2016 BioCatch , the global ... its patent portfolio, which grew to over 40 granted and pending patents. ... , , ... patent entitled " System, Device, and Method Estimating Force Applied ... device makers to forego costly hardware components needed to estimate the force ...
(Date:12/7/2016)... Dec. 7, 2016   Veridium , a ... appointment of new CEO James Stickland . ... decades of experience, has served in senior executive ... he specialized in expanding a pipeline of venture ... He most recently served as managing director of ...
Breaking Biology News(10 mins):
(Date:1/13/2017)... 2017 Research and Markets has announced the ... Global Forecast to 2021" report to their offering. ... The biosimilars market is ... Billion in 2016, at a CAGR of 26.3%. ... manufacturing type, and application. Factors such as rising incidence of various ...
(Date:1/13/2017)... Staten Island, NY (PRWEB) , ... January 13, ... ... products to meet every cuvette-related demand that it has found among its diverse ... electroporation cuvettes for use in most brands electroporators including BTX and Bio-Rad. ...
(Date:1/12/2017)... North Carolina (PRWEB) , ... January 12, 2017 , ... ... called the Eureka Index – a process that evaluates the patent estate of a ... Immunolight LLC , a biomedical firm leading the way in technologies that transform ...
(Date:1/12/2017)... ... January 12, 2017 , ... After her brain ... doctors gave her only a few months to live. Now a paper publishing ... stabilized Rosendahl’s disease and increased both the quantity and quality of her life: ...
Breaking Biology Technology: