Navigation Links
Older siblings' cells can be passed from female dogs to their puppies in the womb, MU researchers find
Date:10/23/2013

COLUMBIA, Mo. Some people possess a small number of cells in their bodies that are not genetically their own; this condition is known as microchimerism. In prior studies, researchers from the University of Missouri College of Veterinary Medicine found that this condition also exists in dogs. Now, the researchers have found evidence that this condition can be passed from a female dog to her offspring while they are still in the womb. Jeffrey Bryan, an associate professor of oncology at the MU College of Veterinary Medicine and director of Comparative Oncology and Epigenetics Laboratory, says this discovery will help further study into the health effects of microchimerism in dogs and in humans.

"We already have some evidence that microchimerism may increase risk of thyroid disease while lowering the risk of breast cancer in women," Bryan said. "The pet dog represents an excellent model of many ailments in people, and the presence of fetal microchimerism in dogs will allow studies which further clarify its role in health and disease. Knowing that the condition can be passed on through birth will help us track the condition and its effects through several generations of animals."

Microchimerism most often occurs when a mother gives birth to a child. In some cases, cells from that child are left in the mothers' body and continue to live, despite being of a different genetic makeup than surrounding cells. The MU researchers have identified evidence that those cells can then be passed on to other children the mother may give birth to at a later time.

In their study, Senthil Kumar, a co-investigator in this study and assistant research professor and assistant director of the Comparative Oncology and Epigenetics Laboratory and Bryan, along with MU researchers Sandra Axiak-Bechtel, assistant professor of oncology, and Sara Hansen, a comparative medicine resident at MU,found microchimerism in a female dog that had given birth to male and female puppies. The researchers found cells with Y-chromosomes in the mother after these births, meaning the mother had male cells present in her female body. The researchers also found genetically similar male cells in the mother's female puppies from a later litter. Those puppies were newborn and had never been pregnant, strongly suggesting that they acquired the cells that were left behind by their older brothers while in the womb.

"These new findings are significant because they suggest that the movement, or trafficking, of fetal cells is quite extensive in dogs, as has been suggested in people," Bryan said. "This degree of cell trafficking can have an impact on health, disease, and therapy, including in transplantation. The identification of this phenomenon strongly suggests that companion dogs will help us more rapidly understand the real impact of microchimerism in human medicine."

Kumar, Hansen, Axiak-Bechtel, and Bryan plan on continuing their research to follow the lifespans of dogs with microchimerism to determine to what diseases those dogs may be susceptible.


'/>"/>

Contact: Nathan Hurst
hurstn@missouri.edu
573-882-6217
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. Saliva proteins may protect older people from influenza
2. Older US-born Mexican-Americans more physically limited than Mexican-American immigrants: Study
3. Eating fish associated with lower risk of dying among older adults
4. Acquisition of BioClinica, Inc. by JLL Partners, Inc. May Not Be in BioClinica, Inc. Shareholders Best Interests
5. Protein origami: Quick folders are the best
6. New study highlights impact of environmental change on older people
7. Intensive training for aphasia: Even older patients can improve
8. Medbox Communicates with Shareholders, Comments on Pending Transition to OTC Bulletin Board, and Announces Appearance on Fox Business News Channel
9. Older adults who are frail much more likely to be food insufficient, according to national study
10. Older overweight children consume fewer calories than their healthy weight peers
11. Nutrition tied to improved sperm DNA quality in older men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
(Date:5/16/2016)... NEW YORK , May 16, 2016   ... authentication solutions, today announced the opening of an IoT ... to strengthen and expand the development of embedded ... provides an unprecedented level of convenience and security with ... to authenticate one,s identity aside from DNA. EyeLock,s platform ...
(Date:5/3/2016)... May 3, 2016  Neurotechnology, a provider of ... MegaMatcher Automated Biometric Identification System (ABIS) , a ... projects. MegaMatcher ABIS can process multiple complex biometric ... combination of fingerprint, face or iris biometrics. It ... and MegaMatcher Accelerator , which have ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... regulatory and technical consulting, provides a free webinar on Performing Quality ... 13, 2016 at 12pm CT at no charge. , Incomplete investigations are still ...
(Date:6/22/2016)... June 22, 2016 Cell Applications, Inc. ... them to produce up to one billion human ... within one week. These high-quality, consistent stem cells ... cells and spend more time doing meaningful, relevant ... proprietary, high-volume manufacturing process that produces affordable, reliable ...
(Date:6/22/2016)... Philadelphia, PA (PRWEB) , ... June 22, 2016 ... ... the University City Science Center’s Port business incubator and current participant in the ... therapy and treatment for cancer patients. , Quantitative Radiology Solutions helps physicians ...
Breaking Biology Technology: