Navigation Links
Olive oil component alleviates intestinal ischemia and reperfusion
Date:2/5/2013

Here's another reason why you should include olive oil in your diet: A new research report published in the Journal of Leukocyte Biology suggests that at least one compound in olive oil significantly reduces intestinal ischemia (restricted blood supply) and the resulting reperfusion injury (tissue damage caused when blood supply returns). The compound, called "oleuropein aglycone," is the most prominent polyphenol found in olive oil and could become a novel therapeutic target aimed at treating intestinal ischemia and reperfusion injury in humans. Ultimately, this research could lead to therapeutic benefits for patients with spinal cord injuries, arthritis and pleurisy, as well as those suffering from intestinal ischemia/reperfusion.

"The phenolic compounds of olive oil can reduce the secondary injury associated with intestinal damage," said Salvatore Cuzzocrea, Ph.D., a senior researcher involved in the work from the Department of Biology and Environmental Sciences at the University of Messina in Messina, Italy. "Oleuropein aglycone may be useful in the therapy of inflammation-associated disease."

To make this discovery, scientists used four groups of mice. The first group was subjected to intestinal ischemia by splanchnic arterial occlusion (SAO) followed by reperfusion. The second group was the same as the first but was also administered oleuropein aglycone. The third group of mice underwent identical surgical procedures except for SAO shock and was kept under anesthesia for the duration of the experiment. The last group was the same as the third, but was also given oleuropein aglycone. The histological structure of the gastrointestinal tract from the third group was typical of a normal architecture, but did not present any early inflammation. The ileum from animals subjected to intestinal ischemia/reperfusion injury (IRI) showed severe histological alteration with edema of the distal portion of the villi and the expression of pro-inflammatory cytokines, apoptosis and neutrophil infiltration were significantly increased. Oleuropein aglycone treated-mice showed reduced IRI-induced organ injury including a considerable reduction of inflammatory and apoptotic levels.

"Olive oil's healing properties have been known for millennia," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "but until relatively recently, we have had few direct scientific insights into exactly how it works in the body. Not only does this report shed light on the molecular details of how olive oil may provide health benefits, but it may open new doors to enhancing treatments based on this discovery."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. The millennium-old olive trees of the Iberian Peninsula are younger than expected
2. Selective grazing and aversion to olive and grape leaves achieved in goats and sheep
3. Intersil Expands Precision Analog IC Offerings with Micross Components
4. UGA study reveals flu-fighting role for well-known immune component
5. Micross Components Recognized as Teledyne Electronic Manufacturing Services Manufacturer of the Year
6. Reciprocity an important component of prosocial behavior
7. Manufacturing crack-resistant lightweight components
8. Production of FRP components without release agents
9. Researchers identify new components of the epigenetic code for honey bee development
10. Dolphin hearing system component found in insects
11. Johns Hopkins researchers uncover genes at fault for cystic fibrosis-related intestinal obstruction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: