Navigation Links
Oligonucleotide Delivery: Biology, Engineering and Development Conference
Date:6/27/2012

Oligonucleotide technologies, such as siRNA, tap into endogenous, highly conserved and specific catalytic mechanisms to efficiently regulate gene expression. As such, they have the potential to enable the development of novel therapeutic options for disease targets previously considered un-druggable by conventional small molecule and biologics means. However, despite the promise, clinical development has been hindered by the challenges encountered by identifying and developing safe and efficacious delivery formulations.

Since its discovery in 1998, RNA silencing has attracted much attention, with over 50,000 peer-reviewed publications, multiple national and international conferences, and significant investment in the biotech and large pharma with the goal of developing new siRNA-based therapies. Despite the interest and investment this has proven to be more difficult that first envisioned. It is widely recognized that there are gaps in our basic understanding on how to best harness this technology for therapeutic use.

The major topics to be discussed are:

Liposomes, nanosomes, polymeric and nano-particulate delivery vehicles
RNA chemical modifications and conjugates to enable delivery
Protein transduction domain as delivery platforms
Mechanisms of cellular uptake and endosomal escape
Biophysical characterization methods
siRNA delivery vehicle toxicology
Local and systemic siRNA delivery case studies

Confirmed Speakers
Achim Aigner, Philipps-University Marburg, Germany
Saghir Akhtar, Kuwait University, Kuwait
Eben Alsberg, Case Western Reserve University, USA
Dan Anderson, MIT, USA
Tomohiro Asai, University of Shizuoka, Japan
Himanshu Brahmbhatt, EnGeneIC Ltd, Australia
Bob Brown, Dicerna, USA
Kenneth Clark, GlaxoSmithKline, UK
Pieter Cullis, University of British Columbia, Canada
Mark E. Davis, California Institute of Technology, USA
'/>"/>

Contact: Kevin Korpics
kevin@engconfintl.org
Engineering Conferences International
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Melting glaciers, enough sand to bury London, and ancient ecosystem engineering
3. Innovative cell printing technologies hold promise for tissue engineering R&D
4. 5th Annual Advances in Biomolecular Engineering Symposium
5. Medical device, health professionals attend first national conference on value-driven engineering
6. NSF report detailing growth in graduate enrollment in science & engineering in the past decade
7. Investigation of American Oriental Bioengineering, Inc. by Securities Lawyers at Goldfarb LLP Law Firm for Potential Shareholder Claim
8. Artificial womb unlocks secrets of early embryo development
9. REST is crucial for the timing of brain development
10. Embryonic development protein active in cancer growth
11. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD and ... on the growing mobile commerce market, announces it has retained ... for the 2015 International CES debut of the Wocket™ biometric ... be at the NXT-ID booth January 6th and 7 th ...
(Date:12/19/2014)... , Dec. 18, 2014  23andMe, Inc., the leading personal genetics ... fine-scale differences in genetic ancestry of individuals from across ... first arrived more than four hundred years ago, ... place for peoples from different continents. This study illuminates how ...
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance biometric ... to industry leaders such as Intel, Jabra, Atlas, and ... wearable products. These products will be showcased at CES ... Vegas . "Our partners choose ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 423andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... For 25 years, researchers have tried and failed to develop ... of engineered "super antibodies" to fend off the virus ... have proved impossible to produce in people. Now, in research ... scientists at The Rockefeller University have laid out a new ...
... of iron homeostasis is a common feature of prion ... new study by Dr. Neena Singh and colleagues at ... from Creighton University. These findings, published March 13 in ... insight into the mechanism of neurotoxicity in prion disorders, ...
... at Kansas State,University, with collaboration from Epitopix LLC, ... E. coli O157 in beef cattle. ... on the post-harvest food safety,aspect, whether it,s ... of,K-State,s College of Veterinary Medicine. Thomson is the ...
Cached Biology News:A natural approach for HIV vaccine 2A natural approach for HIV vaccine 3Iron is involved in prion disease-associated neuronal demise 2K-State researchers help Epitopix license the United States' first E. coli O157 vaccine for cattle 2
(Date:1/22/2015)... 22, 2015  Transwestern | RBJ today announces the firm brokered ... for Shire a leading biopharmaceutical company, at Two Ledgemont Center ... Robert Richards , president, and Brian Cohen , ... entire five-floor building at 95 Hayden Ave. Photo ...
(Date:1/22/2015)... Diego, California (PRWEB) January 22, 2015 ... Promotional Offer to their comprehensive portfolio of Eppendorf ... allows customers to purchase a Centrifuge 5424/5424 R and ... Bundle of either Eppendorf Research plus or Eppendorf Reference ...
(Date:1/22/2015)... NJ (PRWEB) January 22, 2015 ... technologies such as the Bioruptor® and complete solutions ... system for chromatin immunoprecipitation, alleviating the need for ... and controls needed for ChIP of histones or ...
(Date:1/22/2015)... N.J. , Jan. 22, 2015  Derma Sciences, ... regeneration company focused on advanced wound care, announces ... placental tissues, have been added to the Premier, ... increases the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... -- Bruker AXS Inc. on Thursday announced the promotions ... to executive vice presidents, responsible for leading all aspects ... the Madison headquarters of Bruker AXS, now leads the ... as chief technology officer heads global R&D. , ,Burgaezy, ...
... describes today's go-it-alone economic climate than the word "entrepreneur." ... appealing to those who would strike out on their ... large and small along with colleges and universities and ... to help them in their quests to be successful ...
... CHICAGO -Last week, we talked about the size and ... key market segments. This week's column will focus on the ... , ,Before we comment on some trends from this ... absent here is the major part of the diagnostics business ...
Cached Biology Technology:Beware -- Use of the word 'entrepreneur' can put you in a legal mess 2Beware -- Use of the word 'entrepreneur' can put you in a legal mess 3Beware -- Use of the word 'entrepreneur' can put you in a legal mess 4Beware -- Use of the word 'entrepreneur' can put you in a legal mess 5Midwest plays key role in developing new medical device companies 2Midwest plays key role in developing new medical device companies 3
Activating Agents, 7-azabenzotriazol-1-yloxy-tris-(pyrrolidino)phosphonium hexafluorophosphate...
... Clone/PAD: ZMD.283. Immunogen: Fusion ... Specificity: Specific for ASIP/PAR-3 (atypical PKC ... This antigen is not related to ... Reactivity: Human Dog Xenopus (positive controls: ...
...
Request Info...
Biology Products: