Navigation Links
Older siblings' cells can be passed from female dogs to their puppies in the womb, MU researchers find
Date:10/23/2013

COLUMBIA, Mo. Some people possess a small number of cells in their bodies that are not genetically their own; this condition is known as microchimerism. In prior studies, researchers from the University of Missouri College of Veterinary Medicine found that this condition also exists in dogs. Now, the researchers have found evidence that this condition can be passed from a female dog to her offspring while they are still in the womb. Jeffrey Bryan, an associate professor of oncology at the MU College of Veterinary Medicine and director of Comparative Oncology and Epigenetics Laboratory, says this discovery will help further study into the health effects of microchimerism in dogs and in humans.

"We already have some evidence that microchimerism may increase risk of thyroid disease while lowering the risk of breast cancer in women," Bryan said. "The pet dog represents an excellent model of many ailments in people, and the presence of fetal microchimerism in dogs will allow studies which further clarify its role in health and disease. Knowing that the condition can be passed on through birth will help us track the condition and its effects through several generations of animals."

Microchimerism most often occurs when a mother gives birth to a child. In some cases, cells from that child are left in the mothers' body and continue to live, despite being of a different genetic makeup than surrounding cells. The MU researchers have identified evidence that those cells can then be passed on to other children the mother may give birth to at a later time.

In their study, Senthil Kumar, a co-investigator in this study and assistant research professor and assistant director of the Comparative Oncology and Epigenetics Laboratory and Bryan, along with MU researchers Sandra Axiak-Bechtel, assistant professor of oncology, and Sara Hansen, a comparative medicine resident at MU,found microchimerism in a female dog that had given birth to male and female puppies. The researchers found cells with Y-chromosomes in the mother after these births, meaning the mother had male cells present in her female body. The researchers also found genetically similar male cells in the mother's female puppies from a later litter. Those puppies were newborn and had never been pregnant, strongly suggesting that they acquired the cells that were left behind by their older brothers while in the womb.

"These new findings are significant because they suggest that the movement, or trafficking, of fetal cells is quite extensive in dogs, as has been suggested in people," Bryan said. "This degree of cell trafficking can have an impact on health, disease, and therapy, including in transplantation. The identification of this phenomenon strongly suggests that companion dogs will help us more rapidly understand the real impact of microchimerism in human medicine."

Kumar, Hansen, Axiak-Bechtel, and Bryan plan on continuing their research to follow the lifespans of dogs with microchimerism to determine to what diseases those dogs may be susceptible.


'/>"/>

Contact: Nathan Hurst
hurstn@missouri.edu
573-882-6217
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. Saliva proteins may protect older people from influenza
2. Older US-born Mexican-Americans more physically limited than Mexican-American immigrants: Study
3. Eating fish associated with lower risk of dying among older adults
4. Acquisition of BioClinica, Inc. by JLL Partners, Inc. May Not Be in BioClinica, Inc. Shareholders Best Interests
5. Protein origami: Quick folders are the best
6. New study highlights impact of environmental change on older people
7. Intensive training for aphasia: Even older patients can improve
8. Medbox Communicates with Shareholders, Comments on Pending Transition to OTC Bulletin Board, and Announces Appearance on Fox Business News Channel
9. Older adults who are frail much more likely to be food insufficient, according to national study
10. Older overweight children consume fewer calories than their healthy weight peers
11. Nutrition tied to improved sperm DNA quality in older men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2016)... 1, 2016 Favorable Government Initiatives ... and Criminal Identification to Boost Global Biometrics System Market ... TechSci Research report, " Global Biometrics Market By ... and Opportunities, 2011 - 2021", the global biometrics market ... on account of growing security concerns across various end ...
(Date:5/20/2016)... 20, 2016  VoiceIt is excited to announce ... By working together, VoiceIt and VoicePass ... and VoicePass take slightly different approaches to voice ... security and usability. ... new partnership. "This marketing and technology ...
(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... ... 2016 , ... STACS DNA Inc., the sample tracking software company, today announced ... has joined STACS DNA as a Field Application Specialist. , “I am thrilled ... COO of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays ...
(Date:6/23/2016)... NEWPORT BEACH, Calif. , June 23, 2016 /PRNewswire/ ... offering new biological discoveries to the medical community, has ... and co-founder Matthew Nunez . "We ... provide us with the capital we need to meet ... funding will essentially provide us the runway to complete ...
Breaking Biology Technology: