Navigation Links
Oliguridylation-mediated histone mRNA decay
Date:12/31/2007

In the January 1st issue of G&D, Drs. Thomas Mullen and William Marzluff (UNC Chapel Hill) lend new insight into the degradation of mammalian histone mRNA.

Histone mRNA is rapidly degraded at the end of S phase, but the mechanism by which this occurs has remained elusive, as metazoan histone mRNAs have a unique, conserved 3' stem-loop structure rather than the canonical 3' poly(A) tail.

Drs. Mullen & Marzluff demonstrate that uridine residues are added to the 3' end of histone mRNAs, after which the transcript is decapped and degraded at both ends by components of the general mRNA decay machinery.

This work represents the first example of the half-life of a specific mammalian mRNA transcript being regulated by oligouridylation.


'/>"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... (PRWEB) , ... August 11, 2017 , ... A staple ... campaign this month that will incorporate important key elements including a new digital marketing ... community that has supported them, Bill Miller has partnered with the South Texas Blood ...
(Date:8/10/2017)... Warsaw, Indiana (PRWEB) , ... August 09, 2017 ... ... is equipped to help the agriculture industry reach its ideal customers with the ... across the nation. , “As a Midwest company, we realize how crucial the ...
(Date:8/10/2017)... , ... August 09, 2017 , ... Each year in ... never recover well enough to live an independent lifestyle and, even worse, the one-year ... new discovery by doctors at the University of California Davis Medical Center (Sacramento) and ...
(Date:8/10/2017)... ... 10, 2017 , ... DrugDev and the Society for Clinical ... how Good Clinical Practice (GCP) can be used throughout the site activation process with ... the importance of GCP compliance, how sites are affected by GCP during selection and ...
Breaking Biology Technology: